TNFSF10 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	31 studies	46% ± 20%	Explore
non-classical monocyte	22 studies	40% ± 18%	Explore
classical monocyte	21 studies	32% ± 14%	Explore
mast cell	19 studies	41% ± 19%	Explore
basal cell	16 studies	38% ± 17%	Explore
capillary endothelial cell	16 studies	44% ± 19%	Explore
endothelial cell of lymphatic vessel	15 studies	31% ± 11%	Explore
epithelial cell	14 studies	30% ± 14%	Explore
monocyte	14 studies	28% ± 8%	Explore
endothelial cell of artery	13 studies	49% ± 23%	Explore
vein endothelial cell	13 studies	41% ± 17%	Explore
endothelial cell of vascular tree	11 studies	35% ± 15%	Explore
fibroblast	11 studies	26% ± 7%	Explore
ciliated cell	10 studies	34% ± 13%	Explore
natural killer cell	10 studies	20% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	10 studies	24% ± 8%	Explore
secretory cell	9 studies	41% ± 18%	Explore
club cell	8 studies	48% ± 16%	Explore
conventional dendritic cell	8 studies	27% ± 14%	Explore
respiratory goblet cell	7 studies	58% ± 14%	Explore
CD4-positive, alpha-beta T cell	7 studies	24% ± 6%	Explore
epithelial cell of proximal tubule	7 studies	30% ± 8%	Explore
enterocyte	7 studies	27% ± 7%	Explore
goblet cell	7 studies	30% ± 11%	Explore
neutrophil	6 studies	19% ± 2%	Explore
macrophage	6 studies	24% ± 4%	Explore
regulatory T cell	6 studies	20% ± 5%	Explore
innate lymphoid cell	6 studies	20% ± 4%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	5 studies	22% ± 5%	Explore
myeloid cell	5 studies	21% ± 5%	Explore
brush cell	5 studies	25% ± 9%	Explore
CD4-positive, alpha-beta memory T cell	5 studies	20% ± 3%	Explore
type II pneumocyte	4 studies	23% ± 4%	Explore
deuterosomal cell	4 studies	35% ± 8%	Explore
duct epithelial cell	4 studies	34% ± 16%	Explore
squamous epithelial cell	4 studies	30% ± 19%	Explore
effector CD8-positive, alpha-beta T cell	4 studies	29% ± 8%	Explore
glomerular endothelial cell	4 studies	56% ± 6%	Explore
abnormal cell	4 studies	33% ± 7%	Explore
CD8-positive, alpha-beta T cell	4 studies	32% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	34% ± 19%	Explore
dendritic cell	4 studies	29% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	3 studies	24% ± 8%	Explore
exhausted T cell	3 studies	27% ± 3%	Explore
hematopoietic precursor cell	3 studies	31% ± 13%	Explore
extravillous trophoblast	3 studies	32% ± 3%	Explore
T cell	3 studies	27% ± 2%	Explore
mucus secreting cell	3 studies	41% ± 12%	Explore
serous secreting cell	3 studies	28% ± 15%	Explore
kidney loop of Henle epithelial cell	3 studies	18% ± 2%	Explore
effector CD4-positive, alpha-beta T cell	3 studies	30% ± 4%	Explore
type I pneumocyte	3 studies	24% ± 5%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	23% ± 1%	Explore
pancreatic ductal cell	3 studies	54% ± 13%	Explore
T follicular helper cell	3 studies	19% ± 1%	Explore
microglial cell	3 studies	16% ± 0%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	11 studies	21% ± 4%	Explore
lung	10 studies	31% ± 15%	Explore
kidney	6 studies	21% ± 3%	Explore
intestine	6 studies	23% ± 8%	Explore
uterus	3 studies	23% ± 6%	Explore
prostate	3 studies	17% ± 1%	Explore
liver	3 studies	18% ± 1%	Explore
breast	3 studies	23% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
prostate	98%	5441.93	239 / 245	99%	229.65	495 / 502
breast	99%	5689.00	456 / 459	93%	226.39	1037 / 1118
kidney	100%	7253.30	89 / 89	89%	293.30	803 / 901
lung	100%	10005.46	578 / 578	89%	198.95	1025 / 1155
esophagus	97%	3148.90	1404 / 1445	87%	134.83	159 / 183
uterus	94%	1963.73	159 / 170	83%	353.44	380 / 459
intestine	95%	2979.63	920 / 966	80%	62.51	424 / 527
bladder	95%	2402.29	20 / 21	77%	127.60	388 / 504
stomach	92%	1646.09	330 / 359	80%	65.91	228 / 286
ovary	91%	1950.79	164 / 180	80%	131.19	344 / 430
pancreas	82%	1096.22	270 / 328	88%	97.27	157 / 178
liver	90%	2918.37	204 / 226	74%	85.31	300 / 406
thymus	98%	2862.18	643 / 653	15%	9.09	89 / 605
adrenal gland	91%	4511.65	234 / 258	12%	8.06	27 / 230
spleen	100%	4052.98	241 / 241	0%	0	0 / 0
adipose	99%	4600.24	1197 / 1204	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	339.24	44 / 45
skin	76%	1923.21	1367 / 1809	20%	13.31	93 / 472
peripheral blood	84%	6027.99	785 / 929	0%	0	0 / 0
heart	76%	1035.49	655 / 861	0%	0	0 / 0
lymph node	0%	0	0 / 0	72%	64.72	21 / 29
blood vessel	58%	865.68	772 / 1335	0%	0	0 / 0
muscle	47%	501.94	377 / 803	0%	0	0 / 0
brain	23%	258.68	598 / 2642	4%	2.24	28 / 705
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0090200	Biological process	positive regulation of release of cytochrome c from mitochondria
GO_2001238	Biological process	positive regulation of extrinsic apoptotic signaling pathway
GO_0007165	Biological process	signal transduction
GO_0032868	Biological process	response to insulin
GO_0043280	Biological process	positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0007267	Biological process	cell-cell signaling
GO_0006955	Biological process	immune response
GO_0043123	Biological process	positive regulation of canonical NF-kappaB signal transduction
GO_0008584	Biological process	male gonad development
GO_0006915	Biological process	apoptotic process
GO_0043065	Biological process	positive regulation of apoptotic process
GO_0005576	Cellular component	extracellular region
GO_0005886	Cellular component	plasma membrane
GO_0070062	Cellular component	extracellular exosome
GO_0045569	Molecular function	TRAIL binding
GO_0042802	Molecular function	identical protein binding
GO_0005102	Molecular function	signaling receptor binding
GO_0008270	Molecular function	zinc ion binding
GO_0005164	Molecular function	tumor necrosis factor receptor binding
GO_0005515	Molecular function	protein binding
GO_0005125	Molecular function	cytokine activity

IV. Literature review

[source]

Gene name	TNFSF10
Protein name	TNF superfamily member 10 Chemokine tumor necrosis factor ligand superfamily member 10 Tumor necrosis factor ligand superfamily member 10 (Apo-2 ligand) (Apo-2L) (TNF-related apoptosis-inducing ligand) (Protein TRAIL) (CD antigen CD253) Tumor necrosis factor ligand superfamily member
Synonyms	hCG_20249 APO2L TRAIL
Description	FUNCTION: Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG . Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. .
Accessions	Q6IBA9 Q6JSD9 ENST00000241261.7 [P50591-1] ENST00000430881.1 ENST00000420541.6 [P50591-2] P50591 H7C246

TNFSF10 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review