UXT report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0047497Biological processmitochondrion transport along microtubule
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0007098Biological processcentrosome cycle
GO_0050821Biological processprotein stabilization
GO_0000226Biological processmicrotubule cytoskeleton organization
GO_0006915Biological processapoptotic process
GO_0005856Cellular componentcytoskeleton
GO_1990062Cellular componentRPAP3/R2TP/prefoldin-like complex
GO_0000922Cellular componentspindle pole
GO_0005813Cellular componentcentrosome
GO_0005654Cellular componentnucleoplasm
GO_0101031Cellular componentprotein folding chaperone complex
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0048487Molecular functionbeta-tubulin binding
GO_0003682Molecular functionchromatin binding
GO_0051015Molecular functionactin filament binding
GO_0003714Molecular functiontranscription corepressor activity
GO_0008017Molecular functionmicrotubule binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUXT
Protein nameProtein UXT (Androgen receptor trapped clone 27 protein) (ART-27) (Ubiquitously expressed transcript protein)
Ubiquitously expressed prefoldin like chaperone
SynonymsHSPC024
DescriptionFUNCTION: Involved in gene transcription regulation . Acts in concert with the corepressor URI1 to regulate androgen receptor AR-mediated transcription . Together with URI1, associates with chromatin to the NKX3-1 promoter region . Negatively regulates the transcriptional activity of the estrogen receptor ESR1 by inducing its translocation into the cytoplasm . May act as nuclear chaperone that facilitates the formation of the NF-kappa-B enhanceosome and thus positively regulates NF-kappa-B transcription activity . Potential component of mitochondrial-associated LRPPRC, a multidomain organizer that potentially integrates mitochondria and the microtubular cytoskeleton with chromosome remodeling . Increasing concentrations of UXT contributes to progressive aggregation of mitochondria and cell death potentially through its association with LRPPRC . Suppresses cell transformation and it might mediate this function by interaction and inhibition of the biological activity of cell proliferation and survival stimulatory factors like MECOM . .; FUNCTION: [Isoform 1]: Plays a role in protecting cells against TNF-alpha-induced apoptosis by preventing the recruitment of FADD and caspase 8 to the apoptotic complex I, composed of TRADD, TRAF2 and RIPK1/RIP. .

AccessionsQ9UBK9
ENST00000485641.5
ENST00000333119.8 [Q9UBK9-1]
S4R2Z4
ENST00000335890.3 [Q9UBK9-2]