GLRX2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of GLRX2 at tissue level.

III. Associated gene sets

GO_0045454Biological processcell redox homeostasis
GO_0009966Biological processregulation of signal transduction
GO_0009266Biological processresponse to temperature stimulus
GO_0051775Biological processresponse to redox state
GO_0042262Biological processDNA protection
GO_0030154Biological processcell differentiation
GO_0071451Biological processcellular response to superoxide
GO_0006355Biological processregulation of DNA-templated transcription
GO_0006915Biological processapoptotic process
GO_0006749Biological processglutathione metabolic process
GO_0005739Cellular componentmitochondrion
GO_0005654Cellular componentnucleoplasm
GO_0043025Cellular componentneuronal cell body
GO_0030425Cellular componentdendrite
GO_0005759Cellular componentmitochondrial matrix
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005634Cellular componentnucleus
GO_0008794Molecular functionarsenate reductase (glutaredoxin) activity
GO_0009055Molecular functionelectron transfer activity
GO_0015035Molecular functionprotein-disulfide reductase activity
GO_0046872Molecular functionmetal ion binding
GO_0003756Molecular functionprotein disulfide isomerase activity
GO_0051537Molecular function2 iron, 2 sulfur cluster binding
GO_0005515Molecular functionprotein binding
GO_0015038Molecular functionglutathione disulfide oxidoreductase activity

IV. Literature review

[source]
Gene nameGLRX2
Protein nameGlutaredoxin-2, mitochondrial
SynonymsCGI-133
GRX2
DescriptionFUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. .

FUNCTION: Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release. .

AccessionsENST00000367439.8 [Q9NS18-1]
A0JLT0
ENST00000367440.3 [Q9NS18-2]
ENST00000608166.2 [Q9NS18-1]
Q9NS18