Biological process

integral ER membrane protein localization, integral ER membrane protein positioning, localization of protein in ER membrane, positioning of protein in ER membrane, protein insertion into endoplasmic reticulum membrane, protein-ER insertion, protein-endoplasmic reticulum insertion

The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane.