RBM14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902151Biological processregulation of response to DNA integrity checkpoint signaling
GO_0045087Biological processinnate immune response
GO_0007369Biological processgastrulation
GO_0000398Biological processmRNA splicing, via spliceosome
GO_0009725Biological processresponse to hormone
GO_0046600Biological processnegative regulation of centriole replication
GO_0002218Biological processactivation of innate immune response
GO_0006915Biological processapoptotic process
GO_0098534Biological processcentriole assembly
GO_0045815Biological processtranscription initiation-coupled chromatin remodeling
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005730Cellular componentnucleolus
GO_0016607Cellular componentnuclear speck
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005667Cellular componenttranscription regulator complex
GO_0005634Cellular componentnucleus
GO_0003729Molecular functionmRNA binding
GO_1990935Molecular functionsplicing factor binding
GO_0003723Molecular functionRNA binding
GO_0030374Molecular functionnuclear receptor coactivator activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameRBM14
Protein nameRNA binding motif protein 14 isoform 1
RNA binding motif protein 14 isoform 2
RNA-binding protein 14 (Paraspeckle protein 2) (PSP2) (RNA-binding motif protein 14) (RRM-containing coactivator activator/modulator) (Synaptotagmin-interacting protein) (SYT-interacting protein)
RNA binding motif protein 14 isoform 3
RNA binding motif protein 14
SynonymsSIP
DescriptionFUNCTION: Isoform 1 may function as a nuclear receptor coactivator, enhancing transcription through other coactivators such as NCOA6 and CITED1. Isoform 2, functions as a transcriptional repressor, modulating transcriptional activities of coactivators including isoform 1, NCOA6 and CITED1 . Regulates centriole biogenesis by suppressing the formation of aberrant centriolar protein complexes in the cytoplasm and thus preserving mitotic spindle integrity. Prevents the formation of the STIL-CENPJ complex (which can induce the formation of aberrant centriolar protein complexes) by interfering with the interaction of STIL with CENPJ . Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway . Also involved in the regulation of pre-mRNA alternative splicing . .

AccessionsENST00000310137.5 [Q96PK6-1]
A0A0S2Z4Z0
B8ZZ74
ENST00000393979.3 [Q96PK6-2]
F8WDX3
A0A0S2Z5V2
ENST00000409372.1
ENST00000443702.1
ENST00000409738.4 [Q96PK6-4]
Q96PK6
A0A0S2Z567