Name | Number of supported studies | Average coverage | |
---|---|---|---|
macrophage | 10 studies | 25% ± 11% | |
endothelial cell | 7 studies | 23% ± 6% | |
epithelial cell | 6 studies | 34% ± 11% | |
oligodendrocyte | 6 studies | 25% ± 7% | |
classical monocyte | 5 studies | 19% ± 4% | |
alveolar macrophage | 5 studies | 31% ± 6% | |
adipocyte | 5 studies | 20% ± 2% | |
glutamatergic neuron | 4 studies | 36% ± 12% | |
conventional dendritic cell | 3 studies | 35% ± 12% | |
kidney loop of Henle epithelial cell | 3 studies | 21% ± 3% | |
microglial cell | 3 studies | 18% ± 1% | |
myeloid cell | 3 studies | 21% ± 4% | |
fibroblast | 3 studies | 23% ± 3% | |
ciliated cell | 3 studies | 35% ± 6% | |
GABAergic neuron | 3 studies | 38% ± 2% | |
dendritic cell | 3 studies | 39% ± 1% | |
intestinal crypt stem cell | 3 studies | 18% ± 4% | |
basal cell | 3 studies | 38% ± 12% | |
neuron | 3 studies | 27% ± 6% | |
plasmacytoid dendritic cell | 3 studies | 23% ± 3% | |
astrocyte | 3 studies | 33% ± 6% | |
oligodendrocyte precursor cell | 3 studies | 26% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 909.54 | 1445 / 1445 | 100% | 9.44 | 183 / 183 |
lung | 100% | 1158.10 | 578 / 578 | 100% | 9.41 | 1155 / 1155 |
prostate | 100% | 1270.98 | 245 / 245 | 100% | 13.50 | 502 / 502 |
brain | 100% | 893.94 | 2639 / 2642 | 100% | 10.06 | 705 / 705 |
breast | 100% | 1305.24 | 459 / 459 | 100% | 12.68 | 1116 / 1118 |
ovary | 100% | 942.46 | 180 / 180 | 100% | 10.33 | 429 / 430 |
stomach | 100% | 1102.94 | 359 / 359 | 100% | 13.58 | 285 / 286 |
intestine | 100% | 1120.31 | 966 / 966 | 99% | 13.91 | 524 / 527 |
thymus | 100% | 1242.21 | 652 / 653 | 100% | 13.12 | 602 / 605 |
pancreas | 99% | 716.22 | 326 / 328 | 99% | 9.28 | 177 / 178 |
kidney | 100% | 1143.45 | 89 / 89 | 99% | 8.23 | 890 / 901 |
uterus | 100% | 1150.14 | 170 / 170 | 99% | 10.00 | 453 / 459 |
bladder | 100% | 1075.33 | 21 / 21 | 99% | 10.02 | 497 / 504 |
liver | 99% | 552.96 | 223 / 226 | 99% | 8.88 | 400 / 406 |
adrenal gland | 100% | 1744.12 | 258 / 258 | 96% | 8.19 | 221 / 230 |
skin | 100% | 723.53 | 1805 / 1809 | 96% | 7.92 | 452 / 472 |
lymph node | 0% | 0 | 0 / 0 | 100% | 12.39 | 29 / 29 |
muscle | 100% | 1122.41 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 1023.63 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 2.87 | 1 / 1 |
adipose | 100% | 1276.24 | 1203 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 959.46 | 1333 / 1335 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 7.32 | 44 / 45 |
heart | 98% | 665.71 | 840 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 93% | 5.30 | 74 / 80 |
peripheral blood | 63% | 499.97 | 588 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006915 | Biological process | apoptotic process |
GO_0019509 | Biological process | L-methionine salvage from methylthioadenosine |
GO_0070269 | Biological process | pyroptotic inflammatory response |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0019284 | Biological process | L-methionine salvage from S-adenosylmethionine |
GO_0070372 | Biological process | regulation of ERK1 and ERK2 cascade |
GO_0051289 | Biological process | protein homotetramerization |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0046570 | Molecular function | methylthioribulose 1-phosphate dehydratase activity |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
Gene name | APIP |
Protein name | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP) APAF1 interacting protein Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) |
Synonyms | CGI-29 |
Description | FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. . FUNCTION: Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. . |
Accessions | S4R3D6 B4DY17 Q96GX9 ENST00000532428.6 ENST00000395787.4 [Q96GX9-1] |