LCN2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0015891Biological processsiderophore transport
GO_0120162Biological processpositive regulation of cold-induced thermogenesis
GO_0042742Biological processdefense response to bacterium
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_1903981Molecular functionenterobactin binding
GO_0140315Molecular functioniron ion sequestering activity
GO_0005506Molecular functioniron ion binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameLCN2
Protein nameNeutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)
Lipocalin 2
SynonymsHNL
NGAL
DescriptionFUNCTION: Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development . Binds iron through association with 2,3-dihydroxybenzoic acid (2,3-DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, inducing expression of the proapoptotic protein BCL2L11/BIM, resulting in apoptosis (By similarity). Involved in innate immunity; limits bacterial proliferation by sequestering iron bound to microbial siderophores, such as enterobactin . Can also bind siderophores from M.tuberculosis . .

AccessionsX6R8F3
ENST00000277480.7 [P80188-1]
P80188
ENST00000373017.5 [P80188-1]
ENST00000372998.1