FAF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042176Biological processregulation of protein catabolic process
GO_1902043Biological processpositive regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO_0031334Biological processpositive regulation of protein-containing complex assembly
GO_0045732Biological processpositive regulation of protein catabolic process
GO_0007253Biological processcytoplasmic sequestering of NF-kappaB
GO_0045740Biological processpositive regulation of DNA replication
GO_0006915Biological processapoptotic process
GO_0030155Biological processregulation of cell adhesion
GO_0043065Biological processpositive regulation of apoptotic process
GO_0036503Biological processERAD pathway
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005654Cellular componentnucleoplasm
GO_0031265Cellular componentCD95 death-inducing signaling complex
GO_0034098Cellular componentVCP-NPL4-UFD1 AAA ATPase complex
GO_0005635Cellular componentnuclear envelope
GO_1990917Cellular componentooplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0019904Molecular functionprotein domain specific binding
GO_0019887Molecular functionprotein kinase regulator activity
GO_0031072Molecular functionheat shock protein binding
GO_0019901Molecular functionprotein kinase binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0005515Molecular functionprotein binding
GO_0043130Molecular functionubiquitin binding
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameFAF1
Protein nameFas associated factor 1 (cDNA FLJ37524 fis, clone BRCAN2007119, highly similar to FAS-associated factor 1)
FAS-associated factor 1 (hFAF1) (UBX domain-containing protein 12) (UBX domain-containing protein 3A)
SynonymsUBXD12
CGI-03
UBXN3A
DescriptionFUNCTION: Ubiquitin-binding protein . Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation . Potentiates but cannot initiate FAS-induced apoptosis (By similarity). .

AccessionsENST00000396153.7 [Q9UNN5-1]
ENST00000494400.5
Q9UNN5
B3KT28