Biological process

SRP-independent endoplasmic reticulum protein-membrane targeting, posttranslational endoplasmic reticulum membrane targeting, posttranslational endoplasmic reticulum protein-membrane targeting, posttranslational protein endoplasmic reticulum membrane targeting, posttranslational protein targeting to ER membrane, posttranslational protein targeting to endoplasmic reticulum membrane

The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane.