ING4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902749Biological processregulation of cell cycle G2/M phase transition
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001558Biological processregulation of cell growth
GO_0006338Biological processchromatin remodeling
GO_1902164Biological processpositive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0140889Biological processDNA replication-dependent chromatin disassembly
GO_0006355Biological processregulation of DNA-templated transcription
GO_2000278Biological processregulation of DNA biosynthetic process
GO_0006915Biological processapoptotic process
GO_0006473Biological processprotein acetylation
GO_0045926Biological processnegative regulation of growth
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0051726Biological processregulation of cell cycle
GO_0005654Cellular componentnucleoplasm
GO_0045111Cellular componentintermediate filament cytoskeleton
GO_0005829Cellular componentcytosol
GO_0000123Cellular componenthistone acetyltransferase complex
GO_0005634Cellular componentnucleus
GO_0035064Molecular functionmethylated histone binding
GO_0043997Molecular functionhistone H4K12 acetyltransferase activity
GO_0036408Molecular functionhistone H3K14 acetyltransferase activity
GO_0046972Molecular functionhistone H4K16 acetyltransferase activity
GO_0043996Molecular functionhistone H4K8 acetyltransferase activity
GO_0043995Molecular functionhistone H4K5 acetyltransferase activity
GO_0046872Molecular functionmetal ion binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameING4
Protein nameInhibitor of growth family member 4 variant deltaEx6B (cDNA FLJ53613, highly similar to Inhibitor of growth protein 4)
Inhibitor of growth family member 4
Inhibitor of growth protein 4 (p29ING4)
SynonymsMy036
DescriptionFUNCTION: Component of HBO1 complexes, which specifically mediate acetylation of histone H3 at 'Lys-14' (H3K14ac), and have reduced activity toward histone H4 . Through chromatin acetylation it may function in DNA replication . May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation . Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA . May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC . Represses hypoxia inducible factor's (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1) . Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity). .

AccessionsENST00000467678.5
R4GNG1
ENST00000482489.5
ENST00000444704.5 [Q9UNL4-3]
E9PJ14
E9PNE3
ENST00000493873.1
ENST00000619641.4
ENST00000341550.9 [Q9UNL4-2]
ENST00000488381.5
ENST00000446105.6 [Q9UNL4-4]
Q9UNL4
ENST00000423703.6 [Q9UNL4-8]
A4KYM5
ENST00000469749.5
ENST00000412586.6 [Q9UNL4-5]
A4KYM7
H0YEH7
ENST00000479301.5
ENST00000396807.8 [Q9UNL4-1]