GET4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of GET4 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0045048Biological processprotein insertion into ER membrane
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0051220Biological processcytoplasmic sequestering of protein
GO_0006620Biological processpost-translational protein targeting to endoplasmic reticulum membrane
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0036503Biological processERAD pathway
GO_0031647Biological processregulation of protein stability
GO_0036506Biological processmaintenance of unfolded protein
GO_0005730Cellular componentnucleolus
GO_0005694Cellular componentchromosome
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0071818Cellular componentBAT3 complex
GO_0005737Cellular componentcytoplasm
GO_0051087Molecular functionprotein-folding chaperone binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameGET4
Protein nameGolgi to ER traffic protein 4 homolog (Conserved edge-expressed protein) (Transmembrane domain recognition complex 35 kDa subunit) (TRC35)
Guided entry of tail-anchored proteins factor 4
SynonymsCGI-20
C7orf20
TRC35
CEE
DescriptionFUNCTION: As part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, maintains misfolded and hydrophobic patches-containing proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation . The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum . Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated and sorted to the proteasome . Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum . The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome . .

AccessionsENST00000407192.5 [Q7L5D6-2]
ENST00000412734.6
C9JHN8
ENST00000426056.1
ENST00000265857.8 [Q7L5D6-1]
C9JY46
Q7L5D6
ENST00000441491.1
C9JPA8