CIAPIN1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0016226Biological processiron-sulfur cluster assembly
GO_0043066Biological processnegative regulation of apoptotic process
GO_0030097Biological processhemopoiesis
GO_0005730Cellular componentnucleolus
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005739Cellular componentmitochondrion
GO_0051537Molecular function2 iron, 2 sulfur cluster binding
GO_0005506Molecular functioniron ion binding
GO_0005515Molecular functionprotein binding
GO_0051539Molecular function4 iron, 4 sulfur cluster binding
GO_0009055Molecular functionelectron transfer activity

IV. Literature review

[source]
Gene nameCIAPIN1
Protein nameCytokine induced apoptosis inhibitor 1
Anamorsin (Cytokine-induced apoptosis inhibitor 1) (Fe-S cluster assembly protein DRE2 homolog)
SynonymsPRO0915
CUA001
DescriptionFUNCTION: Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1 . NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit (By similarity). Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells (By similarity). .

AccessionsENST00000568940.5
ENST00000569979.5
ENST00000567518.5 [Q6FI81-3]
H3BUG4
ENST00000569370.5
ENST00000565786.5
H3BT65
ENST00000563341.1
ENST00000570000.5
H3BV90
ENST00000394391.9 [Q6FI81-1]
Q6FI81
ENST00000565961.5
H3BTZ8
H3BTT4
H3BPG7
H3BQ23
ENST00000567751.5