WDR83OS report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006457Biological processprotein folding
GO_0160063Biological processmulti-pass transmembrane protein insertion into ER membrane
GO_0045048Biological processprotein insertion into ER membrane
GO_0101031Cellular componentprotein folding chaperone complex
GO_0160064Cellular componentmulti-pass translocon complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0044183Molecular functionprotein folding chaperone
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameWDR83OS
Protein namePAT complex subunit Asterix (Protein associated with the ER translocon of 10kDa) (PAT-10) (PAT10) (WD repeat domain 83 opposite strand) (WDR83 opposite strand)
PAT complex subunit Asterix
SynonymsC19orf56
hCG_172478
My006
CGI-140
PTD008
DescriptionFUNCTION: Component of the multi-pass translocon (MPT) complex that mediates insertion of multi-pass membrane proteins into the lipid bilayer of membranes . The MPT complex takes over after the SEC61 complex: following membrane insertion of the first few transmembrane segments of proteins by the SEC61 complex, the MPT complex occludes the lateral gate of the SEC61 complex to promote insertion of subsequent transmembrane regions . Within the MPT complex, the PAT subcomplex sequesters any highly polar regions in the transmembrane domains away from the non-polar membrane environment until they can be buried in the interior of the fully assembled protein (By similarity). Within the PAT subcomplex, WDR83OS/Asterix binds to and redirects the substrate to a location behind the SEC61 complex (By similarity). .

AccessionsA0A0A0MQS5
M0R1D5
ENST00000596731.7
Q9Y284
ENST00000222190.9
ENST00000598732.1