BAG6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006325Biological processchromatin organization
GO_0070059Biological processintrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO_0030324Biological processlung development
GO_0007130Biological processsynaptonemal complex assembly
GO_0007283Biological processspermatogenesis
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0045995Biological processregulation of embryonic development
GO_0010498Biological processproteasomal protein catabolic process
GO_0030101Biological processnatural killer cell activation
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0036506Biological processmaintenance of unfolded protein
GO_0018393Biological processinternal peptidyl-lysine acetylation
GO_0001822Biological processkidney development
GO_0042771Biological processintrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO_0006620Biological processpost-translational protein targeting to endoplasmic reticulum membrane
GO_0061857Biological processendoplasmic reticulum stress-induced pre-emptive quality control
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045861Biological processnegative regulation of proteolysis
GO_0030154Biological processcell differentiation
GO_0050821Biological processprotein stabilization
GO_0007420Biological processbrain development
GO_0006915Biological processapoptotic process
GO_1904294Biological processpositive regulation of ERAD pathway
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0031647Biological processregulation of protein stability
GO_0002429Biological processimmune response-activating cell surface receptor signaling pathway
GO_0016020Cellular componentmembrane
GO_0071818Cellular componentBAT3 complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0051787Molecular functionmisfolded protein binding
GO_0070628Molecular functionproteasome binding
GO_0060090Molecular functionmolecular adaptor activity
GO_0043022Molecular functionribosome binding
GO_0005102Molecular functionsignaling receptor binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0030544Molecular functionHsp70 protein binding
GO_0031593Molecular functionpolyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_1990381Molecular functionubiquitin-specific protease binding

IV. Literature review

[source]
Gene nameBAG6
Protein nameLarge proline-rich protein BAG6
Large proline-rich protein BAG6 (BCL2-associated athanogene 6) (HLA-B-associated transcript 3)
BAG cochaperone 6
BAG cochaperone 6 (Large proline-rich protein BAG6)
Large proline-rich protein BAG6 (BAG family molecular chaperone regulator 6) (BCL2-associated athanogene 6) (BAG-6) (HLA-B-associated transcript 3) (Protein G3) (Protein Scythe)
SynonymshCG_2005629
G3
BAT3
DescriptionFUNCTION: ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins . Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation . The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum . Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome . SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins . Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum . The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome . BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response (By similarity). BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress . By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis (By similarity). Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1 (By similarity). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway . .; FUNCTION: Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity . When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2) . .; FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .; FUNCTION: Mediates ricin-induced apoptosis. .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

FUNCTION: Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC). .

AccessionsENST00000615224.2 [P46379-4]
ENST00000415721.5
A0A7I2V3H1
ENST00000447798.5
ENST00000419847.5 [P46379-2]
ENST00000676571.1
ENST00000425568.5
ENST00000445869.5
H0Y4L1
ENST00000449450.6 [P46379-1]
ENST00000375964.11
ENST00000438112.5
ENST00000453241.5
ENST00000442479.6 [P46379-2]
ENST00000429830.5
ENST00000613474.4 [P46379-4]
ENST00000425649.6
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ENST00000439917.5
A0A0G2JL47
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ENST00000454165.1
ENST00000417144.5 [P46379-2]
ENST00000438641.5
ENST00000424480.5
ENST00000449874.5
ENST00000551350.5 [P46379-5]
ENST00000615725.4 [P46379-4]
ENST00000422756.6
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ENST00000433146.5
ENST00000617635.2 [P46379-4]
ENST00000453036.5
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F6TC96
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F6X9W3
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ENST00000679119.1
ENST00000436807.5
ENST00000456622.5
ENST00000383448.6 [P46379-2]
ENST00000426331.5
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X6REW1
F6XTU0
H0Y7K4
ENST00000434446.5
ENST00000458287.5
ENST00000615143.1 [P46379-4]
ENST00000432539.5
F6VEM6
H0Y710
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A0A0G2JIB3
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H0Y759
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ENST00000417824.5
ENST00000420098.5
ENST00000621056.2 [P46379-4]
ENST00000431989.5
ENST00000458596.5
ENST00000362049.10 [P46379-5]
ENST00000552605.4 [P46379-5]
ENST00000418840.5
ENST00000451534.5
ENST00000451932.6 [P46379-1]
ENST00000436814.5
ENST00000415373.6
ENST00000424176.5
P46379
ENST00000361076.9 [P46379-1]
ENST00000441994.5
ENST00000438546.5
ENST00000421106.5
ENST00000676615.2 [P46379-3]
ENST00000419635.5
ENST00000436434.5
ENST00000420942.5
ENST00000428271.5
ENST00000412012.5
ENST00000423612.5
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A0A1B0GX79
ENST00000437735.5
A0A7P0MQS5
A0A024RCM4
ENST00000435066.5
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ENST00000457802.5
ENST00000424504.5
ENST00000451042.5
ENST00000411914.5
A0A0G2JK23
ENST00000383446.8 [P46379-2]
ENST00000449173.5
ENST00000456223.5
ENST00000456286.5
ENST00000430999.5
ENST00000211379.9 [P46379-2]
ENST00000414208.5
ENST00000412992.5
ENST00000421991.5
ENST00000416797.5
ENST00000455409.5
ENST00000453763.5
ENST00000435080.5
F6U1F2
ENST00000435543.5
ENST00000454478.6
ENST00000441898.5
ENST00000443182.6 [P46379-2]
ENST00000452627.5
ENST00000434874.5
ENST00000415770.5
ENST00000444557.5
F6S6P2
ENST00000448278.5
ENST00000438149.5
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F6U341
ENST00000451898.5
ENST00000427244.5
ENST00000436569.5
ENST00000427281.5
ENST00000442427.5
ENST00000451948.5
ENST00000445519.5
ENST00000375976.8 [P46379-2]
ENST00000437054.5
ENST00000455689.5
ENST00000437771.5
A0A0G2JIA9
ENST00000415345.5
ENST00000428326.5
ENST00000552116.2 [P46379-5]
ENST00000422948.5
ENST00000439687.6 [P46379-4]
ENST00000441054.5
A0A0G2JJM1
ENST00000446133.5
ENST00000423989.5
A0A0G2JJR8
ENST00000416094.5
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F6WML8
F6UR09
ENST00000550393.4
ENST00000438330.5