SEC63 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
fibroblast	38 studies	27% ± 12%	Explore
endothelial cell	27 studies	28% ± 13%	Explore
smooth muscle cell	23 studies	20% ± 4%	Explore
pericyte	20 studies	22% ± 6%	Explore
ciliated cell	15 studies	30% ± 11%	Explore
endothelial cell of lymphatic vessel	14 studies	22% ± 7%	Explore
myofibroblast cell	14 studies	23% ± 6%	Explore
connective tissue cell	14 studies	26% ± 7%	Explore
macrophage	14 studies	26% ± 10%	Explore
natural killer cell	13 studies	18% ± 2%	Explore
plasma cell	13 studies	33% ± 9%	Explore
plasmacytoid dendritic cell	13 studies	28% ± 9%	Explore
astrocyte	11 studies	29% ± 13%	Explore
type II pneumocyte	10 studies	26% ± 12%	Explore
plasmablast	10 studies	35% ± 21%	Explore
oligodendrocyte precursor cell	10 studies	27% ± 11%	Explore
type I pneumocyte	9 studies	26% ± 7%	Explore
glutamatergic neuron	9 studies	37% ± 24%	Explore
microglial cell	9 studies	26% ± 8%	Explore
epithelial cell	9 studies	40% ± 19%	Explore
basal cell	9 studies	34% ± 17%	Explore
oligodendrocyte	9 studies	28% ± 10%	Explore
mesothelial cell	8 studies	30% ± 11%	Explore
adipocyte	8 studies	24% ± 7%	Explore
B cell	7 studies	21% ± 5%	Explore
abnormal cell	7 studies	26% ± 10%	Explore
myeloid cell	7 studies	26% ± 6%	Explore
club cell	7 studies	27% ± 9%	Explore
GABAergic neuron	7 studies	39% ± 18%	Explore
hematopoietic precursor cell	6 studies	28% ± 10%	Explore
respiratory goblet cell	6 studies	32% ± 13%	Explore
secretory cell	6 studies	22% ± 8%	Explore
CD16-negative, CD56-bright natural killer cell, human	6 studies	17% ± 2%	Explore
neuron	6 studies	34% ± 13%	Explore
interneuron	6 studies	39% ± 22%	Explore
monocyte	6 studies	23% ± 4%	Explore
dendritic cell	6 studies	28% ± 15%	Explore
goblet cell	6 studies	36% ± 22%	Explore
classical monocyte	5 studies	25% ± 9%	Explore
non-classical monocyte	5 studies	24% ± 9%	Explore
progenitor cell	5 studies	22% ± 4%	Explore
endothelial cell of artery	5 studies	16% ± 1%	Explore
mucosal invariant T cell	5 studies	18% ± 3%	Explore
pro-B cell	5 studies	34% ± 7%	Explore
CD16-positive, CD56-dim natural killer cell, human	5 studies	18% ± 3%	Explore
lymphocyte	5 studies	25% ± 7%	Explore
endothelial cell of vascular tree	5 studies	22% ± 10%	Explore
hepatocyte	5 studies	42% ± 20%	Explore
T cell	5 studies	20% ± 3%	Explore
gamma-delta T cell	5 studies	24% ± 12%	Explore
naive B cell	5 studies	19% ± 2%	Explore
duct epithelial cell	4 studies	26% ± 14%	Explore
pancreatic A cell	4 studies	36% ± 16%	Explore
CD4-positive, alpha-beta T cell	4 studies	22% ± 5%	Explore
conventional dendritic cell	4 studies	31% ± 9%	Explore
IgG plasma cell	4 studies	21% ± 4%	Explore
capillary endothelial cell	4 studies	17% ± 2%	Explore
retina horizontal cell	4 studies	22% ± 10%	Explore
mucus secreting cell	4 studies	36% ± 12%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	18% ± 1%	Explore
hematopoietic stem cell	4 studies	24% ± 6%	Explore
enteroendocrine cell	4 studies	24% ± 10%	Explore
CD8-positive, alpha-beta memory T cell	4 studies	20% ± 4%	Explore
mast cell	4 studies	20% ± 3%	Explore
memory B cell	4 studies	18% ± 5%	Explore
ionocyte	3 studies	24% ± 3%	Explore
pancreatic D cell	3 studies	40% ± 23%	Explore
type B pancreatic cell	3 studies	54% ± 18%	Explore
neural crest cell	3 studies	18% ± 2%	Explore
GABAergic interneuron	3 studies	21% ± 6%	Explore
granule cell	3 studies	19% ± 1%	Explore
immature B cell	3 studies	20% ± 3%	Explore
precursor B cell	3 studies	26% ± 10%	Explore
amacrine cell	3 studies	25% ± 10%	Explore
retinal cone cell	3 studies	24% ± 8%	Explore
retinal pigment epithelial cell	3 studies	35% ± 13%	Explore
vein endothelial cell	3 studies	24% ± 12%	Explore
glycinergic amacrine cell	3 studies	19% ± 2%	Explore
rod bipolar cell	3 studies	18% ± 0%	Explore
muscle cell	3 studies	36% ± 13%	Explore
pancreatic ductal cell	3 studies	37% ± 15%	Explore
granulocyte monocyte progenitor cell	3 studies	26% ± 8%	Explore
intestinal crypt stem cell	3 studies	21% ± 5%	Explore
adventitial cell	3 studies	28% ± 8%	Explore
alveolar macrophage	3 studies	26% ± 8%	Explore
group 3 innate lymphoid cell	3 studies	25% ± 7%	Explore
transit amplifying cell	3 studies	38% ± 27%	Explore
CD4-positive, alpha-beta memory T cell	3 studies	21% ± 4%	Explore
myoepithelial cell	3 studies	21% ± 4%	Explore
IgA plasma cell	3 studies	26% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	14 studies	23% ± 7%	Explore
brain	13 studies	32% ± 17%	Explore
intestine	6 studies	22% ± 11%	Explore
eye	6 studies	24% ± 12%	Explore
peripheral blood	5 studies	24% ± 7%	Explore
pancreas	4 studies	39% ± 19%	Explore
adipose	4 studies	22% ± 3%	Explore
uterus	3 studies	28% ± 12%	Explore
liver	3 studies	37% ± 10%	Explore
bone marrow	3 studies	25% ± 7%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
breast	100%	6653.39	459 / 459	100%	64.45	1118 / 1118
esophagus	100%	5269.26	1445 / 1445	100%	36.92	183 / 183
pancreas	100%	8835.14	328 / 328	100%	35.45	178 / 178
prostate	100%	5915.52	245 / 245	100%	61.43	502 / 502
uterus	100%	6927.06	170 / 170	100%	38.36	458 / 459
lung	100%	6665.81	578 / 578	100%	38.01	1152 / 1155
brain	100%	4048.80	2634 / 2642	100%	43.03	704 / 705
liver	100%	4511.92	226 / 226	100%	31.95	404 / 406
thymus	100%	8082.97	653 / 653	100%	68.28	602 / 605
ovary	100%	9788.12	180 / 180	99%	26.10	425 / 430
adrenal gland	100%	8257.33	258 / 258	99%	43.31	227 / 230
bladder	100%	6522.29	21 / 21	98%	31.44	495 / 504
stomach	100%	5388.17	359 / 359	98%	33.91	279 / 286
intestine	100%	5784.56	966 / 966	97%	34.65	512 / 527
skin	100%	6861.82	1809 / 1809	97%	40.05	457 / 472
kidney	100%	3369.34	89 / 89	96%	31.15	861 / 901
adipose	100%	6883.23	1204 / 1204	0%	0	0 / 0
blood vessel	100%	7754.32	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	19.75	29 / 29
spleen	100%	4487.46	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	30.07	45 / 45
ureter	0%	0	0 / 0	100%	9.03	1 / 1
muscle	99%	2859.69	795 / 803	0%	0	0 / 0
heart	95%	3811.18	821 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	88%	26.54	70 / 80
peripheral blood	73%	2422.94	681 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

III. Associated gene sets

GO_0006620	Biological process	post-translational protein targeting to endoplasmic reticulum membrane
GO_0006614	Biological process	SRP-dependent cotranslational protein targeting to membrane
GO_0001889	Biological process	liver development
GO_0031204	Biological process	post-translational protein targeting to membrane, translocation
GO_0006612	Biological process	protein targeting to membrane
GO_0005783	Cellular component	endoplasmic reticulum
GO_0031207	Cellular component	Sec62/Sec63 complex
GO_0016020	Cellular component	membrane
GO_0008320	Molecular function	protein transmembrane transporter activity
GO_0038023	Molecular function	signaling receptor activity
GO_0005515	Molecular function	protein binding
GO_0003723	Molecular function	RNA binding

IV. Literature review

[source]

Gene name	SEC63
Protein name	SEC63-like protein isoform 2 SEC63-like (S. cerevisiae) (SEC63-like protein isoform 1) Translocation protein SEC63 homolog SEC63 homolog, protein translocation regulator
Synonyms	SEC63L hCG_34021
Description	FUNCTION: Mediates cotranslational and post-translational transport of certain precursor polypeptides across endoplasmic reticulum (ER) . Proposed to play an auxiliary role in recognition of precursors with short and apolar signal peptides. May cooperate with SEC62 and HSPA5/BiP to facilitate targeting of small presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen . Required for efficient PKD1/Polycystin-1 biogenesis and trafficking to the plasma membrane of the primary cilia (By similarity). .
Accessions	ENST00000369002.9 Q9UGP8 ENST00000429168.1 F8WB27 A0A0S2Z518 A0A0S2Z5M1 A6PVC9 ENST00000446496.1

SEC63 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review