HIP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0097190Biological processapoptotic signaling pathway
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0006897Biological processendocytosis
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0045742Biological processpositive regulation of epidermal growth factor receptor signaling pathway
GO_0048268Biological processclathrin coat assembly
GO_0042981Biological processregulation of apoptotic process
GO_0030154Biological processcell differentiation
GO_0050821Biological processprotein stabilization
GO_0099171Biological processpresynaptic modulation of chemical synaptic transmission
GO_0007015Biological processactin filament organization
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0030100Biological processregulation of endocytosis
GO_0006915Biological processapoptotic process
GO_0051897Biological processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO_0099637Biological processneurotransmitter receptor transport
GO_2000588Biological processpositive regulation of platelet-derived growth factor receptor-beta signaling pathway
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0005856Cellular componentcytoskeleton
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0016020Cellular componentmembrane
GO_0030136Cellular componentclathrin-coated vesicle
GO_0005794Cellular componentGolgi apparatus
GO_0030864Cellular componentcortical actin cytoskeleton
GO_0098794Cellular componentpostsynapse
GO_0042734Cellular componentpresynaptic membrane
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0045211Cellular componentpostsynaptic membrane
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0035612Molecular functionAP-2 adaptor complex binding
GO_0032051Molecular functionclathrin light chain binding
GO_0005154Molecular functionepidermal growth factor receptor binding
GO_0005200Molecular functionstructural constituent of cytoskeleton
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0051015Molecular functionactin filament binding
GO_0035091Molecular functionphosphatidylinositol binding
GO_0032266Molecular functionphosphatidylinositol-3-phosphate binding
GO_0035615Molecular functionclathrin adaptor activity
GO_0030276Molecular functionclathrin binding
GO_0035254Molecular functionglutamate receptor binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0080025Molecular functionphosphatidylinositol-3,5-bisphosphate binding
GO_0005515Molecular functionprotein binding
GO_0043325Molecular functionphosphatidylinositol-3,4-bisphosphate binding

IV. Literature review

[source]
Gene nameHIP1
Protein nameHuntingtin interacting protein 1
HIP1 protein
Huntingtin-interacting protein 1
Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I)
Synonyms
DescriptionFUNCTION: Plays a role in clathrin-mediated endocytosis and trafficking . Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription . May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway . Binds 3-phosphoinositides (via ENTH domain) . May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis . May play a functional role in the cell filament networks . May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors . .

AccessionsENST00000434438.6 [O00291-3]
ENST00000336926.11 [O00291-1]
Q8TDA4
C9JMG5
ENST00000616821.4 [O00291-4]
O00291
A4VCI6
ENST00000420909.1