TRAM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006986Biological processresponse to unfolded protein
GO_0006613Biological processcotranslational protein targeting to membrane
GO_0006616Biological processSRP-dependent cotranslational protein targeting to membrane, translocation
GO_0045048Biological processprotein insertion into ER membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0038023Molecular functionsignaling receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameTRAM1
Protein nameTranslocation associated membrane protein 1
Translocating chain-associated membrane protein
Translocating chain-associated membrane protein 1 (Protein TRAM1)
Translocating chain-associated membrane protein 1
SynonymsTRAM
hCG_18447
DescriptionFUNCTION: Involved in the translocation of nascent protein chains into or through the endoplasmic reticulum (ER) membrane by facilitating the proper chain positioning at the SEC61 channel . Regulates the exposure of nascent secretory protein chain to the cytosol during translocation into the ER . May affect the phospholipid bilayer in the vicinity of the lateral gate of the SEC61 channel, thereby facilitating ER protein transport . Intimately associates with transmembrane (TM) domain of nascent membrane proteins during the entire integration process into the ER membrane . Associates with the second TM domain of G-protein-coupled receptor opsin/OPSD nascent chain in the ER membrane, which may facilitate its integration into the membrane . Under conditions of ER stress, participates in the disposal of misfolded ER membrane proteins during the unfolded protein response (UPR), an integrated stress response (ISR) pathway, by selectively retrotranslocating misfolded ER-membrane proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome . .; FUNCTION: (Microbial infection) In case of cytomegalovirus infection, participates in US2- and US11-mediated ER-to-cytosol retrotranslocation and subsequent degradation of major histocompatibility complex (MHC) class I heavy chains, thereby decreasing the immune detection by cytotoxic T-cells. .

AccessionsQ15629
ENST00000262213.7 [Q15629-1]
E5RFP8
G3XAN4
ENST00000518678.1
Q6FHU7
ENST00000521425.5
Q6FHL3