SLC25A6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_1990544Biological processmitochondrial ATP transmembrane transport
GO_1901029Biological processnegative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
GO_0140021Biological processmitochondrial ADP transmembrane transport
GO_0005744Cellular componentTIM23 mitochondrial import inner membrane translocase complex
GO_0016020Cellular componentmembrane
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0005471Molecular functionATP:ADP antiporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC25A6
Protein nameADP/ATP translocase 3 (ADP,ATP carrier protein 3) (ADP,ATP carrier protein, isoform T2) (ANT 2) (Adenine nucleotide translocator 3) (ANT 3) (Solute carrier family 25 member 6) [Cleaved into: ADP/ATP translocase 3, N-terminally processed]
ADP/ATP translocase (ADP,ATP carrier protein)
SynonymshCG_1746794
CDABP0051
ANT3
AAC3
DescriptionFUNCTION: ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell (By similarity). Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane (By similarity). In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity . Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis (By similarity). Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A6/ANT3 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity) (By similarity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it (By similarity). Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death . It is however unclear if SLC25A6/ANT3 constitutes a pore-forming component of mPTP or regulates it (By similarity). .

FUNCTION: Catalyzes the exchange of ADP and ATP across the membrane. .

AccessionsP12236
Q6I9V5
ENST00000711214.1
ENST00000381401.11