CASP7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007507Biological processheart development
GO_0016485Biological processprotein processing
GO_0009411Biological processresponse to UV
GO_0051146Biological processstriated muscle cell differentiation
GO_0043525Biological processpositive regulation of neuron apoptotic process
GO_0051402Biological processneuron apoptotic process
GO_0072734Biological processcellular response to staurosporine
GO_0006508Biological processproteolysis
GO_1905686Biological processpositive regulation of plasma membrane repair
GO_0030163Biological processprotein catabolic process
GO_0042742Biological processdefense response to bacterium
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0097194Biological processexecution phase of apoptosis
GO_0006915Biological processapoptotic process
GO_0044346Biological processfibroblast apoptotic process
GO_0051604Biological processprotein maturation
GO_0070227Biological processlymphocyte apoptotic process
GO_0005615Cellular componentextracellular space
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0008233Molecular functionpeptidase activity
GO_0097153Molecular functioncysteine-type endopeptidase activity involved in apoptotic process
GO_0097200Molecular functioncysteine-type endopeptidase activity involved in execution phase of apoptosis
GO_0003723Molecular functionRNA binding
GO_0004190Molecular functionaspartic-type endopeptidase activity
GO_0008234Molecular functioncysteine-type peptidase activity
GO_0004197Molecular functioncysteine-type endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCASP7
Protein nameCaspase-7 (CASP-7) (EC 3.4.22.60) (Apoptotic protease Mch-3) (CMH-1) (ICE-like apoptotic protease 3) (ICE-LAP3) [Cleaved into: Caspase-7 subunit p20; Caspase-7 subunit p11]
Caspase 7
SynonymsMCH3
DescriptionFUNCTION: Thiol protease involved in different programmed cell death processes, such as apoptosis, pyroptosis or granzyme-mediated programmed cell death, by proteolytically cleaving target proteins . Has a marked preference for Asp-Glu-Val-Asp (DEVD) consensus sequences, with some plasticity for alternate non-canonical sequences . Its involvement in the different programmed cell death processes is probably determined by upstream proteases that activate CASP7 (By similarity). Acts as an effector caspase involved in the execution phase of apoptosis: following cleavage and activation by initiator caspases (CASP8, CASP9 and/or CASP10), mediates execution of apoptosis by catalyzing cleavage of proteins, such as CLSPN, PARP1, PTGES3 and YY1 . Compared to CASP3, acts as a minor executioner caspase and cleaves a limited set of target proteins . Acts as a key regulator of the inflammatory response in response to bacterial infection by catalyzing cleavage and activation of the sphingomyelin phosphodiesterase SMPD1 in the extracellular milieu, thereby promoting membrane repair . Regulates pyroptosis in intestinal epithelial cells: cleaved and activated by CASP1 in response to S.typhimurium infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of gasdermin-D (GSDMD) pores (By similarity). Regulates granzyme-mediated programmed cell death in hepatocytes: cleaved and activated by granzyme B (GZMB) in response to bacterial infection, promoting its secretion to the extracellular milieu, where it catalyzes activation of SMPD1, generating ceramides that repair membranes and counteract the action of perforin (PRF1) pores (By similarity). Following cleavage by CASP1 in response to inflammasome activation, catalyzes processing and inactivation of PARP1, alleviating the transcription repressor activity of PARP1 . Acts as an inhibitor of type I interferon production during virus-induced apoptosis by mediating cleavage of antiviral proteins CGAS, IRF3 and MAVS, thereby preventing cytokine overproduction (By similarity). Cleaves and activates sterol regulatory element binding proteins (SREBPs) . Cleaves phospholipid scramblase proteins XKR4, XKR8 and XKR9 (By similarity). In case of infection, catalyzes cleavage of Kaposi sarcoma-associated herpesvirus protein ORF57, thereby preventing expression of viral lytic genes . .; FUNCTION: [Isoform Beta]: Lacks enzymatic activity. .

AccessionsENST00000621345.4 [P55210-1]
ENST00000672138.1
A0A0A0MRL7
ENST00000429617.5
ENST00000369331.8 [P55210-2]
A0A5F9ZHZ6
ENST00000369321.6
ENST00000345633.8 [P55210-1]
Q5SVL2
ENST00000614447.4 [P55210-2]
ENST00000369315.5 [P55210-1]
ENST00000369318.8 [P55210-1]
P55210
ENST00000621607.4 [P55210-3]
ENST00000452490.3 [P55210-4]