CAMLG report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007165Biological processsignal transduction
GO_0006952Biological processdefense response
GO_0007173Biological processepidermal growth factor receptor signaling pathway
GO_0045048Biological processprotein insertion into ER membrane
GO_0016192Biological processvesicle-mediated transport
GO_0032435Biological processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
GO_0071816Biological processtail-anchored membrane protein insertion into ER membrane
GO_0001782Biological processB cell homeostasis
GO_0050821Biological processprotein stabilization
GO_0001881Biological processreceptor recycling
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0043529Cellular componentGET complex
GO_0005737Cellular componentcytoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCAMLG
Protein nameGuided entry of tail-anchored proteins factor (Calcium signal-modulating cyclophilin ligand)
Calcium modulating ligand
Guided entry of tail-anchored proteins factor CAMLG (Calcium signal-modulating cyclophilin ligand)
SynonymsGET2
CAML
DescriptionFUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum . Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol . Required for the stability of GET1 . Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium . Essential for the survival of peripheral follicular B cells (By similarity). .

FUNCTION: Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. .

AccessionsENST00000514518.1
D6RIW3
ENST00000297156.4
P49069
ENST00000677273.1
A0A7I2V3C5
ENST00000676829.1
ENST00000678771.1
A0A7I2V518
A0A7I2V377