Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| enterocyte | 7 studies | 44% ± 15% | |
| goblet cell | 6 studies | 27% ± 8% | |
| epithelial cell | 5 studies | 39% ± 8% | |
| enteroendocrine cell | 4 studies | 23% ± 7% | |
| progenitor cell | 4 studies | 30% ± 6% | |
| brush cell | 4 studies | 23% ± 4% | |
| intestinal crypt stem cell | 3 studies | 27% ± 8% | |
| transit amplifying cell | 3 studies | 20% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| intestine | 3 studies | 23% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 86% | 7873.05 | 827 / 966 | 93% | 144.06 | 492 / 527 |
| stomach | 79% | 146.11 | 283 / 359 | 93% | 131.43 | 265 / 286 |
| pancreas | 100% | 1272.37 | 328 / 328 | 66% | 30.05 | 118 / 178 |
| liver | 100% | 1031.02 | 226 / 226 | 59% | 30.04 | 241 / 406 |
| kidney | 100% | 990.80 | 89 / 89 | 28% | 8.21 | 254 / 901 |
| peripheral blood | 76% | 47.80 | 707 / 929 | 0% | 0 | 0 / 0 |
| lung | 48% | 13.35 | 275 / 578 | 24% | 14.89 | 274 / 1155 |
| spleen | 67% | 17.74 | 161 / 241 | 0% | 0 | 0 / 0 |
| esophagus | 7% | 5.90 | 102 / 1445 | 46% | 42.79 | 84 / 183 |
| skin | 42% | 14.40 | 754 / 1809 | 0% | 0 | 0 / 472 |
| bladder | 10% | 5.33 | 2 / 21 | 26% | 40.10 | 132 / 504 |
| uterus | 11% | 3.48 | 18 / 170 | 7% | 4.78 | 34 / 459 |
| prostate | 13% | 3.60 | 33 / 245 | 1% | 0.08 | 3 / 502 |
| ovary | 11% | 2.09 | 20 / 180 | 2% | 0.83 | 9 / 430 |
| breast | 10% | 28.37 | 48 / 459 | 0% | 0.23 | 5 / 1118 |
| adipose | 7% | 2.20 | 89 / 1204 | 0% | 0 | 0 / 0 |
| muscle | 7% | 1.54 | 59 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 5% | 1.29 | 73 / 1335 | 0% | 0 | 0 / 0 |
| heart | 5% | 1.00 | 45 / 861 | 0% | 0 | 0 / 0 |
| brain | 5% | 1.00 | 135 / 2642 | 0% | 0 | 0 / 705 |
| thymus | 3% | 0.44 | 17 / 653 | 0% | 0.02 | 1 / 605 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.52 | 1 / 45 |
| adrenal gland | 1% | 0.40 | 3 / 258 | 0% | 0.06 | 1 / 230 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032532 | Biological process | regulation of microvillus length |
| GO_0051016 | Biological process | barbed-end actin filament capping |
| GO_2000394 | Biological process | positive regulation of lamellipodium morphogenesis |
| GO_0030855 | Biological process | epithelial cell differentiation |
| GO_0071364 | Biological process | cellular response to epidermal growth factor stimulus |
| GO_0030042 | Biological process | actin filament depolymerization |
| GO_0051125 | Biological process | regulation of actin nucleation |
| GO_0009617 | Biological process | response to bacterium |
| GO_0035729 | Biological process | cellular response to hepatocyte growth factor stimulus |
| GO_0032233 | Biological process | positive regulation of actin filament bundle assembly |
| GO_0030041 | Biological process | actin filament polymerization |
| GO_0051693 | Biological process | actin filament capping |
| GO_0060327 | Biological process | cytoplasmic actin-based contraction involved in cell motility |
| GO_0008154 | Biological process | actin polymerization or depolymerization |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0051014 | Biological process | actin filament severing |
| GO_1903078 | Biological process | positive regulation of protein localization to plasma membrane |
| GO_1902896 | Biological process | terminal web assembly |
| GO_0030335 | Biological process | positive regulation of cell migration |
| GO_0001951 | Biological process | intestinal D-glucose absorption |
| GO_0061041 | Biological process | regulation of wound healing |
| GO_0006915 | Biological process | apoptotic process |
| GO_0007173 | Biological process | epidermal growth factor receptor signaling pathway |
| GO_0008360 | Biological process | regulation of cell shape |
| GO_0030836 | Biological process | positive regulation of actin filament depolymerization |
| GO_2000392 | Biological process | regulation of lamellipodium morphogenesis |
| GO_0040018 | Biological process | positive regulation of multicellular organism growth |
| GO_0010634 | Biological process | positive regulation of epithelial cell migration |
| GO_0001726 | Cellular component | ruffle |
| GO_0005903 | Cellular component | brush border |
| GO_0005902 | Cellular component | microvillus |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0032433 | Cellular component | filopodium tip |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0030175 | Cellular component | filopodium |
| GO_0015629 | Cellular component | actin cytoskeleton |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030027 | Cellular component | lamellipodium |
| GO_0032432 | Cellular component | actin filament bundle |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0043027 | Molecular function | cysteine-type endopeptidase inhibitor activity involved in apoptotic process |
| GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0035727 | Molecular function | lysophosphatidic acid binding |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | VIL1 |
| Protein name | Villin 1 Villin-1 |
| Synonyms | VIL |
| Description | FUNCTION: Epithelial cell-specific Ca(2+)-regulated actin-modifying protein that modulates the reorganization of microvillar actin filaments. Plays a role in the actin nucleation, actin filament bundle assembly, actin filament capping and severing. Binds phosphatidylinositol 4,5-bisphosphate (PIP2) and lysophosphatidic acid (LPA); binds LPA with higher affinity than PIP2. Binding to LPA increases its phosphorylation by SRC and inhibits all actin-modifying activities. Binding to PIP2 inhibits actin-capping and -severing activities but enhances actin-bundling activity. Regulates the intestinal epithelial cell morphology, cell invasion, cell migration and apoptosis. Protects against apoptosis induced by dextran sodium sulfate (DSS) in the gastrointestinal epithelium. Appears to regulate cell death by maintaining mitochondrial integrity. Enhances hepatocyte growth factor (HGF)-induced epithelial cell motility, chemotaxis and wound repair. Upon S.flexneri cell infection, its actin-severing activity enhances actin-based motility of the bacteria and plays a role during the dissemination. . |
| Accessions | C9J2B5 ENST00000248444.10 [P09327-1] ENST00000440053.1 [P09327-2] ENST00000454069.5 P09327 ENST00000392114.6 ENST00000419986.1 B4DV78 H7C0B6 |
