UBL4A report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of UBL4A at tissue level.

III. Associated gene sets

GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0006620Biological processpost-translational protein targeting to endoplasmic reticulum membrane
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0036211Biological processprotein modification process
GO_0031647Biological processregulation of protein stability
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0071818Cellular componentBAT3 complex
GO_0016020Cellular componentmembrane
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0019787Molecular functionubiquitin-like protein transferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameUBL4A
Protein nameUbiquitin-like protein 4A
Ubiquitin like 4A
Ubiquitin-like protein 4A (Ubiquitin-like protein GDX)
SynonymsGDX
UBL4
DXS254E
DescriptionFUNCTION: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation . The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum . Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome . Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum . The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome . .

AccessionsF8WB70
ENST00000369653.8
ENST00000417913.1
P11441
F8WCT8
Q5HY81
ENST00000369660.9
ENST00000630530.1