NEK6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0030071Biological processregulation of mitotic metaphase/anaphase transition
GO_2000772Biological processregulation of cellular senescence
GO_0007059Biological processchromosome segregation
GO_0007052Biological processmitotic spindle organization
GO_0007077Biological processmitotic nuclear membrane disassembly
GO_0051301Biological processcell division
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0051225Biological processspindle assembly
GO_0007346Biological processregulation of mitotic cell cycle
GO_0006915Biological processapoptotic process
GO_0006468Biological processprotein phosphorylation
GO_0046777Biological processprotein autophosphorylation
GO_0034451Cellular componentcentriolar satellite
GO_0005874Cellular componentmicrotubule
GO_0000922Cellular componentspindle pole
GO_0016607Cellular componentnuclear speck
GO_0005813Cellular componentcentrosome
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0140297Molecular functionDNA-binding transcription factor binding
GO_0106310Molecular functionprotein serine kinase activity
GO_0019901Molecular functionprotein kinase binding
GO_0001222Molecular functiontranscription corepressor binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0000287Molecular functionmagnesium ion binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0019894Molecular functionkinesin binding

IV. Literature review

[source]
Gene nameNEK6
Protein nameSerine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512)
NEK6-subfamily protein kinase (EC 2.7.11.34)
NIMA related kinase 6
Synonyms
DescriptionFUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression . Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis . Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 . Phosphorylates KIF11 to promote mitotic spindle formation . Involved in G2/M phase cell cycle arrest induced by DNA damage . Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence . Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression . .

AccessionsQ9HC98
ENST00000373600.7 [Q9HC98-2]
ENST00000373596.5
ENST00000425237.5
Q5TBH1
ENST00000394199.6 [Q9HC98-2]
Q5TBG4
Q5TBG7
ENST00000545174.5 [Q9HC98-1]
ENST00000444973.5
Q5TBG1
ENST00000454453.5
Q5TBH0
ENST00000546191.5 [Q9HC98-1]
Q5TBG2
Q5TBH2
ENST00000447379.1
ENST00000540326.5 [Q9HC98-3]
ENST00000539416.5 [Q9HC98-4]
ENST00000423785.5
ENST00000422297.5
ENST00000373603.5 [Q9HC98-1]
ENST00000320246.10 [Q9HC98-1]