PKN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0043297Biological processapical junction assembly
GO_0010631Biological processepithelial cell migration
GO_0007165Biological processsignal transduction
GO_0051301Biological processcell division
GO_0007155Biological processcell adhesion
GO_0030030Biological processcell projection organization
GO_0045070Biological processpositive regulation of viral genome replication
GO_0045931Biological processpositive regulation of mitotic cell cycle
GO_0035556Biological processintracellular signal transduction
GO_2000145Biological processregulation of cell motility
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0032467Biological processpositive regulation of cytokinesis
GO_0030496Cellular componentmidbody
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0043296Cellular componentapical junction complex
GO_0016604Cellular componentnuclear body
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0032154Cellular componentcleavage furrow
GO_0030027Cellular componentlamellipodium
GO_0005634Cellular componentnucleus
GO_0070063Molecular functionRNA polymerase binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0045296Molecular functioncadherin binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031267Molecular functionsmall GTPase binding
GO_0004672Molecular functionprotein kinase activity
GO_0005524Molecular functionATP binding
GO_0016301Molecular functionkinase activity
GO_0003723Molecular functionRNA binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene namePKN2
Protein nameProtein kinase N2
PKN2 protein
Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2)
SynonymsPRK2
PRKCL2
hCG_23733
DescriptionFUNCTION: PKC-related serine/threonine-protein kinase and Rho/Rac effector protein that participates in specific signal transduction responses in the cell. Plays a role in the regulation of cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumor cell invasion and transcription activation signaling processes. Phosphorylates CTTN in hyaluronan-induced astrocytes and hence decreases CTTN ability to associate with filamentous actin. Phosphorylates HDAC5, therefore lead to impair HDAC5 import. Direct RhoA target required for the regulation of the maturation of primordial junctions into apical junction formation in bronchial epithelial cells. Required for G2/M phases of the cell cycle progression and abscission during cytokinesis in a ECT2-dependent manner. Stimulates FYN kinase activity that is required for establishment of skin cell-cell adhesion during keratinocytes differentiation. Regulates epithelial bladder cells speed and direction of movement during cell migration and tumor cell invasion. Inhibits Akt pro-survival-induced kinase activity. Mediates Rho protein-induced transcriptional activation via the c-fos serum response factor (SRF). Involved in the negative regulation of ciliogenesis . .; FUNCTION: (Microbial infection) Phosphorylates HCV NS5B leading to stimulation of HCV RNA replication. .

AccessionsENST00000370513.9 [Q16513-3]
H0Y5V5
Q8N2Y1
Q16513
ENST00000436111.1
ENST00000370521.8 [Q16513-1]
H0Y429
B1AL79
ENST00000449189.1
Q6P5W9
ENST00000316005.11