FXR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0099577Biological processregulation of translation at presynapse, modulating synaptic transmission
GO_0140694Biological processnon-membrane-bounded organelle assembly
GO_0051664Biological processnuclear pore localization
GO_0048170Biological processpositive regulation of long-term neuronal synaptic plasticity
GO_0043488Biological processregulation of mRNA stability
GO_0051028Biological processmRNA transport
GO_0021542Biological processdentate gyrus development
GO_0061157Biological processmRNA destabilization
GO_0051292Biological processnuclear pore complex assembly
GO_0051966Biological processregulation of synaptic transmission, glutamatergic
GO_0048513Biological processanimal organ development
GO_0050728Biological processnegative regulation of inflammatory response
GO_0007517Biological processmuscle organ development
GO_0045727Biological processpositive regulation of translation
GO_0006915Biological processapoptotic process
GO_0045187Biological processregulation of circadian sleep/wake cycle, sleep
GO_1900272Biological processnegative regulation of long-term synaptic potentiation
GO_0060538Biological processskeletal muscle organ development
GO_0050767Biological processregulation of neurogenesis
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_1902373Biological processnegative regulation of mRNA catabolic process
GO_0007286Biological processspermatid development
GO_0017148Biological processnegative regulation of translation
GO_2000637Biological processpositive regulation of miRNA-mediated gene silencing
GO_0005730Cellular componentnucleolus
GO_0098978Cellular componentglutamatergic synapse
GO_0098793Cellular componentpresynapse
GO_0043197Cellular componentdendritic spine
GO_0005840Cellular componentribosome
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0043034Cellular componentcostamere
GO_0036464Cellular componentcytoplasmic ribonucleoprotein granule
GO_0005635Cellular componentnuclear envelope
GO_0043005Cellular componentneuron projection
GO_0005829Cellular componentcytosol
GO_0043232Cellular componentintracellular non-membrane-bounded organelle
GO_0005737Cellular componentcytoplasm
GO_0030424Cellular componentaxon
GO_0010494Cellular componentcytoplasmic stress granule
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0045182Molecular functiontranslation regulator activity
GO_0140693Molecular functionmolecular condensate scaffold activity
GO_0033592Molecular functionRNA strand annealing activity
GO_0035925Molecular functionmRNA 3'-UTR AU-rich region binding
GO_0003723Molecular functionRNA binding
GO_0046982Molecular functionprotein heterodimerization activity
GO_0003730Molecular functionmRNA 3'-UTR binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameFXR1
Protein nameFMR1 autosomal homolog 1
RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)
FXR1 protein
Fragile X mental retardation autosomal homolog variant p1K
FMR1 autosomal homolog 1 (cDNA FLJ58644, highly similar to Fragile X mental retardation syndrome-related protein 1)
RNA-binding protein FXR1
SynonymshCG_2021334
DescriptionFUNCTION: mRNA-binding protein that acts as a regulator of mRNAs translation and/or stability, and which is required for various processes, such as neurogenesis, muscle development and spermatogenesis . Specifically binds to AU-rich elements (AREs) in the 3'-UTR of target mRNAs . Promotes formation of some phase-separated membraneless compartment by undergoing liquid-liquid phase separation upon binding to AREs-containing mRNAs, leading to assemble mRNAs into cytoplasmic ribonucleoprotein granules that concentrate mRNAs with associated regulatory factors (By similarity). Required to activate translation of stored mRNAs during late spermatogenesis: acts by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules that recruit translation initiation factor EIF4G3 to activate translation of stored mRNAs in late spermatids (By similarity). Promotes translation of MYC transcripts by recruiting the eIF4F complex to the translation start site . Acts as a negative regulator of inflammation in response to IL19 by promoting destabilization of pro-inflammatory transcripts . Also acts as an inhibitor of inflammation by binding to TNF mRNA, decreasing TNF protein production (By similarity). Acts as a negative regulator of AMPA receptor GRIA2/GluA2 synthesis during long-lasting synaptic potentiation of hippocampal neurons by binding to GRIA2/GluA2 mRNA, thereby inhibiting its translation (By similarity). Regulates proliferation of adult neural stem cells by binding to CDKN1A mRNA and promoting its expression (By similarity). Acts as a regulator of sleep and synaptic homeostasis by regulating translation of transcripts in neurons (By similarity). Required for embryonic and postnatal development of muscle tissue by undergoing liquid-liquid phase separation to assemble target mRNAs into cytoplasmic ribonucleoprotein granules . Involved in the nuclear pore complex localization to the nuclear envelope by preventing cytoplasmic aggregation of nucleoporins: acts by preventing ectopic phase separation of nucleoporins in the cytoplasm via a microtubule-dependent mechanism . .

AccessionsENST00000484790.5
Q14341
E9PFF5
C9JZE0
ENST00000480918.5
C9JAJ4
B4DXZ6
C9J5B4
A0A0F7L1S3
ENST00000445140.6 [P51114-2]
C9JYQ6
ENST00000305586.11 [P51114-3]
P51114
ENST00000469882.5
A0A8V8TMQ1
ENST00000357559.9 [P51114-1]
ENST00000468861.5
A0A8V8TNP6
ENST00000491674.1
A0A0F7KYT8
C9IZ22
ENST00000491062.5
ENST00000465551.5
A0A8V8TM97
ENST00000484042.1
H7C4S4
ENST00000484958.5
ENST00000475315.5
C9JY20
A0A0F7L0Q8
ENST00000698794.1
A0A0F7L2Z7
ENST00000698793.1
ENST00000482125.1
E7EU85