Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 6 studies | 32% ± 9% | |
| natural killer cell | 6 studies | 21% ± 3% | |
| endothelial cell | 5 studies | 24% ± 8% | |
| CD8-positive, alpha-beta T cell | 5 studies | 19% ± 3% | |
| CD16-negative, CD56-bright natural killer cell, human | 4 studies | 19% ± 4% | |
| CD4-positive, alpha-beta T cell | 4 studies | 24% ± 3% | |
| epithelial cell | 4 studies | 42% ± 15% | |
| retina horizontal cell | 4 studies | 26% ± 4% | |
| plasmacytoid dendritic cell | 4 studies | 23% ± 6% | |
| conventional dendritic cell | 3 studies | 28% ± 13% | |
| effector memory CD8-positive, alpha-beta T cell | 3 studies | 16% ± 1% | |
| hematopoietic precursor cell | 3 studies | 22% ± 7% | |
| non-classical monocyte | 3 studies | 19% ± 3% | |
| CD16-positive, CD56-dim natural killer cell, human | 3 studies | 18% ± 2% | |
| effector CD8-positive, alpha-beta T cell | 3 studies | 17% ± 3% | |
| macrophage | 3 studies | 21% ± 2% | |
| GABAergic neuron | 3 studies | 37% ± 4% | |
| glutamatergic neuron | 3 studies | 46% ± 8% | |
| dendritic cell | 3 studies | 27% ± 7% | |
| gamma-delta T cell | 3 studies | 29% ± 16% | |
| regulatory T cell | 3 studies | 20% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 100% | 1711.99 | 966 / 966 | 100% | 45.23 | 527 / 527 |
| prostate | 100% | 1215.25 | 245 / 245 | 100% | 34.61 | 502 / 502 |
| stomach | 100% | 1214.40 | 359 / 359 | 100% | 40.11 | 286 / 286 |
| breast | 100% | 1316.41 | 459 / 459 | 100% | 45.20 | 1116 / 1118 |
| kidney | 100% | 1535.08 | 89 / 89 | 100% | 32.25 | 899 / 901 |
| liver | 100% | 1982.96 | 226 / 226 | 100% | 33.87 | 405 / 406 |
| brain | 100% | 1466.48 | 2636 / 2642 | 100% | 29.46 | 703 / 705 |
| esophagus | 100% | 1439.63 | 1445 / 1445 | 99% | 30.85 | 182 / 183 |
| bladder | 100% | 1501.71 | 21 / 21 | 99% | 34.46 | 501 / 504 |
| thymus | 100% | 1342.35 | 653 / 653 | 99% | 31.65 | 601 / 605 |
| adrenal gland | 100% | 1880.52 | 258 / 258 | 99% | 32.39 | 228 / 230 |
| lung | 99% | 1121.87 | 573 / 578 | 100% | 32.98 | 1153 / 1155 |
| ovary | 100% | 1196.93 | 180 / 180 | 99% | 26.57 | 425 / 430 |
| uterus | 100% | 1409.55 | 170 / 170 | 99% | 37.68 | 453 / 459 |
| pancreas | 100% | 921.45 | 327 / 328 | 99% | 31.62 | 176 / 178 |
| skin | 100% | 1510.43 | 1808 / 1809 | 99% | 37.63 | 465 / 472 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 38.71 | 29 / 29 |
| muscle | 100% | 2873.65 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1463.05 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 35.84 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 8.54 | 1 / 1 |
| blood vessel | 100% | 1202.05 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1369.19 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 98% | 1476.80 | 842 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 96% | 25.72 | 77 / 80 |
| peripheral blood | 83% | 1180.75 | 775 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0061077 | Biological process | chaperone-mediated protein folding |
| GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
| GO_0045070 | Biological process | positive regulation of viral genome replication |
| GO_0065003 | Biological process | protein-containing complex assembly |
| GO_0050714 | Biological process | positive regulation of protein secretion |
| GO_0006457 | Biological process | protein folding |
| GO_0034389 | Biological process | lipid droplet organization |
| GO_0019076 | Biological process | viral release from host cell |
| GO_0006915 | Biological process | apoptotic process |
| GO_0015031 | Biological process | protein transport |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0071492 | Biological process | cellular response to UV-A |
| GO_0000413 | Biological process | protein peptidyl-prolyl isomerization |
| GO_0005730 | Cellular component | nucleolus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008134 | Molecular function | transcription factor binding |
| GO_0003755 | Molecular function | peptidyl-prolyl cis-trans isomerase activity |
| GO_0051879 | Molecular function | Hsp90 protein binding |
| GO_0031072 | Molecular function | heat shock protein binding |
| GO_0030331 | Molecular function | nuclear estrogen receptor binding |
| GO_0030544 | Molecular function | Hsp70 protein binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0016018 | Molecular function | cyclosporin A binding |
| Gene name | PPID |
| Protein name | Peptidyl-prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) Peptidylprolyl isomerase D Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (40 kDa peptidyl-prolyl cis-trans isomerase) (Cyclophilin-40) (CYP-40) (Cyclophilin-related protein) (Rotamase D) peptidylprolyl isomerase (EC 5.2.1.8) |
| Synonyms | CYPD CYP40 |
| Description | FUNCTION: PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding . Proposed to act as a co-chaperone in HSP90 complexes such as in unligated steroid receptors heterocomplexes. Different co-chaperones seem to compete for association with HSP90 thus establishing distinct HSP90-co-chaperone-receptor complexes with the potential to exert tissue-specific receptor activity control. May have a preference for estrogen receptor complexes and is not found in glucocorticoid receptor complexes. May be involved in cytoplasmic dynein-dependent movement of the receptor from the cytoplasm to the nucleus. May regulate MYB by inhibiting its DNA-binding activity. Involved in regulation of AHR signaling by promoting the formation of the AHR:ARNT dimer; the function is independent of HSP90 but requires the chaperone activity. Involved in regulation of UV radiation-induced apoptosis. Promotes cell viability in anaplastic lymphoma kinase-positive anaplastic large-cell lymphoma (ALK+ ALCL) cell lines. .; FUNCTION: (Microbial infection) May be involved in hepatitis C virus (HCV) replication and release. . FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. . |
| Accessions | H0Y8J0 Q6FGM6 ENST00000512699.1 Q08752 ENST00000507213.1 H0Y969 ENST00000307720.4 Q05DH6 |