SLC40A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006366Biological processtranscription by RNA polymerase II
GO_0034755Biological processiron ion transmembrane transport
GO_0002260Biological processlymphocyte homeostasis
GO_0060586Biological processmulticellular organismal-level iron ion homeostasis
GO_0051649Biological processestablishment of localization in cell
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006879Biological processintracellular iron ion homeostasis
GO_0003158Biological processendothelium development
GO_0006915Biological processapoptotic process
GO_0060345Biological processspleen trabecula formation
GO_1903988Biological processiron ion export across plasma membrane
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0008021Cellular componentsynaptic vesicle
GO_0005737Cellular componentcytoplasm
GO_0015093Molecular functionferrous iron transmembrane transporter activity
GO_0017046Molecular functionpeptide hormone binding
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005381Molecular functioniron ion transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC40A1
Protein namePutative ferroportin 1 variant IIIB
Solute carrier family 40 member
Putative ferroportin 1 variant IIIA
Solute carrier family 40 member 1
Solute carrier family 40 member 1 (Ferroportin-1) (Iron-regulated transporter 1)
Ferroportin 1 variant I (Ferroportin 1 variant IIB) (Solute carrier family 40 member 1)
Putative ferroportin 1 variant IIIC
SynonymsFPN
IREG1
SLC11A3
FPN1
MSTP079
DescriptionFUNCTION: Transports Fe(2+) from the inside of a cell to the outside of the cell, playing a key role for maintaining systemic iron homeostasis . Transports iron from intestinal, splenic, hepatic cells, macrophages and erythrocytes into the blood to provide iron to other tissues (By similarity). Controls therefore dietary iron uptake, iron recycling by macrophages and erythrocytes, and release of iron stores in hepatocytes (By similarity). When iron is in excess in serum, circulating HAMP/hepcidin levels increase resulting in a degradation of SLC40A1, thus limiting the iron efflux to plasma . .

FUNCTION: May be involved in iron transport and iron homeostasis. .

FUNCTION: May be involved in iron transport and iron homeostasis. .

FUNCTION: May be involved in iron transport and iron homeostasis. .

FUNCTION: May be involved in iron transport and iron homeostasis. .

FUNCTION: May be involved in iron transport and iron homeostasis. .

AccessionsQ4PNE4
ENST00000427241.5
A0A1B1FKG8
A0A1B1FKH1
Q4PNE2
Q4PNE3
E7ES28
ENST00000427419.5
Q9NP59
ENST00000455320.5
ENST00000261024.7
E7EQF8
ENST00000440626.1
D7GLE3
A0A1B1FKG5
Q4PNE6