GET3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015700Biological processarsenite transport
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0045048Biological processprotein insertion into ER membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005730Cellular componentnucleolus
GO_0043529Cellular componentGET complex
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0015105Molecular functionarsenite transmembrane transporter activity
GO_0032977Molecular functionmembrane insertase activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameGET3
Protein nameATPase GET3 (EC 3.6.-.-) (Arsenical pump-driving ATPase) (Arsenite-stimulated ATPase) (Guided entry of tail-anchored proteins factor 3, ATPase) (Transmembrane domain recognition complex 40 kDa ATPase subunit) (hARSA-I) (hASNA-I)
SynonymsARSA
ASNA1
TRC40
DescriptionFUNCTION: ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1/WRB and CAMLG/GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-CAMLG receptor, and returning it to the cytosol to initiate a new round of targeting. May be involved in insulin signaling. .

AccessionsO43681
ENST00000357332.8
ENST00000591090.5