TRAF7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of TRAF7 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0007219Biological processNotch signaling pathway
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0000027Biological processribosomal large subunit assembly
GO_0043410Biological processpositive regulation of MAPK cascade
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0006915Biological processapoptotic process
GO_2001235Biological processpositive regulation of apoptotic signaling pathway
GO_0035519Biological processprotein K29-linked ubiquitination
GO_0005730Cellular componentnucleolus
GO_0000151Cellular componentubiquitin ligase complex
GO_0005886Cellular componentplasma membrane
GO_0031410Cellular componentcytoplasmic vesicle
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0008270Molecular functionzinc ion binding
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAF7
Protein nameE3 ubiquitin-protein ligase TRAF7 (EC 2.3.2.-) (EC 2.3.2.27) (RING finger and WD repeat-containing protein 1) (RING finger protein 119) (RING-type E3 ubiquitin transferase TRAF7) (TNF receptor-associated factor 7)
TNF receptor associated factor 7
TNF receptor-associated factor 7
SynonymsRNF119
RFWD1
DescriptionFUNCTION: E3 ubiquitin and SUMO-protein ligase that plays a role in different biological processes such as innate immunity, inflammation or apoptosis . Potentiates MAP3K3-mediated activation of JUN/AP1 and DDIT3 transcriptional regulators . Negatively regulates MYB transcriptional activity by sequestering it to the cytosol via SUMOylation (By similarity). Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3. Negatively regulates RLR-mediated innate immunity by promoting 'Lys-48'-linked ubiquitination of TBK1 through its RING domain to inhibit the cellular antiviral response . Promotes 'Lys-29'-linked polyubiquitination of NEMO/IKBKG and RELA leading to targeting these two proteins to lysosomal degradative pathways, reducing the transcriptional activity of NF-kappa-B . .

AccessionsENST00000326181.11 [Q6Q0C0-1]
Q6Q0C0
ENST00000704452.1 [Q6Q0C0-1]
ENST00000567645.2
A0A994J4N1
ENST00000567653.5
A0A286SD37
ENST00000564067.5
H3BR17
A0A087WUB0
ENST00000704453.1
H3BUP4
ENST00000565383.5
A0A286SD33
A0A286SD32