CASP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1903265Biological processpositive regulation of tumor necrosis factor-mediated signaling pathway
GO_0002221Biological processpattern recognition receptor signaling pathway
GO_0071260Biological processcellular response to mechanical stimulus
GO_0046456Biological processicosanoid biosynthetic process
GO_0007165Biological processsignal transduction
GO_0140448Biological processsignaling receptor ligand precursor processing
GO_0051607Biological processdefense response to virus
GO_0016540Biological processprotein autoprocessing
GO_0070269Biological processpyroptotic inflammatory response
GO_0050727Biological processregulation of inflammatory response
GO_0043280Biological processpositive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0032731Biological processpositive regulation of interleukin-1 beta production
GO_0140970Biological processAIM2 inflammasome complex assembly
GO_0032741Biological processpositive regulation of interleukin-18 production
GO_0042981Biological processregulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0006508Biological processproteolysis
GO_0042742Biological processdefense response to bacterium
GO_0007231Biological processosmosensory signaling pathway
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0006915Biological processapoptotic process
GO_0140447Biological processcytokine precursor processing
GO_0050729Biological processpositive regulation of inflammatory response
GO_0051604Biological processprotein maturation
GO_0071346Biological processcellular response to type II interferon
GO_0072558Cellular componentNLRP1 inflammasome complex
GO_0005730Cellular componentnucleolus
GO_0072559Cellular componentNLRP3 inflammasome complex
GO_0005886Cellular componentplasma membrane
GO_0005874Cellular componentmicrotubule
GO_0072557Cellular componentIPAF inflammasome complex
GO_0032991Cellular componentprotein-containing complex
GO_0097169Cellular componentAIM2 inflammasome complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0061702Cellular componentcanonical inflammasome complex
GO_0097179Cellular componentprotease inhibitor complex
GO_0050700Molecular functionCARD domain binding
GO_0004175Molecular functionendopeptidase activity
GO_0019900Molecular functionkinase binding
GO_0019955Molecular functioncytokine binding
GO_0008656Molecular functioncysteine-type endopeptidase activator activity involved in apoptotic process
GO_0042802Molecular functionidentical protein binding
GO_0089720Molecular functioncaspase binding
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASP1
Protein nameCASP1 nirs variant 1 (Caspase 1)
Caspase 1 (cDNA FLJ59442, highly similar to Caspase-1)
Caspase 1
Caspase 1 (cDNA FLJ58540, highly similar to Caspase-1)
Caspase-1 (CASP-1) (EC 3.4.22.36) (Interleukin-1 beta convertase) (IL-1BC) (Interleukin-1 beta-converting enzyme) (ICE) (IL-1 beta-converting enzyme) (p45) [Cleaved into: Caspase-1 subunit p20; Caspase-1 subunit p10]
SynonymsIL1BCE
hCG_39362
IL1BC
DescriptionFUNCTION: Thiol protease involved in a variety of inflammatory processes by proteolytically cleaving other proteins, such as the precursors of the inflammatory cytokines interleukin-1 beta (IL1B) and interleukin 18 (IL18) as well as the pyroptosis inducer Gasdermin-D (GSDMD), into active mature peptides . Plays a key role in cell immunity as an inflammatory response initiator: once activated through formation of an inflammasome complex, it initiates a pro-inflammatory response through the cleavage of the two inflammatory cytokines IL1B and IL18, releasing the mature cytokines which are involved in a variety of inflammatory processes . Cleaves a tetrapeptide after an Asp residue at position P1 . Also initiates pyroptosis, a programmed lytic cell death pathway, through cleavage of GSDMD . In contrast to cleavage of interleukin IL1B, recognition and cleavage of GSDMD is not strictly dependent on the consensus cleavage site but depends on an exosite interface on CASP1 that recognizes and binds the Gasdermin-D, C-terminal (GSDMD-CT) part . Cleaves and activates CASP7 in response to bacterial infection, promoting plasma membrane repair . Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of CGAS, rendering it inactive . In apoptotic cells, cleaves SPHK2 which is released from cells and remains enzymatically active extracellularly . .; FUNCTION: [Isoform Delta]: Apoptosis inactive. .; FUNCTION: [Isoform Epsilon]: Apoptosis inactive. .

AccessionsH0YEC7
ENST00000525825.6 [P29466-2]
ENST00000695721.1
ENST00000533400.6 [P29466-1]
ENST00000695716.1
ENST00000526568.5 [P29466-3]
ENST00000532439.6
ENST00000695715.1
ENST00000695718.1
ENST00000695717.1
P29466
B4DVD8
ENST00000534497.5 [P29466-4]
ENST00000695722.1
ENST00000528974.1
A0A8Q3SI00
ENST00000527979.5
ENST00000695720.1
ENST00000436863.7 [P29466-1]
A0A8Q3SIY2
ENST00000529871.1
ENST00000531166.5 [P29466-5]
A0A8Q3SI67
Q5FBZ0
ENST00000695714.1
G3V169
ENST00000695719.1 [P29466-2]
B4DKN4