GHITM | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
natural killer cell	35 studies	32% ± 9%	Explore
B cell	31 studies	28% ± 9%	Explore
fibroblast	29 studies	28% ± 12%	Explore
CD8-positive, alpha-beta T cell	29 studies	33% ± 11%	Explore
endothelial cell	28 studies	30% ± 13%	Explore
CD4-positive, alpha-beta T cell	28 studies	33% ± 12%	Explore
macrophage	27 studies	30% ± 10%	Explore
conventional dendritic cell	27 studies	37% ± 15%	Explore
T cell	25 studies	31% ± 9%	Explore
smooth muscle cell	24 studies	30% ± 9%	Explore
pericyte	24 studies	32% ± 11%	Explore
non-classical monocyte	22 studies	38% ± 14%	Explore
classical monocyte	21 studies	34% ± 11%	Explore
basal cell	20 studies	32% ± 17%	Explore
regulatory T cell	20 studies	35% ± 9%	Explore
memory B cell	19 studies	26% ± 9%	Explore
epithelial cell	19 studies	36% ± 20%	Explore
plasmacytoid dendritic cell	18 studies	33% ± 12%	Explore
monocyte	17 studies	32% ± 10%	Explore
naive B cell	17 studies	24% ± 7%	Explore
gamma-delta T cell	17 studies	33% ± 13%	Explore
ciliated cell	16 studies	36% ± 14%	Explore
mature NK T cell	16 studies	33% ± 8%	Explore
dendritic cell	15 studies	38% ± 24%	Explore
plasma cell	15 studies	42% ± 15%	Explore
CD16-positive, CD56-dim natural killer cell, human	15 studies	33% ± 9%	Explore
mast cell	14 studies	27% ± 6%	Explore
endothelial cell of lymphatic vessel	14 studies	32% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	13 studies	28% ± 7%	Explore
myofibroblast cell	13 studies	29% ± 9%	Explore
connective tissue cell	13 studies	31% ± 8%	Explore
plasmablast	11 studies	46% ± 21%	Explore
CD8-positive, alpha-beta memory T cell	11 studies	34% ± 11%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	11 studies	34% ± 7%	Explore
CD16-negative, CD56-bright natural killer cell, human	11 studies	33% ± 9%	Explore
capillary endothelial cell	11 studies	24% ± 5%	Explore
mucosal invariant T cell	11 studies	32% ± 8%	Explore
CD4-positive, alpha-beta memory T cell	10 studies	30% ± 11%	Explore
endothelial cell of artery	10 studies	24% ± 6%	Explore
endothelial cell of vascular tree	10 studies	27% ± 5%	Explore
myeloid cell	10 studies	33% ± 11%	Explore
secretory cell	9 studies	34% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	9 studies	32% ± 11%	Explore
vein endothelial cell	9 studies	22% ± 4%	Explore
leukocyte	8 studies	28% ± 8%	Explore
progenitor cell	8 studies	33% ± 11%	Explore
enterocyte	8 studies	31% ± 11%	Explore
type I pneumocyte	7 studies	27% ± 12%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	37% ± 16%	Explore
epithelial cell of proximal tubule	7 studies	46% ± 14%	Explore
goblet cell	7 studies	32% ± 11%	Explore
abnormal cell	7 studies	34% ± 8%	Explore
erythrocyte	7 studies	38% ± 22%	Explore
T follicular helper cell	7 studies	27% ± 5%	Explore
club cell	6 studies	34% ± 12%	Explore
respiratory goblet cell	6 studies	33% ± 19%	Explore
kidney loop of Henle epithelial cell	6 studies	44% ± 10%	Explore
renal alpha-intercalated cell	6 studies	61% ± 16%	Explore
neuron	6 studies	35% ± 16%	Explore
erythroblast	6 studies	38% ± 24%	Explore
transit amplifying cell	6 studies	30% ± 12%	Explore
glutamatergic neuron	6 studies	36% ± 15%	Explore
innate lymphoid cell	6 studies	31% ± 3%	Explore
astrocyte	6 studies	31% ± 17%	Explore
alveolar macrophage	5 studies	33% ± 5%	Explore
hematopoietic precursor cell	5 studies	41% ± 18%	Explore
exhausted T cell	5 studies	40% ± 7%	Explore
ionocyte	5 studies	42% ± 6%	Explore
mononuclear phagocyte	5 studies	36% ± 14%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	47% ± 7%	Explore
mesothelial cell	5 studies	31% ± 19%	Explore
retinal ganglion cell	5 studies	71% ± 32%	Explore
microglial cell	5 studies	23% ± 8%	Explore
retinal rod cell	5 studies	39% ± 16%	Explore
pro-B cell	5 studies	31% ± 8%	Explore
immature B cell	5 studies	34% ± 16%	Explore
type II pneumocyte	5 studies	35% ± 18%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	43% ± 15%	Explore
effector memory CD4-positive, alpha-beta T cell	5 studies	38% ± 14%	Explore
pancreatic A cell	4 studies	61% ± 14%	Explore
type B pancreatic cell	4 studies	64% ± 21%	Explore
enteroendocrine cell	4 studies	40% ± 17%	Explore
intestinal crypt stem cell	4 studies	32% ± 9%	Explore
retinal cone cell	4 studies	51% ± 18%	Explore
hematopoietic stem cell	4 studies	29% ± 8%	Explore
precursor B cell	4 studies	41% ± 11%	Explore
amacrine cell	4 studies	45% ± 17%	Explore
retina horizontal cell	4 studies	39% ± 19%	Explore
CD4-positive helper T cell	4 studies	23% ± 9%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	32% ± 6%	Explore
granulocyte	4 studies	27% ± 11%	Explore
GABAergic neuron	4 studies	38% ± 4%	Explore
T-helper 17 cell	4 studies	35% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	32% ± 10%	Explore
duct epithelial cell	3 studies	31% ± 6%	Explore
squamous epithelial cell	3 studies	41% ± 24%	Explore
pancreatic D cell	3 studies	66% ± 20%	Explore
glomerular endothelial cell	3 studies	24% ± 9%	Explore
podocyte	3 studies	44% ± 5%	Explore
neural crest cell	3 studies	26% ± 4%	Explore
retinal bipolar neuron	3 studies	49% ± 18%	Explore
OFF-bipolar cell	3 studies	54% ± 30%	Explore
ON-bipolar cell	3 studies	53% ± 32%	Explore
renal principal cell	3 studies	45% ± 7%	Explore
extravillous trophoblast	3 studies	25% ± 7%	Explore
placental villous trophoblast	3 studies	51% ± 13%	Explore
lymphocyte	3 studies	38% ± 6%	Explore
neuroendocrine cell	3 studies	41% ± 13%	Explore
serous secreting cell	3 studies	31% ± 4%	Explore
intraepithelial lymphocyte	3 studies	38% ± 12%	Explore
Mueller cell	3 studies	43% ± 4%	Explore
germinal center B cell	3 studies	31% ± 5%	Explore
intermediate monocyte	3 studies	48% ± 21%	Explore
IgG plasma cell	3 studies	24% ± 9%	Explore
pancreatic ductal cell	3 studies	71% ± 14%	Explore
oligodendrocyte precursor cell	3 studies	29% ± 8%	Explore
neutrophil	3 studies	18% ± 2%	Explore
glial cell	3 studies	32% ± 19%	Explore
group 3 innate lymphoid cell	3 studies	39% ± 13%	Explore
keratinocyte	3 studies	27% ± 2%	Explore
T-helper 1 cell	3 studies	40% ± 8%	Explore
double negative thymocyte	3 studies	48% ± 16%	Explore
progenitor cell of mammary luminal epithelium	3 studies	23% ± 1%	Explore
hepatocyte	3 studies	47% ± 24%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	18 studies	32% ± 11%	Explore
lung	16 studies	35% ± 14%	Explore
intestine	12 studies	27% ± 12%	Explore
kidney	9 studies	35% ± 10%	Explore
brain	9 studies	26% ± 10%	Explore
eye	7 studies	40% ± 14%	Explore
liver	7 studies	32% ± 23%	Explore
bone marrow	5 studies	22% ± 5%	Explore
pancreas	4 studies	60% ± 19%	Explore
placenta	4 studies	29% ± 14%	Explore
uterus	4 studies	35% ± 12%	Explore
lymph node	4 studies	33% ± 10%	Explore
breast	4 studies	26% ± 3%	Explore
adrenal gland	3 studies	28% ± 5%	Explore
prostate	3 studies	23% ± 8%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	9509.31	1445 / 1445	100%	224.99	183 / 183
liver	100%	10861.22	226 / 226	100%	232.72	406 / 406
stomach	100%	9449.57	359 / 359	100%	257.84	286 / 286
brain	100%	13391.42	2638 / 2642	100%	245.12	705 / 705
breast	100%	8493.57	459 / 459	100%	287.26	1116 / 1118
intestine	100%	11871.05	966 / 966	100%	310.89	526 / 527
uterus	100%	7064.64	170 / 170	100%	231.76	458 / 459
kidney	100%	15311.84	89 / 89	100%	288.55	898 / 901
bladder	100%	8258.38	21 / 21	100%	241.45	502 / 504
lung	99%	7842.36	574 / 578	100%	251.60	1154 / 1155
thymus	100%	7760.14	651 / 653	100%	230.16	602 / 605
adrenal gland	100%	17553.22	258 / 258	99%	381.27	228 / 230
prostate	100%	6268.13	244 / 245	99%	211.24	499 / 502
skin	100%	8650.49	1807 / 1809	99%	201.83	467 / 472
ovary	100%	6379.96	180 / 180	99%	176.50	424 / 430
pancreas	95%	3708.11	312 / 328	100%	196.85	178 / 178
adipose	100%	9208.65	1204 / 1204	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	236.10	29 / 29
muscle	100%	18154.91	803 / 803	0%	0	0 / 0
spleen	100%	7342.06	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	237.59	45 / 45
ureter	0%	0	0 / 0	100%	75.46	1 / 1
blood vessel	100%	9436.86	1333 / 1335	0%	0	0 / 0
heart	96%	17404.14	829 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	96%	169.49	77 / 80
peripheral blood	96%	8426.13	894 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006915	Biological process	apoptotic process
GO_0090201	Biological process	negative regulation of release of cytochrome c from mitochondria
GO_0140141	Biological process	mitochondrial potassium ion transmembrane transport
GO_1905448	Biological process	positive regulation of mitochondrial ATP synthesis coupled electron transport
GO_0099093	Biological process	calcium export from the mitochondrion
GO_0006851	Biological process	mitochondrial calcium ion transmembrane transport
GO_0007007	Biological process	inner mitochondrial membrane organization
GO_0006816	Biological process	calcium ion transport
GO_1902600	Biological process	proton transmembrane transport
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0070062	Cellular component	extracellular exosome
GO_0005739	Cellular component	mitochondrion
GO_0015369	Molecular function	calcium:proton antiporter activity
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

IV. Literature review

[source]

Gene name	GHITM
Protein name	Growth hormone-inducible transmembrane protein (Dermal papilla-derived protein 2) (Mitochondrial morphology and cristae structure 1) (MICS1) (Transmembrane BAX inhibitor motif-containing protein 5) GHITM protein
Synonyms	MICS1 My021 UNQ244/PRO281 DERP2 TMBIM5
Description	FUNCTION: Plays an important role in maintenance of mitochondrial morphology and in mediating either calcium or potassium/proton antiport . Mediates proton-dependent calcium efflux from mitochondrion . Functions also as an electroneutral mitochondrial proton/potassium exchanger . Required for the mitochondrial tubular network and cristae organization . Involved in apoptotic release of cytochrome c . Inhibits the proteolytic activity of AFG3L2, stimulating respiration and stabilizing respiratory enzymes in actively respiring mitochondria . However, when mitochondria become hyperpolarized, GHITM loses its inhibitory activity toward AFG3L2 and the now the active AFG3L2 turns first on GHITM and, if hyperpolarization persists, on other proteins of the mitochondria, leading to a broad remodeling of the mitochondrial proteome . .
Accessions	ENST00000372134.6 ENST00000691609.1 ENST00000690283.1 Q6FIA7 Q9H3K2 ENST00000688802.1 ENST00000686583.1 ENST00000687085.1 ENST00000686247.1 ENST00000690067.1 ENST00000690920.1 ENST00000691155.1

GHITM report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review