BABAM2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0010212Biological processresponse to ionizing radiation
GO_0045739Biological processpositive regulation of DNA repair
GO_0006302Biological processdouble-strand break repair
GO_0007165Biological processsignal transduction
GO_0006282Biological processregulation of DNA repair
GO_0006974Biological processDNA damage response
GO_0051301Biological processcell division
GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0070536Biological processprotein K63-linked deubiquitination
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006915Biological processapoptotic process
GO_2000001Biological processregulation of DNA damage checkpoint
GO_0071479Biological processcellular response to ionizing radiation
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0070531Cellular componentBRCA1-A complex
GO_0070552Cellular componentBRISC complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000152Cellular componentnuclear ubiquitin ligase complex
GO_0000268Molecular functionperoxisome targeting sequence binding
GO_0005164Molecular functiontumor necrosis factor receptor binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBABAM2
Protein nameUpstream ORF
Alternative protein BRE
BRISC and BRCA1-A complex member 2 (BRCA1-A complex subunit BRE) (BRCA1/BRCA2-containing complex subunit 45) (Brain and reproductive organ-expressed protein)
BRISC and BRCA1-A complex member 2
SynonymsBRCC45
BRE
DescriptionFUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX . In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer . Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates . Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity . The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression . Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination . May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect . .

FUNCTION: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. .

FUNCTION: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. .

FUNCTION: May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. .

AccessionsENST00000344773.6 [Q9NXR7-1]
Q9NXR7
ENST00000379629.7
F8W733
A0A075B7D2
ENST00000342045.6 [Q9NXR7-2]
C9J2G0
ENST00000604932.1
Q96P08
L8E9D4
ENST00000436924.5
ENST00000379624.6 [Q9NXR7-2]
ENST00000361704.6 [Q9NXR7-4]
ENST00000379632.6 [Q9NXR7-4]