BUB1B | OmnibusX

Name	Number of supported studies	Average coverage
transit amplifying cell	3 studies	29% ± 7%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of BUB1B at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
skin	97%	1178.23	1753 / 1809	93%	15.62	440 / 472
lung	76%	200.99	437 / 578	88%	15.17	1021 / 1155
intestine	55%	297.59	530 / 966	96%	17.59	508 / 527
stomach	48%	178.62	172 / 359	98%	17.57	279 / 286
esophagus	44%	339.51	643 / 1445	100%	25.23	183 / 183
breast	43%	68.92	198 / 459	91%	13.82	1022 / 1118
bladder	24%	34.33	5 / 21	92%	14.99	463 / 504
ovary	16%	38.33	29 / 180	97%	13.48	417 / 430
uterus	15%	27.24	25 / 170	97%	21.53	446 / 459
ureter	0%	0	0 / 0	100%	4.50	1 / 1
tonsil	0%	0	0 / 0	98%	24.46	44 / 45
spleen	98%	582.62	235 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	22.14	27 / 29
pancreas	13%	16.62	41 / 328	73%	5.67	130 / 178
adrenal gland	53%	87.33	136 / 258	17%	1.29	39 / 230
prostate	37%	49.53	91 / 245	26%	1.48	130 / 502
brain	10%	10.36	265 / 2642	48%	5.71	340 / 705
thymus	32%	44.08	208 / 653	26%	3.96	157 / 605
liver	16%	41.31	36 / 226	40%	3.15	164 / 406
peripheral blood	50%	1592.10	462 / 929	0%	0	0 / 0
kidney	27%	56.03	24 / 89	18%	1.16	164 / 901
adipose	34%	62.03	405 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	20%	0.88	16 / 80
blood vessel	15%	21.05	199 / 1335	0%	0	0 / 0
heart	14%	20.59	122 / 861	0%	0	0 / 0
muscle	2%	1.55	13 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0071459	Biological process	protein localization to chromosome, centromeric region
GO_0007091	Biological process	metaphase/anaphase transition of mitotic cell cycle
GO_0051301	Biological process	cell division
GO_0051754	Biological process	meiotic sister chromatid cohesion, centromeric
GO_0006915	Biological process	apoptotic process
GO_0007094	Biological process	mitotic spindle assembly checkpoint signaling
GO_0005680	Cellular component	anaphase-promoting complex
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0005813	Cellular component	centrosome
GO_0000776	Cellular component	kinetochore
GO_0033597	Cellular component	mitotic checkpoint complex
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0000940	Cellular component	outer kinetochore
GO_0005819	Cellular component	spindle
GO_0005634	Cellular component	nucleus
GO_0106310	Molecular function	protein serine kinase activity
GO_0004674	Molecular function	protein serine/threonine kinase activity
GO_0004672	Molecular function	protein kinase activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding

Gene name	BUB1B
Protein name	BUB1B BUB1 mitotic checkpoint serine/threonine kinase B Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (EC 2.7.11.1) (MAD3/BUB1-related protein kinase) (hBUBR1) (Mitotic checkpoint kinase MAD3L) (Protein SSK1)
Synonyms	MAD3L BUBR1 SSK1
Description	FUNCTION: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. .
Accessions	D6PW95 H0YN44 ENST00000558715.5 ENST00000412359.7 [O60566-3] O60566 ENST00000287598.11 [O60566-1] ENST00000559733.5 H0YMK5

BUB1B report