APIP report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006915Biological processapoptotic process
GO_0019509Biological processL-methionine salvage from methylthioadenosine
GO_0070269Biological processpyroptotic inflammatory response
GO_0043066Biological processnegative regulation of apoptotic process
GO_0019284Biological processL-methionine salvage from S-adenosylmethionine
GO_0070372Biological processregulation of ERK1 and ERK2 cascade
GO_0051289Biological processprotein homotetramerization
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0046570Molecular functionmethylthioribulose 1-phosphate dehydratase activity
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameAPIP
Protein nameMethylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP)
APAF1 interacting protein
Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein)
SynonymsCGI-29
DescriptionFUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. .

FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. .

AccessionsS4R3D6
B4DY17
Q96GX9
ENST00000532428.6
ENST00000395787.4 [Q96GX9-1]