TMEM219 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	31 studies	39% ± 14%	Explore
endothelial cell	31 studies	35% ± 15%	Explore
conventional dendritic cell	27 studies	37% ± 15%	Explore
fibroblast	26 studies	29% ± 11%	Explore
natural killer cell	25 studies	23% ± 7%	Explore
CD4-positive, alpha-beta T cell	25 studies	25% ± 6%	Explore
classical monocyte	24 studies	40% ± 15%	Explore
CD8-positive, alpha-beta T cell	21 studies	24% ± 6%	Explore
B cell	20 studies	24% ± 7%	Explore
non-classical monocyte	20 studies	39% ± 14%	Explore
plasmacytoid dendritic cell	19 studies	34% ± 12%	Explore
epithelial cell	19 studies	39% ± 22%	Explore
pericyte	19 studies	26% ± 9%	Explore
regulatory T cell	19 studies	29% ± 7%	Explore
T cell	18 studies	22% ± 5%	Explore
monocyte	18 studies	35% ± 13%	Explore
basal cell	16 studies	36% ± 18%	Explore
ciliated cell	16 studies	50% ± 15%	Explore
endothelial cell of lymphatic vessel	15 studies	32% ± 10%	Explore
memory B cell	14 studies	23% ± 4%	Explore
mast cell	13 studies	28% ± 6%	Explore
mature NK T cell	13 studies	25% ± 5%	Explore
connective tissue cell	13 studies	29% ± 9%	Explore
naive B cell	13 studies	21% ± 3%	Explore
smooth muscle cell	13 studies	24% ± 8%	Explore
dendritic cell	12 studies	45% ± 24%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	12 studies	27% ± 7%	Explore
capillary endothelial cell	12 studies	30% ± 10%	Explore
gamma-delta T cell	12 studies	28% ± 8%	Explore
CD16-positive, CD56-dim natural killer cell, human	11 studies	25% ± 5%	Explore
vein endothelial cell	11 studies	34% ± 10%	Explore
myeloid cell	11 studies	39% ± 14%	Explore
plasma cell	10 studies	35% ± 9%	Explore
platelet	10 studies	36% ± 11%	Explore
CD8-positive, alpha-beta memory T cell	10 studies	25% ± 9%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	10 studies	29% ± 5%	Explore
myofibroblast cell	10 studies	25% ± 9%	Explore
endothelial cell of artery	10 studies	33% ± 10%	Explore
CD4-positive, alpha-beta memory T cell	9 studies	29% ± 8%	Explore
secretory cell	9 studies	40% ± 14%	Explore
CD16-negative, CD56-bright natural killer cell, human	9 studies	26% ± 4%	Explore
mucosal invariant T cell	9 studies	25% ± 4%	Explore
endothelial cell of vascular tree	9 studies	33% ± 8%	Explore
type I pneumocyte	8 studies	29% ± 12%	Explore
progenitor cell	8 studies	27% ± 11%	Explore
goblet cell	8 studies	34% ± 13%	Explore
abnormal cell	8 studies	39% ± 19%	Explore
plasmablast	7 studies	33% ± 17%	Explore
effector memory CD8-positive, alpha-beta T cell	7 studies	27% ± 8%	Explore
enterocyte	7 studies	37% ± 15%	Explore
mesothelial cell	7 studies	35% ± 18%	Explore
T follicular helper cell	7 studies	28% ± 4%	Explore
alveolar macrophage	6 studies	36% ± 12%	Explore
club cell	6 studies	41% ± 7%	Explore
respiratory goblet cell	6 studies	39% ± 20%	Explore
epithelial cell of proximal tubule	6 studies	31% ± 8%	Explore
kidney loop of Henle epithelial cell	6 studies	27% ± 11%	Explore
renal alpha-intercalated cell	6 studies	37% ± 10%	Explore
astrocyte	6 studies	22% ± 9%	Explore
mononuclear phagocyte	5 studies	38% ± 17%	Explore
enteroendocrine cell	5 studies	35% ± 13%	Explore
leukocyte	5 studies	28% ± 8%	Explore
hematopoietic stem cell	5 studies	39% ± 8%	Explore
type II pneumocyte	5 studies	42% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	24% ± 5%	Explore
hematopoietic precursor cell	4 studies	42% ± 14%	Explore
pancreatic A cell	4 studies	48% ± 12%	Explore
type B pancreatic cell	4 studies	47% ± 15%	Explore
exhausted T cell	4 studies	35% ± 8%	Explore
glomerular endothelial cell	4 studies	33% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	4 studies	31% ± 9%	Explore
transit amplifying cell	4 studies	26% ± 11%	Explore
megakaryocyte	4 studies	47% ± 3%	Explore
innate lymphoid cell	4 studies	23% ± 2%	Explore
microglial cell	4 studies	30% ± 13%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	37% ± 10%	Explore
intermediate monocyte	4 studies	55% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	45% ± 14%	Explore
neuron	4 studies	31% ± 15%	Explore
luminal cell of prostate epithelium	4 studies	27% ± 11%	Explore
effector memory CD4-positive, alpha-beta T cell	4 studies	36% ± 9%	Explore
neutrophil	4 studies	18% ± 2%	Explore
brush cell	4 studies	21% ± 3%	Explore
T-helper 17 cell	4 studies	23% ± 2%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	24% ± 4%	Explore
deuterosomal cell	3 studies	26% ± 12%	Explore
duct epithelial cell	3 studies	41% ± 15%	Explore
ionocyte	3 studies	33% ± 7%	Explore
squamous epithelial cell	3 studies	39% ± 26%	Explore
podocyte	3 studies	35% ± 5%	Explore
intestinal crypt stem cell	3 studies	36% ± 6%	Explore
IgG plasma cell	3 studies	19% ± 3%	Explore
common myeloid progenitor	3 studies	42% ± 23%	Explore
lymphocyte	3 studies	30% ± 8%	Explore
pro-B cell	3 studies	20% ± 3%	Explore
neuroendocrine cell	3 studies	33% ± 10%	Explore
retinal cone cell	3 studies	43% ± 17%	Explore
serous secreting cell	3 studies	52% ± 20%	Explore
intraepithelial lymphocyte	3 studies	24% ± 5%	Explore
oligodendrocyte	3 studies	25% ± 9%	Explore
inflammatory macrophage	3 studies	27% ± 7%	Explore
glutamatergic neuron	3 studies	29% ± 10%	Explore
pancreatic ductal cell	3 studies	44% ± 8%	Explore
oligodendrocyte precursor cell	3 studies	23% ± 7%	Explore
granulocyte	3 studies	33% ± 9%	Explore
granulocyte monocyte progenitor cell	3 studies	25% ± 6%	Explore
glial cell	3 studies	29% ± 12%	Explore
hepatocyte	3 studies	41% ± 30%	Explore
group 3 innate lymphoid cell	3 studies	27% ± 11%	Explore
T-helper 1 cell	3 studies	27% ± 6%	Explore
double negative thymocyte	3 studies	32% ± 5%	Explore
progenitor cell of mammary luminal epithelium	3 studies	36% ± 10%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	16 studies	34% ± 13%	Explore
peripheral blood	16 studies	33% ± 9%	Explore
intestine	10 studies	27% ± 13%	Explore
kidney	8 studies	29% ± 9%	Explore
brain	6 studies	26% ± 8%	Explore
pancreas	4 studies	44% ± 16%	Explore
uterus	4 studies	36% ± 15%	Explore
lymph node	4 studies	33% ± 22%	Explore
breast	4 studies	31% ± 9%	Explore
liver	4 studies	25% ± 6%	Explore
bone marrow	3 studies	24% ± 7%	Explore
adrenal gland	3 studies	21% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
adrenal gland	100%	6974.69	258 / 258	100%	152.93	230 / 230
brain	100%	5321.41	2642 / 2642	100%	138.41	705 / 705
esophagus	100%	4235.93	1445 / 1445	100%	70.30	183 / 183
kidney	100%	6265.69	89 / 89	100%	160.42	901 / 901
liver	100%	3956.44	226 / 226	100%	125.36	406 / 406
lung	100%	5440.93	578 / 578	100%	122.35	1155 / 1155
ovary	100%	4230.48	180 / 180	100%	136.77	430 / 430
pancreas	100%	3571.18	328 / 328	100%	170.59	178 / 178
skin	100%	4437.40	1809 / 1809	100%	143.30	472 / 472
thymus	100%	5119.72	653 / 653	100%	180.33	605 / 605
uterus	100%	4201.34	170 / 170	100%	140.73	459 / 459
prostate	100%	6091.68	245 / 245	100%	177.89	501 / 502
stomach	100%	5257.03	359 / 359	100%	108.88	285 / 286
intestine	100%	5157.39	966 / 966	100%	130.63	525 / 527
bladder	100%	4609.71	21 / 21	100%	156.50	502 / 504
breast	100%	5089.56	459 / 459	99%	182.34	1111 / 1118
adipose	100%	4970.75	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	206.86	80 / 80
lymph node	0%	0	0 / 0	100%	149.78	29 / 29
spleen	100%	5800.56	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	94.41	45 / 45
ureter	0%	0	0 / 0	100%	134.73	1 / 1
blood vessel	100%	4548.67	1334 / 1335	0%	0	0 / 0
heart	100%	3102.05	860 / 861	0%	0	0 / 0
muscle	99%	2278.39	791 / 803	0%	0	0 / 0
peripheral blood	97%	2565.96	899 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0006915	Biological process	apoptotic process
GO_0005886	Cellular component	plasma membrane
GO_0005515	Molecular function	protein binding

Gene name	TMEM219
Protein name	Transmembrane protein 219 Insulin-like growth factor-binding protein 3 receptor (IGFBP-3R) (Transmembrane protein 219)
Synonyms
Description	FUNCTION: Cell death receptor specific for IGFBP3, may mediate caspase-8-dependent apoptosis upon ligand binding. .
Accessions	Q86XT9 ENST00000414689.6 H3BML8 ENST00000279396.11 ENST00000575829.6 ENST00000569445.2 ENST00000561899.6 ENST00000566848.5 I3L2J7 ENST00000570255.6 ENST00000569481.1 I3L4B3

TMEM219 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review