TRIAP1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0043154Biological processnegative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0097035Biological processregulation of membrane lipid distribution
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0015914Biological processphospholipid transport
GO_0034644Biological processcellular response to UV
GO_0090201Biological processnegative regulation of release of cytochrome c from mitochondria
GO_0120009Biological processintermembrane lipid transfer
GO_2001140Biological processpositive regulation of phospholipid transport
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045332Biological processphospholipid translocation
GO_1902166Biological processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006977Biological processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO_0006915Biological processapoptotic process
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0005739Cellular componentmitochondrion
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0032991Cellular componentprotein-containing complex
GO_0005654Cellular componentnucleoplasm
GO_0005634Cellular componentnucleus
GO_0002039Molecular functionp53 binding
GO_1990050Molecular functionphosphatidic acid transfer activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRIAP1
Protein nameTP53-regulated inhibitor of apoptosis 1 (Protein 15E1.1) (WF-1) (p53-inducible cell-survival factor) (p53CSV)
Synonyms15E1.1
HSPC132
DescriptionFUNCTION: Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane . Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) . Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis . .

AccessionsENST00000546954.2
O43715