SUDS3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_0006915Biological processapoptotic process
GO_0030336Biological processnegative regulation of cell migration
GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0021762Biological processsubstantia nigra development
GO_0070822Cellular componentSin3-type complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0004407Molecular functionhistone deacetylase activity
GO_0019899Molecular functionenzyme binding
GO_0005515Molecular functionprotein binding
GO_0042826Molecular functionhistone deacetylase binding

IV. Literature review

[source]
Gene nameSUDS3
Protein nameSUDS3 protein
Sin3 histone deacetylase corepressor complex component SDS3 (45 kDa Sin3-associated polypeptide) (Suppressor of defective silencing 3 protein homolog)
SynonymsSDS3
SAP45
DescriptionFUNCTION: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. .

AccessionsQ9H7L9
Q2M2F3
ENST00000543473.2
Q52LB7