CCAR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0030335Biological processpositive regulation of cell migration
GO_0006915Biological processapoptotic process
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0005641Cellular componentnuclear envelope lumen
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0003723Molecular functionRNA binding
GO_0003713Molecular functiontranscription coactivator activity
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCCAR1
Protein nameCell division cycle and apoptosis regulator protein 1 (Cell cycle and apoptosis regulatory protein 1) (CARP-1) (Death inducer with SAP domain)
Cell division cycle and apoptosis regulator 1
SynonymsDIS
CARP1
DescriptionFUNCTION: Associates with components of the Mediator and p160 coactivator complexes that play a role as intermediaries transducing regulatory signals from upstream transcriptional activator proteins to basal transcription machinery at the core promoter. Recruited to endogenous nuclear receptor target genes in response to the appropriate hormone. Also functions as a p53 coactivator. May thus play an important role in transcriptional regulation (By similarity). May be involved in apoptosis signaling in the presence of the reinoid CD437. Apoptosis induction involves sequestration of 14-3-3 protein(s) and mediated altered expression of multiple cell cycle regulatory genes including MYC, CCNB1 and CDKN1A. Plays a role in cell cycle progression and/or cell proliferation . In association with CALCOCO1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells . Can act as a both a coactivator and corepressor of AR-mediated transcription. Contributes to chromatin looping and AR transcription complex assembly by stabilizing AR-GATA2 association on chromatin and facilitating MED1 and RNA polymerase II recruitment to AR-binding sites. May play an important role in the growth and tumorigenesis of prostate cancer cells . .

AccessionsENST00000540210.5
F5H3E1
H0YFJ7
F5H3I8
ENST00000538031.5
ENST00000265872.11 [Q8IX12-1]
ENST00000543225.5
A0A0C4DGG8
F5H7M9
ENST00000630771.2
H0YFT7
ENST00000543706.1
F5H1H2
ENST00000543229.5
ENST00000536391.5
Q8IX12
F5H2E6
F5H1L3
ENST00000536012.5
ENST00000541012.5
F5H808
ENST00000479143.2
ENST00000539539.5
ENST00000543719.5 [Q8IX12-2]
ENST00000494903.2