GET1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045048Biological processprotein insertion into ER membrane
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0050821Biological processprotein stabilization
GO_0043529Cellular componentGET complex
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0043495Molecular functionprotein-membrane adaptor activity

IV. Literature review

[source]
Gene nameGET1
Protein nameGuided entry of tail-anchored proteins factor 1 (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein)
Guided entry of tail-anchored proteins factor 1 (Congenital heart disease 5 protein) (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein)
Guided entry of tail-anchored proteins factor 1
SynonymshCG_401226
CHD5
WRB
DescriptionFUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) . Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol . Required to ensure correct topology and ER insertion of CAMLG . .

AccessionsENST00000650376.1 [O00258-2]
ENST00000649224.1
H7BYE5
Q0VGA7
ENST00000649170.1 [O00258-1]
A0A3B3IUG4
ENST00000478273.5
ENST00000442773.1
ENST00000398753.5 [O00258-2]
ENST00000623703.3
O00258
ENST00000647911.1
ENST00000380713.7
A0A3B3IT79
ENST00000649822.1
ENST00000380708.5 [O00258-2]
ENST00000466787.1
ENST00000649499.1
ENST00000649100.1
ENST00000647678.1
A0A3B3ISE5
ENST00000415847.3
B4DLW3
A0A096LNT6
B7Z1T1
H7C384
C9JLV3
A0A096LNK8
A0A3B3ISA8