BOK report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008635Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c
GO_0051480Biological processregulation of cytosolic calcium ion concentration
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_1901030Biological processpositive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_1901382Biological processregulation of chorionic trophoblast cell proliferation
GO_1904708Biological processregulation of granulosa cell apoptotic process
GO_2001244Biological processpositive regulation of intrinsic apoptotic signaling pathway
GO_0006921Biological processcellular component disassembly involved in execution phase of apoptosis
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0051259Biological processprotein complex oligomerization
GO_0051402Biological processneuron apoptotic process
GO_1902237Biological processpositive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
GO_0010506Biological processregulation of autophagy
GO_0060546Biological processnegative regulation of necroptotic process
GO_0072332Biological processintrinsic apoptotic signaling pathway by p53 class mediator
GO_0051902Biological processnegative regulation of mitochondrial depolarization
GO_0097192Biological processextrinsic apoptotic signaling pathway in absence of ligand
GO_0008630Biological processintrinsic apoptotic signaling pathway in response to DNA damage
GO_1903899Biological processpositive regulation of PERK-mediated unfolded protein response
GO_0001836Biological processrelease of cytochrome c from mitochondria
GO_0048709Biological processoligodendrocyte differentiation
GO_0008584Biological processmale gonad development
GO_0006915Biological processapoptotic process
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0043065Biological processpositive regulation of apoptotic process
GO_1900119Biological processpositive regulation of execution phase of apoptosis
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005739Cellular componentmitochondrion
GO_0031966Cellular componentmitochondrial membrane
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0005640Cellular componentnuclear outer membrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0033106Cellular componentcis-Golgi network membrane
GO_0005737Cellular componentcytoplasm
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0005102Molecular functionsignaling receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0051400Molecular functionBH domain binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBOK
Protein nameBCL-2-related ovarian killer protein isoform 6 transcript variant 16 (BCL-2-related ovarian killer protein isoform 6 transcript variant 17) (BCL-2-related ovarian killer protein isoform 6 transcript variant 18)
Bcl-2-related ovarian killer protein isoform 5
BCL2-related ovarian killer, isoform CRA_a (Bcl-2-related ovarian killer protein isoform 1)
Uncharacterized protein BOK
Bcl-2-related ovarian killer protein isoform 7 (BCL-2-related ovarian killer protein isoform 7 transcript variant 24) (BCL2-related ovarian killer, isoform CRA_c)
Bcl-2-related ovarian killer protein isoform 4
Bcl-2-related ovarian killer protein (hBOK) (Bcl-2-like protein 9) (Bcl2-L-9)
Bcl-2-related ovarian killer protein isoform 3
Bcl-2 related ovarian killer
SynonymshCG_33052
BCL2L9
BOKL
DescriptionFUNCTION: [Isoform 1]: Apoptosis regulator that functions through different apoptotic signaling pathways . Plays a roles as pro-apoptotic protein that positively regulates intrinsic apoptotic process in a BAX- and BAK1-dependent manner or in a BAX- and BAK1-independent manner . In response to endoplasmic reticulum stress promotes mitochondrial apoptosis through downstream BAX/BAK1 activation and positive regulation of PERK-mediated unfolded protein response (By similarity). Activates apoptosis independently of heterodimerization with survival-promoting BCL2 and BCL2L1 through induction of mitochondrial outer membrane permeabilization, in a BAX- and BAK1-independent manner, in response to inhibition of ERAD-proteasome degradation system, resulting in cytochrome c release . In response to DNA damage, mediates intrinsic apoptotic process in a TP53-dependent manner . Plays a role in granulosa cell apoptosis by CASP3 activation . Plays a roles as anti-apoptotic protein during neuronal apoptotic process, by negatively regulating poly ADP-ribose polymerase-dependent cell death through regulation of neuronal calcium homeostasis and mitochondrial bioenergetics in response to NMDA excitation (By similarity). In addition to its role in apoptosis, may regulate trophoblast cell proliferation during the early stages of placental development, by acting on G1/S transition through regulation of CCNE1 expression . May also play a role as an inducer of autophagy by disrupting interaction between MCL1 and BECN1 . .; FUNCTION: [Isoform 2]: Pro-apoptotic molecule exerting its function through the mitochondrial pathway. .

AccessionsA0A481T0M5
ENST00000318407.5 [Q9UMX3-1]
Q53QM7
A0A4D6NVJ5
Q53NU8
Q9UL32
A0A4D6NU76
Q9UMX3
A0A024R4A8
A0A481T0W6
A0A481T0B6