Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 34 studies | 32% ± 13% | |
| pericyte | 26 studies | 32% ± 16% | |
| smooth muscle cell | 16 studies | 34% ± 15% | |
| oligodendrocyte | 14 studies | 59% ± 17% | |
| oligodendrocyte precursor cell | 14 studies | 59% ± 17% | |
| fibroblast | 14 studies | 29% ± 12% | |
| astrocyte | 11 studies | 30% ± 11% | |
| macrophage | 11 studies | 27% ± 9% | |
| type I pneumocyte | 9 studies | 40% ± 18% | |
| capillary endothelial cell | 9 studies | 24% ± 11% | |
| endothelial cell of lymphatic vessel | 9 studies | 38% ± 13% | |
| adipocyte | 8 studies | 31% ± 7% | |
| dendritic cell | 8 studies | 36% ± 14% | |
| endothelial cell of artery | 8 studies | 29% ± 15% | |
| vein endothelial cell | 8 studies | 26% ± 17% | |
| GABAergic neuron | 6 studies | 34% ± 8% | |
| myeloid cell | 6 studies | 23% ± 5% | |
| T cell | 6 studies | 24% ± 8% | |
| type II pneumocyte | 6 studies | 31% ± 8% | |
| monocyte | 6 studies | 38% ± 17% | |
| plasmacytoid dendritic cell | 6 studies | 19% ± 2% | |
| interneuron | 5 studies | 36% ± 17% | |
| mesothelial cell | 5 studies | 40% ± 16% | |
| ciliated cell | 5 studies | 24% ± 8% | |
| endothelial cell of vascular tree | 5 studies | 38% ± 15% | |
| epithelial cell | 4 studies | 25% ± 11% | |
| lymphocyte | 4 studies | 26% ± 8% | |
| myofibroblast cell | 4 studies | 28% ± 6% | |
| club cell | 4 studies | 21% ± 3% | |
| classical monocyte | 3 studies | 19% ± 1% | |
| conventional dendritic cell | 3 studies | 31% ± 7% | |
| glial cell | 3 studies | 36% ± 9% | |
| granule cell | 3 studies | 23% ± 7% | |
| microglial cell | 3 studies | 24% ± 8% | |
| neuron | 3 studies | 39% ± 17% | |
| muscle cell | 3 studies | 28% ± 15% | |
| glutamatergic neuron | 3 studies | 37% ± 6% | |
| connective tissue cell | 3 studies | 24% ± 4% | |
| alveolar macrophage | 3 studies | 32% ± 6% | |
| natural killer cell | 3 studies | 24% ± 2% | |
| basal cell | 3 studies | 32% ± 17% | |
| mural cell | 3 studies | 39% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 3746.68 | 2633 / 2642 | 99% | 68.09 | 701 / 705 |
| ovary | 100% | 3147.51 | 180 / 180 | 99% | 34.68 | 424 / 430 |
| skin | 99% | 3504.49 | 1799 / 1809 | 99% | 42.75 | 468 / 472 |
| breast | 100% | 5554.81 | 459 / 459 | 99% | 41.04 | 1102 / 1118 |
| lung | 100% | 7695.93 | 578 / 578 | 94% | 27.61 | 1090 / 1155 |
| thymus | 100% | 4412.50 | 652 / 653 | 91% | 40.64 | 549 / 605 |
| kidney | 100% | 3574.54 | 89 / 89 | 89% | 28.06 | 804 / 901 |
| prostate | 99% | 2985.07 | 243 / 245 | 85% | 16.96 | 427 / 502 |
| esophagus | 92% | 2440.09 | 1333 / 1445 | 92% | 26.20 | 168 / 183 |
| uterus | 100% | 4149.19 | 170 / 170 | 80% | 16.87 | 369 / 459 |
| bladder | 100% | 3295.29 | 21 / 21 | 74% | 13.26 | 373 / 504 |
| adrenal gland | 98% | 2899.47 | 254 / 258 | 68% | 12.15 | 156 / 230 |
| liver | 89% | 1353.45 | 202 / 226 | 77% | 14.01 | 312 / 406 |
| intestine | 93% | 2192.59 | 898 / 966 | 70% | 11.16 | 367 / 527 |
| stomach | 80% | 1454.28 | 287 / 359 | 79% | 14.61 | 226 / 286 |
| pancreas | 43% | 541.94 | 141 / 328 | 94% | 19.51 | 167 / 178 |
| adipose | 100% | 6435.16 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 8465.90 | 1335 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 100% | 3992.90 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 93% | 1793.90 | 803 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 91% | 22.23 | 73 / 80 |
| peripheral blood | 87% | 3908.24 | 811 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 15.38 | 39 / 45 |
| muscle | 53% | 675.65 | 422 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 48% | 5.39 | 14 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0097190 | Biological process | apoptotic signaling pathway |
| GO_0006919 | Biological process | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| GO_0006897 | Biological process | endocytosis |
| GO_0048260 | Biological process | positive regulation of receptor-mediated endocytosis |
| GO_0045742 | Biological process | positive regulation of epidermal growth factor receptor signaling pathway |
| GO_0048268 | Biological process | clathrin coat assembly |
| GO_0042981 | Biological process | regulation of apoptotic process |
| GO_0030154 | Biological process | cell differentiation |
| GO_0050821 | Biological process | protein stabilization |
| GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
| GO_0007015 | Biological process | actin filament organization |
| GO_0099149 | Biological process | regulation of postsynaptic neurotransmitter receptor internalization |
| GO_0030100 | Biological process | regulation of endocytosis |
| GO_0006915 | Biological process | apoptotic process |
| GO_0051897 | Biological process | positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0099637 | Biological process | neurotransmitter receptor transport |
| GO_2000588 | Biological process | positive regulation of platelet-derived growth factor receptor-beta signaling pathway |
| GO_0098978 | Cellular component | glutamatergic synapse |
| GO_0098793 | Cellular component | presynapse |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0098685 | Cellular component | Schaffer collateral - CA1 synapse |
| GO_0016020 | Cellular component | membrane |
| GO_0030136 | Cellular component | clathrin-coated vesicle |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0030864 | Cellular component | cortical actin cytoskeleton |
| GO_0098794 | Cellular component | postsynapse |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030665 | Cellular component | clathrin-coated vesicle membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0035612 | Molecular function | AP-2 adaptor complex binding |
| GO_0032051 | Molecular function | clathrin light chain binding |
| GO_0005154 | Molecular function | epidermal growth factor receptor binding |
| GO_0005200 | Molecular function | structural constituent of cytoskeleton |
| GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
| GO_0051015 | Molecular function | actin filament binding |
| GO_0035091 | Molecular function | phosphatidylinositol binding |
| GO_0032266 | Molecular function | phosphatidylinositol-3-phosphate binding |
| GO_0035615 | Molecular function | clathrin adaptor activity |
| GO_0030276 | Molecular function | clathrin binding |
| GO_0035254 | Molecular function | glutamate receptor binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0080025 | Molecular function | phosphatidylinositol-3,5-bisphosphate binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0043325 | Molecular function | phosphatidylinositol-3,4-bisphosphate binding |
| Gene name | HIP1 |
| Protein name | Huntingtin interacting protein 1 HIP1 protein Huntingtin-interacting protein 1 Huntingtin-interacting protein 1 (HIP-1) (Huntingtin-interacting protein I) (HIP-I) |
| Synonyms | |
| Description | FUNCTION: Plays a role in clathrin-mediated endocytosis and trafficking . Involved in regulating AMPA receptor trafficking in the central nervous system in an NMDA-dependent manner (By similarity). Regulates presynaptic nerve terminal activity (By similarity). Enhances androgen receptor (AR)-mediated transcription . May act as a proapoptotic protein that induces cell death by acting through the intrinsic apoptosis pathway . Binds 3-phosphoinositides (via ENTH domain) . May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis . May play a functional role in the cell filament networks . May be required for differentiation, proliferation, and/or survival of somatic and germline progenitors . . |
| Accessions | ENST00000434438.6 [O00291-3] ENST00000336926.11 [O00291-1] Q8TDA4 C9JMG5 ENST00000616821.4 [O00291-4] O00291 A4VCI6 ENST00000420909.1 |