AREL1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070979Biological processprotein K11-linked ubiquitination
GO_1990390Biological processprotein K33-linked ubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0000209Biological processprotein polyubiquitination
GO_0050727Biological processregulation of inflammatory response
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0004842Molecular functionubiquitin-protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAREL1
Protein nameApoptosis resistant E3 ubiquitin protein ligase 1
Apoptosis-resistant E3 ubiquitin protein ligase 1 (EC 2.3.2.26) (Apoptosis-resistant HECT-type E3 ubiquitin transferase 1)
HECT-type E3 ubiquitin transferase (EC 2.3.2.26)
SynonymsKIAA0317
DescriptionFUNCTION: E3 ubiquitin-protein ligase that catalyzes 'Lys-11'- or 'Lys-33'-linked polyubiquitin chains, with some preference for 'Lys-33' linkages . E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates . Ubiquitinates SEPTIN4, DIABLO/SMAC and HTRA2 in vitro . Modulates pulmonary inflammation by targeting SOCS2 for ubiquitination and subsequent degradation by the proteasome . .

AccessionsO15033
ENST00000481010.6
ENST00000556202.5
A0A7P0Z4H7
H0YJ69
ENST00000555249.1
ENST00000356357.9 [O15033-1]
G3V5P7
ENST00000555330.5
ENST00000681535.1
A0A7P0T811
ENST00000554070.1
G3V245
ENST00000681099.1
H0YJ67
G3V2B5
G3V506
ENST00000681599.1 [O15033-1]
ENST00000553279.5