Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 11 studies | 29% ± 9% | |
| astrocyte | 9 studies | 30% ± 13% | |
| microglial cell | 6 studies | 28% ± 8% | |
| myeloid cell | 6 studies | 23% ± 7% | |
| mast cell | 6 studies | 24% ± 7% | |
| dendritic cell | 5 studies | 23% ± 6% | |
| conventional dendritic cell | 4 studies | 22% ± 5% | |
| epithelial cell | 4 studies | 26% ± 9% | |
| fibroblast | 4 studies | 18% ± 4% | |
| monocyte | 4 studies | 33% ± 20% | |
| abnormal cell | 4 studies | 29% ± 6% | |
| hepatocyte | 4 studies | 42% ± 24% | |
| alveolar macrophage | 4 studies | 27% ± 12% | |
| classical monocyte | 3 studies | 17% ± 2% | |
| endothelial cell | 3 studies | 25% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| stomach | 100% | 1323.35 | 358 / 359 | 100% | 58.11 | 286 / 286 |
| liver | 100% | 4310.30 | 226 / 226 | 100% | 43.59 | 404 / 406 |
| intestine | 100% | 1743.78 | 965 / 966 | 99% | 58.29 | 524 / 527 |
| prostate | 100% | 1959.42 | 244 / 245 | 99% | 42.72 | 498 / 502 |
| lung | 100% | 2516.72 | 577 / 578 | 99% | 48.38 | 1139 / 1155 |
| breast | 100% | 1693.18 | 458 / 459 | 98% | 47.49 | 1099 / 1118 |
| brain | 97% | 2204.04 | 2567 / 2642 | 99% | 61.53 | 698 / 705 |
| pancreas | 97% | 1382.02 | 319 / 328 | 94% | 44.15 | 168 / 178 |
| kidney | 96% | 1818.61 | 85 / 89 | 90% | 76.90 | 812 / 901 |
| esophagus | 87% | 867.25 | 1261 / 1445 | 95% | 40.35 | 174 / 183 |
| uterus | 98% | 1013.10 | 166 / 170 | 83% | 24.61 | 383 / 459 |
| skin | 83% | 2290.40 | 1493 / 1809 | 98% | 58.53 | 464 / 472 |
| bladder | 100% | 2450.00 | 21 / 21 | 77% | 30.23 | 389 / 504 |
| ovary | 81% | 740.78 | 146 / 180 | 96% | 36.89 | 412 / 430 |
| thymus | 98% | 961.65 | 637 / 653 | 64% | 13.37 | 390 / 605 |
| adrenal gland | 86% | 648.81 | 221 / 258 | 19% | 6.29 | 44 / 230 |
| adipose | 100% | 1843.49 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 65.72 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 68.69 | 29 / 29 |
| spleen | 100% | 1449.53 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 20.47 | 1 / 1 |
| blood vessel | 99% | 1821.02 | 1327 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 89% | 4206.91 | 826 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 18.00 | 39 / 45 |
| heart | 60% | 436.03 | 513 / 861 | 0% | 0 | 0 / 0 |
| muscle | 39% | 220.47 | 310 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0018105 | Biological process | peptidyl-serine phosphorylation |
| GO_0030071 | Biological process | regulation of mitotic metaphase/anaphase transition |
| GO_2000772 | Biological process | regulation of cellular senescence |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0007052 | Biological process | mitotic spindle organization |
| GO_0007077 | Biological process | mitotic nuclear membrane disassembly |
| GO_0051301 | Biological process | cell division |
| GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
| GO_0051225 | Biological process | spindle assembly |
| GO_0007346 | Biological process | regulation of mitotic cell cycle |
| GO_0006915 | Biological process | apoptotic process |
| GO_0006468 | Biological process | protein phosphorylation |
| GO_0046777 | Biological process | protein autophosphorylation |
| GO_0034451 | Cellular component | centriolar satellite |
| GO_0005874 | Cellular component | microtubule |
| GO_0000922 | Cellular component | spindle pole |
| GO_0016607 | Cellular component | nuclear speck |
| GO_0005813 | Cellular component | centrosome |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0140297 | Molecular function | DNA-binding transcription factor binding |
| GO_0106310 | Molecular function | protein serine kinase activity |
| GO_0019901 | Molecular function | protein kinase binding |
| GO_0001222 | Molecular function | transcription corepressor binding |
| GO_0004674 | Molecular function | protein serine/threonine kinase activity |
| GO_0031625 | Molecular function | ubiquitin protein ligase binding |
| GO_0000287 | Molecular function | magnesium ion binding |
| GO_0005524 | Molecular function | ATP binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0019894 | Molecular function | kinesin binding |
| Gene name | NEK6 |
| Protein name | Serine/threonine-protein kinase Nek6 (EC 2.7.11.34) (Never in mitosis A-related kinase 6) (NimA-related protein kinase 6) (Protein kinase SID6-1512) NEK6-subfamily protein kinase (EC 2.7.11.34) NIMA related kinase 6 |
| Synonyms | |
| Description | FUNCTION: Protein kinase which plays an important role in mitotic cell cycle progression . Required for chromosome segregation at metaphase-anaphase transition, robust mitotic spindle formation and cytokinesis . Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3 . Phosphorylates KIF11 to promote mitotic spindle formation . Involved in G2/M phase cell cycle arrest induced by DNA damage . Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence . Phosphorylates EML4 at 'Ser-144', promoting its dissociation from microtubules during mitosis which is required for efficient chromosome congression . . |
| Accessions | Q9HC98 ENST00000373600.7 [Q9HC98-2] ENST00000373596.5 ENST00000425237.5 Q5TBH1 ENST00000394199.6 [Q9HC98-2] Q5TBG4 Q5TBG7 ENST00000545174.5 [Q9HC98-1] ENST00000444973.5 Q5TBG1 ENST00000454453.5 Q5TBH0 ENST00000546191.5 [Q9HC98-1] Q5TBG2 Q5TBH2 ENST00000447379.1 ENST00000540326.5 [Q9HC98-3] ENST00000539416.5 [Q9HC98-4] ENST00000423785.5 ENST00000422297.5 ENST00000373603.5 [Q9HC98-1] ENST00000320246.10 [Q9HC98-1] |