SEC62 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
B cell	46 studies	49% ± 14%	Explore
endothelial cell	44 studies	55% ± 19%	Explore
fibroblast	42 studies	56% ± 19%	Explore
macrophage	36 studies	42% ± 14%	Explore
natural killer cell	35 studies	33% ± 7%	Explore
pericyte	34 studies	48% ± 18%	Explore
T cell	33 studies	34% ± 13%	Explore
CD8-positive, alpha-beta T cell	32 studies	34% ± 10%	Explore
CD4-positive, alpha-beta T cell	30 studies	37% ± 12%	Explore
smooth muscle cell	28 studies	44% ± 14%	Explore
plasma cell	27 studies	59% ± 20%	Explore
classical monocyte	24 studies	41% ± 11%	Explore
endothelial cell of lymphatic vessel	23 studies	55% ± 20%	Explore
epithelial cell	23 studies	45% ± 23%	Explore
conventional dendritic cell	23 studies	37% ± 12%	Explore
regulatory T cell	23 studies	34% ± 10%	Explore
mast cell	22 studies	45% ± 16%	Explore
non-classical monocyte	22 studies	36% ± 12%	Explore
monocyte	21 studies	35% ± 12%	Explore
basal cell	21 studies	48% ± 16%	Explore
memory B cell	20 studies	44% ± 10%	Explore
naive B cell	20 studies	51% ± 13%	Explore
plasmacytoid dendritic cell	20 studies	44% ± 13%	Explore
astrocyte	20 studies	38% ± 17%	Explore
connective tissue cell	19 studies	53% ± 18%	Explore
ciliated cell	18 studies	63% ± 19%	Explore
mature NK T cell	18 studies	32% ± 10%	Explore
gamma-delta T cell	17 studies	39% ± 11%	Explore
dendritic cell	16 studies	37% ± 22%	Explore
capillary endothelial cell	16 studies	48% ± 17%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	15 studies	43% ± 11%	Explore
CD16-positive, CD56-dim natural killer cell, human	14 studies	32% ± 7%	Explore
oligodendrocyte	14 studies	36% ± 15%	Explore
myofibroblast cell	14 studies	53% ± 13%	Explore
endothelial cell of artery	14 studies	52% ± 17%	Explore
erythrocyte	13 studies	44% ± 19%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	13 studies	42% ± 11%	Explore
CD16-negative, CD56-bright natural killer cell, human	13 studies	31% ± 8%	Explore
vein endothelial cell	13 studies	53% ± 15%	Explore
mucosal invariant T cell	13 studies	37% ± 9%	Explore
endothelial cell of vascular tree	13 studies	52% ± 16%	Explore
myeloid cell	13 studies	38% ± 19%	Explore
plasmablast	12 studies	59% ± 17%	Explore
CD8-positive, alpha-beta memory T cell	12 studies	39% ± 10%	Explore
secretory cell	12 studies	54% ± 17%	Explore
microglial cell	12 studies	32% ± 15%	Explore
type II pneumocyte	11 studies	47% ± 21%	Explore
CD4-positive, alpha-beta memory T cell	11 studies	33% ± 10%	Explore
glutamatergic neuron	11 studies	48% ± 19%	Explore
goblet cell	11 studies	45% ± 16%	Explore
mesothelial cell	11 studies	51% ± 17%	Explore
type I pneumocyte	10 studies	42% ± 16%	Explore
club cell	10 studies	52% ± 20%	Explore
neutrophil	10 studies	31% ± 12%	Explore
leukocyte	10 studies	39% ± 9%	Explore
GABAergic neuron	10 studies	41% ± 19%	Explore
effector memory CD8-positive, alpha-beta T cell	10 studies	40% ± 14%	Explore
abnormal cell	10 studies	48% ± 15%	Explore
oligodendrocyte precursor cell	10 studies	37% ± 12%	Explore
progenitor cell	9 studies	35% ± 14%	Explore
neuron	9 studies	54% ± 16%	Explore
IgG plasma cell	9 studies	52% ± 17%	Explore
retinal rod cell	9 studies	55% ± 22%	Explore
alveolar macrophage	8 studies	39% ± 14%	Explore
effector CD8-positive, alpha-beta T cell	7 studies	30% ± 9%	Explore
epithelial cell of proximal tubule	7 studies	44% ± 16%	Explore
IgA plasma cell	7 studies	58% ± 7%	Explore
amacrine cell	7 studies	56% ± 25%	Explore
retina horizontal cell	7 studies	60% ± 27%	Explore
retinal cone cell	7 studies	69% ± 27%	Explore
innate lymphoid cell	7 studies	41% ± 10%	Explore
T follicular helper cell	7 studies	36% ± 10%	Explore
ionocyte	6 studies	53% ± 6%	Explore
respiratory goblet cell	6 studies	53% ± 16%	Explore
mononuclear phagocyte	6 studies	42% ± 14%	Explore
kidney loop of Henle epithelial cell	6 studies	54% ± 16%	Explore
renal alpha-intercalated cell	6 studies	69% ± 7%	Explore
enterocyte	6 studies	31% ± 5%	Explore
transit amplifying cell	6 studies	26% ± 10%	Explore
retinal ganglion cell	6 studies	68% ± 32%	Explore
glial cell	6 studies	34% ± 18%	Explore
precursor B cell	6 studies	49% ± 18%	Explore
adipocyte	6 studies	22% ± 4%	Explore
effector memory CD4-positive, alpha-beta T cell	6 studies	40% ± 16%	Explore
hepatocyte	6 studies	48% ± 29%	Explore
hematopoietic precursor cell	5 studies	38% ± 18%	Explore
exhausted T cell	5 studies	35% ± 8%	Explore
effector CD4-positive, alpha-beta T cell	5 studies	35% ± 6%	Explore
kidney distal convoluted tubule epithelial cell	5 studies	64% ± 7%	Explore
enteroendocrine cell	5 studies	54% ± 18%	Explore
erythroblast	5 studies	43% ± 22%	Explore
retinal bipolar neuron	5 studies	53% ± 32%	Explore
OFF-bipolar cell	5 studies	52% ± 27%	Explore
ON-bipolar cell	5 studies	55% ± 26%	Explore
hematopoietic stem cell	5 studies	33% ± 6%	Explore
pro-B cell	5 studies	33% ± 12%	Explore
brush cell	5 studies	31% ± 12%	Explore
neuroendocrine cell	5 studies	69% ± 25%	Explore
immature B cell	5 studies	54% ± 12%	Explore
mucus secreting cell	5 studies	60% ± 27%	Explore
Mueller cell	5 studies	55% ± 25%	Explore
interneuron	5 studies	54% ± 17%	Explore
deuterosomal cell	4 studies	37% ± 8%	Explore
duct epithelial cell	4 studies	57% ± 6%	Explore
pancreatic A cell	4 studies	75% ± 10%	Explore
type B pancreatic cell	4 studies	77% ± 14%	Explore
glomerular endothelial cell	4 studies	66% ± 15%	Explore
intestinal crypt stem cell	4 studies	29% ± 7%	Explore
glycinergic amacrine cell	4 studies	42% ± 18%	Explore
lymphocyte	4 studies	44% ± 21%	Explore
retinal pigment epithelial cell	4 studies	51% ± 24%	Explore
adventitial cell	4 studies	54% ± 9%	Explore
cardiac muscle cell	4 studies	20% ± 2%	Explore
acinar cell	4 studies	56% ± 20%	Explore
endothelial cell of sinusoid	4 studies	32% ± 13%	Explore
muscle cell	4 studies	40% ± 21%	Explore
germinal center B cell	4 studies	42% ± 17%	Explore
intermediate monocyte	4 studies	49% ± 21%	Explore
CD4-positive helper T cell	4 studies	42% ± 14%	Explore
luminal hormone-sensing cell of mammary gland	4 studies	61% ± 2%	Explore
granulocyte	4 studies	42% ± 11%	Explore
luminal cell of prostate epithelium	4 studies	39% ± 12%	Explore
effector memory CD8-positive, alpha-beta T cell, terminally differentiated	4 studies	35% ± 10%	Explore
double negative thymocyte	4 studies	47% ± 13%	Explore
squamous epithelial cell	3 studies	46% ± 22%	Explore
pancreatic D cell	3 studies	80% ± 12%	Explore
kidney connecting tubule epithelial cell	3 studies	71% ± 14%	Explore
podocyte	3 studies	70% ± 13%	Explore
neural crest cell	3 studies	38% ± 1%	Explore
GABAergic interneuron	3 studies	31% ± 13%	Explore
GABAergic amacrine cell	3 studies	58% ± 9%	Explore
renal principal cell	3 studies	78% ± 12%	Explore
extravillous trophoblast	3 studies	56% ± 14%	Explore
placental villous trophoblast	3 studies	57% ± 5%	Explore
serous secreting cell	3 studies	61% ± 21%	Explore
tissue-resident macrophage	3 studies	36% ± 11%	Explore
intraepithelial lymphocyte	3 studies	42% ± 20%	Explore
rod bipolar cell	3 studies	67% ± 18%	Explore
chondrocyte	3 studies	44% ± 21%	Explore
myoepithelial cell	3 studies	54% ± 9%	Explore
inflammatory macrophage	3 studies	30% ± 3%	Explore
IgM plasma cell	3 studies	57% ± 13%	Explore
pancreatic ductal cell	3 studies	71% ± 15%	Explore
group 3 innate lymphoid cell	3 studies	49% ± 9%	Explore
melanocyte	3 studies	41% ± 3%	Explore
keratinocyte	3 studies	27% ± 7%	Explore
T-helper 17 cell	3 studies	43% ± 6%	Explore
granule cell	3 studies	33% ± 14%	Explore
T-helper 1 cell	3 studies	35% ± 12%	Explore
central memory CD4-positive, alpha-beta T cell	3 studies	43% ± 6%	Explore
central memory CD8-positive, alpha-beta T cell	3 studies	39% ± 12%	Explore
progenitor cell of mammary luminal epithelium	3 studies	35% ± 6%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
lung	19 studies	51% ± 15%	Explore
brain	19 studies	41% ± 16%	Explore
peripheral blood	18 studies	41% ± 12%	Explore
intestine	12 studies	40% ± 16%	Explore
eye	12 studies	52% ± 21%	Explore
kidney	9 studies	44% ± 9%	Explore
liver	7 studies	46% ± 19%	Explore
bone marrow	6 studies	34% ± 9%	Explore
pancreas	5 studies	64% ± 21%	Explore
uterus	5 studies	59% ± 16%	Explore
prostate	5 studies	33% ± 9%	Explore
lymph node	5 studies	45% ± 6%	Explore
placenta	4 studies	49% ± 16%	Explore
breast	4 studies	49% ± 8%	Explore
adipose	4 studies	31% ± 11%	Explore
heart	3 studies	31% ± 5%	Explore
adrenal gland	3 studies	41% ± 4%	Explore
skin	3 studies	38% ± 7%	Explore
thymus	3 studies	48% ± 13%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	100%	11682.50	2642 / 2642	100%	89.79	705 / 705
breast	100%	8108.52	459 / 459	100%	84.93	1118 / 1118
esophagus	100%	6600.64	1445 / 1445	100%	94.62	183 / 183
lung	100%	7889.40	578 / 578	100%	83.57	1155 / 1155
ovary	100%	7283.28	180 / 180	100%	67.84	430 / 430
pancreas	100%	6293.90	328 / 328	100%	57.50	178 / 178
prostate	100%	7997.28	245 / 245	100%	96.86	502 / 502
thymus	100%	10603.17	653 / 653	100%	98.44	605 / 605
uterus	100%	7902.07	170 / 170	100%	58.13	459 / 459
liver	100%	6488.26	226 / 226	100%	45.51	405 / 406
bladder	100%	7619.62	21 / 21	99%	48.02	500 / 504
adrenal gland	100%	8605.04	258 / 258	99%	63.18	228 / 230
kidney	100%	6207.57	89 / 89	99%	77.82	893 / 901
stomach	100%	7079.26	359 / 359	98%	61.78	280 / 286
intestine	100%	7566.58	966 / 966	98%	53.98	515 / 527
skin	100%	5369.47	1800 / 1809	92%	46.76	433 / 472
adipose	100%	8942.50	1204 / 1204	0%	0	0 / 0
blood vessel	100%	8068.74	1335 / 1335	0%	0	0 / 0
lymph node	0%	0	0 / 0	100%	54.49	29 / 29
spleen	100%	7177.23	241 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	100%	23.98	1 / 1
muscle	99%	3505.99	794 / 803	0%	0	0 / 0
heart	98%	4073.76	847 / 861	0%	0	0 / 0
tonsil	0%	0	0 / 0	98%	52.91	44 / 45
peripheral blood	95%	5455.65	884 / 929	0%	0	0 / 0
eye	0%	0	0 / 0	55%	14.22	44 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

IV. Literature review

[source]

Gene name	SEC62
Protein name	Translocation protein SEC62 (Translocation protein 1) (TP-1) (hTP-1) SEC62 homolog, preprotein translocation factor Translocation protein SEC62
Synonyms	TLOC1
Description	FUNCTION: Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen. .
Accessions	ENST00000469515.6 F8WDG8 F8WF48 ENST00000337002.9 F8WCJ7 Q99442 A0JLN5 ENST00000460513.5 Q3KR08 ENST00000480708.5 ENST00000487736.5

GO_0006620	Biological process	post-translational protein targeting to endoplasmic reticulum membrane
GO_0006613	Biological process	cotranslational protein targeting to membrane
GO_0031204	Biological process	post-translational protein targeting to membrane, translocation
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005791	Cellular component	rough endoplasmic reticulum
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0038023	Molecular function	signaling receptor activity

SEC62 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review