Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 17 studies | 46% ± 20% | |
| endothelial cell | 8 studies | 23% ± 8% | |
| neuron | 7 studies | 37% ± 19% | |
| retinal cone cell | 6 studies | 50% ± 25% | |
| retinal rod cell | 6 studies | 48% ± 20% | |
| fibroblast | 5 studies | 24% ± 4% | |
| astrocyte | 5 studies | 24% ± 13% | |
| epithelial cell | 4 studies | 35% ± 7% | |
| GABAergic neuron | 4 studies | 33% ± 8% | |
| glutamatergic neuron | 4 studies | 39% ± 11% | |
| retinal bipolar neuron | 3 studies | 33% ± 13% | |
| retinal ganglion cell | 3 studies | 55% ± 26% | |
| connective tissue cell | 3 studies | 24% ± 1% | |
| amacrine cell | 3 studies | 39% ± 16% | |
| Mueller cell | 3 studies | 26% ± 12% | |
| rod bipolar cell | 3 studies | 19% ± 2% | |
| oligodendrocyte precursor cell | 3 studies | 25% ± 4% | |
| interneuron | 3 studies | 33% ± 18% | |
| oligodendrocyte | 3 studies | 25% ± 4% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 3738.11 | 2642 / 2642 | 100% | 16.29 | 705 / 705 |
| ovary | 100% | 1787.12 | 180 / 180 | 100% | 6.26 | 428 / 430 |
| thymus | 100% | 1263.83 | 651 / 653 | 100% | 7.84 | 602 / 605 |
| adrenal gland | 100% | 2224.48 | 258 / 258 | 99% | 11.24 | 228 / 230 |
| prostate | 100% | 1178.98 | 244 / 245 | 99% | 6.18 | 499 / 502 |
| breast | 100% | 1218.61 | 459 / 459 | 99% | 8.11 | 1106 / 1118 |
| uterus | 100% | 1562.62 | 170 / 170 | 98% | 6.54 | 450 / 459 |
| kidney | 100% | 1473.66 | 89 / 89 | 96% | 8.55 | 865 / 901 |
| skin | 98% | 1128.69 | 1772 / 1809 | 97% | 6.31 | 459 / 472 |
| lung | 98% | 1122.19 | 568 / 578 | 97% | 5.59 | 1119 / 1155 |
| liver | 98% | 816.29 | 222 / 226 | 95% | 4.92 | 385 / 406 |
| bladder | 100% | 1099.05 | 21 / 21 | 92% | 4.75 | 465 / 504 |
| esophagus | 99% | 1315.19 | 1426 / 1445 | 93% | 4.12 | 170 / 183 |
| intestine | 100% | 1209.72 | 965 / 966 | 91% | 4.20 | 481 / 527 |
| stomach | 98% | 960.35 | 352 / 359 | 92% | 4.40 | 263 / 286 |
| pancreas | 94% | 733.38 | 307 / 328 | 96% | 4.67 | 170 / 178 |
| ureter | 0% | 0 | 0 / 0 | 100% | 2.77 | 1 / 1 |
| adipose | 100% | 1154.28 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 1292.01 | 1329 / 1335 | 0% | 0 | 0 / 0 |
| spleen | 99% | 794.66 | 239 / 241 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1013.39 | 795 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 97% | 4.17 | 28 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 4.15 | 43 / 45 |
| eye | 0% | 0 | 0 / 0 | 95% | 5.90 | 76 / 80 |
| heart | 94% | 956.76 | 808 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 48% | 421.60 | 447 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0045048 | Biological process | protein insertion into ER membrane |
| GO_0071816 | Biological process | tail-anchored membrane protein insertion into ER membrane |
| GO_0050821 | Biological process | protein stabilization |
| GO_0043529 | Cellular component | GET complex |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0043495 | Molecular function | protein-membrane adaptor activity |
| Gene name | GET1 |
| Protein name | Guided entry of tail-anchored proteins factor 1 (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein) Guided entry of tail-anchored proteins factor 1 (Congenital heart disease 5 protein) (Tail-anchored protein insertion receptor WRB) (Tryptophan-rich basic protein) Guided entry of tail-anchored proteins factor 1 |
| Synonyms | hCG_401226 CHD5 WRB |
| Description | FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (ER) . Together with CAMLG/GET2, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol . Required to ensure correct topology and ER insertion of CAMLG . . |
| Accessions | ENST00000650376.1 [O00258-2] ENST00000649224.1 H7BYE5 Q0VGA7 ENST00000649170.1 [O00258-1] A0A3B3IUG4 ENST00000478273.5 ENST00000442773.1 ENST00000398753.5 [O00258-2] ENST00000623703.3 O00258 ENST00000647911.1 ENST00000380713.7 A0A3B3IT79 ENST00000649822.1 ENST00000380708.5 [O00258-2] ENST00000466787.1 ENST00000649499.1 ENST00000649100.1 ENST00000647678.1 A0A3B3ISE5 ENST00000415847.3 B4DLW3 A0A096LNT6 B7Z1T1 H7C384 C9JLV3 A0A096LNK8 A0A3B3ISA8 |