IFI6 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
endothelial cell	28 studies	40% ± 17%	Explore
fibroblast	27 studies	28% ± 13%	Explore
macrophage	25 studies	35% ± 16%	Explore
classical monocyte	22 studies	31% ± 14%	Explore
non-classical monocyte	21 studies	37% ± 16%	Explore
CD8-positive, alpha-beta T cell	17 studies	27% ± 12%	Explore
ciliated cell	16 studies	32% ± 14%	Explore
regulatory T cell	15 studies	32% ± 10%	Explore
conventional dendritic cell	14 studies	29% ± 12%	Explore
monocyte	13 studies	39% ± 20%	Explore
natural killer cell	13 studies	36% ± 12%	Explore
capillary endothelial cell	13 studies	32% ± 10%	Explore
CD16-positive, CD56-dim natural killer cell, human	12 studies	28% ± 8%	Explore
T cell	12 studies	25% ± 12%	Explore
endothelial cell of artery	12 studies	41% ± 13%	Explore
pericyte	11 studies	34% ± 21%	Explore
gamma-delta T cell	11 studies	25% ± 7%	Explore
endothelial cell of vascular tree	11 studies	32% ± 12%	Explore
CD4-positive, alpha-beta T cell	10 studies	23% ± 7%	Explore
CD8-positive, alpha-beta memory T cell	9 studies	27% ± 11%	Explore
epithelial cell	9 studies	33% ± 22%	Explore
connective tissue cell	9 studies	30% ± 8%	Explore
plasmablast	8 studies	43% ± 17%	Explore
CD4-positive, alpha-beta memory T cell	8 studies	22% ± 5%	Explore
CD16-negative, CD56-bright natural killer cell, human	8 studies	30% ± 7%	Explore
naive thymus-derived CD8-positive, alpha-beta T cell	8 studies	25% ± 4%	Explore
mucosal invariant T cell	8 studies	23% ± 5%	Explore
vein endothelial cell	8 studies	26% ± 9%	Explore
alveolar macrophage	7 studies	48% ± 20%	Explore
plasma cell	7 studies	42% ± 15%	Explore
dendritic cell	7 studies	34% ± 12%	Explore
mature NK T cell	7 studies	29% ± 9%	Explore
naive thymus-derived CD4-positive, alpha-beta T cell	7 studies	24% ± 2%	Explore
endothelial cell of lymphatic vessel	7 studies	33% ± 18%	Explore
abnormal cell	6 studies	33% ± 18%	Explore
myeloid cell	6 studies	45% ± 16%	Explore
type I pneumocyte	6 studies	34% ± 11%	Explore
secretory cell	5 studies	27% ± 5%	Explore
B cell	5 studies	18% ± 3%	Explore
effector memory CD8-positive, alpha-beta T cell	5 studies	29% ± 4%	Explore
smooth muscle cell	5 studies	32% ± 9%	Explore
basal cell	5 studies	27% ± 9%	Explore
effector CD8-positive, alpha-beta T cell	5 studies	32% ± 10%	Explore
hematopoietic stem cell	5 studies	30% ± 15%	Explore
naive B cell	5 studies	22% ± 7%	Explore
platelet	4 studies	29% ± 8%	Explore
pancreatic A cell	4 studies	52% ± 9%	Explore
type B pancreatic cell	4 studies	33% ± 9%	Explore
exhausted T cell	4 studies	33% ± 9%	Explore
glomerular endothelial cell	4 studies	48% ± 9%	Explore
effector CD4-positive, alpha-beta T cell	4 studies	27% ± 4%	Explore
intermediate monocyte	4 studies	35% ± 18%	Explore
brush cell	4 studies	61% ± 19%	Explore
club cell	3 studies	22% ± 5%	Explore
duct epithelial cell	3 studies	26% ± 16%	Explore
respiratory goblet cell	3 studies	36% ± 4%	Explore
squamous epithelial cell	3 studies	22% ± 8%	Explore
kidney loop of Henle epithelial cell	3 studies	25% ± 8%	Explore
extravillous trophoblast	3 studies	79% ± 14%	Explore
placental villous trophoblast	3 studies	96% ± 5%	Explore
common myeloid progenitor	3 studies	33% ± 18%	Explore
innate lymphoid cell	3 studies	33% ± 4%	Explore
Mueller cell	3 studies	24% ± 4%	Explore
GABAergic neuron	3 studies	22% ± 2%	Explore
effector memory CD4-positive, alpha-beta T cell	3 studies	25% ± 8%	Explore
goblet cell	3 studies	17% ± 1%	Explore
mononuclear phagocyte	3 studies	26% ± 4%	Explore
T-helper 1 cell	3 studies	19% ± 4%	Explore
memory B cell	3 studies	18% ± 2%	Explore
double negative thymocyte	3 studies	38% ± 9%	Explore
CD4-positive, alpha-beta cytotoxic T cell	3 studies	29% ± 12%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
peripheral blood	16 studies	26% ± 9%	Explore
lung	15 studies	24% ± 7%	Explore
placenta	5 studies	54% ± 30%	Explore
pancreas	4 studies	37% ± 11%	Explore
kidney	4 studies	24% ± 7%	Explore
uterus	3 studies	43% ± 12%	Explore
lymph node	3 studies	39% ± 15%	Explore
brain	3 studies	20% ± 3%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
ovary	99%	2644.34	179 / 180	95%	3586.79	408 / 430
thymus	100%	6017.26	652 / 653	82%	814.81	498 / 605
adrenal gland	100%	5342.77	258 / 258	79%	1367.84	182 / 230
breast	98%	2470.38	452 / 459	79%	1610.02	884 / 1118
uterus	98%	2250.30	167 / 170	78%	1377.90	359 / 459
lung	100%	4983.65	577 / 578	67%	774.17	772 / 1155
bladder	100%	1441.90	21 / 21	62%	971.63	311 / 504
brain	100%	4079.48	2639 / 2642	54%	710.35	381 / 705
esophagus	75%	1651.37	1083 / 1445	77%	1040.64	141 / 183
intestine	93%	1989.31	898 / 966	58%	548.64	307 / 527
prostate	98%	2050.35	240 / 245	52%	661.25	261 / 502
skin	70%	1141.71	1263 / 1809	77%	1377.69	362 / 472
stomach	79%	1768.52	283 / 359	63%	656.60	181 / 286
pancreas	46%	752.31	150 / 328	88%	1161.55	157 / 178
kidney	97%	5924.02	86 / 89	35%	180.07	315 / 901
liver	76%	2198.77	171 / 226	42%	417.31	172 / 406
spleen	100%	2946.47	241 / 241	0%	0	0 / 0
adipose	99%	2722.73	1191 / 1204	0%	0	0 / 0
blood vessel	99%	4033.44	1317 / 1335	0%	0	0 / 0
heart	97%	2259.43	838 / 861	0%	0	0 / 0
peripheral blood	85%	3802.41	793 / 929	0%	0	0 / 0
tonsil	0%	0	0 / 0	80%	796.47	36 / 45
eye	0%	0	0 / 0	35%	336.88	28 / 80
lymph node	0%	0	0 / 0	34%	260.42	10 / 29
muscle	17%	223.32	133 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0043154	Biological process	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0097190	Biological process	apoptotic signaling pathway
GO_0045087	Biological process	innate immune response
GO_0051607	Biological process	defense response to virus
GO_0042058	Biological process	regulation of epidermal growth factor receptor signaling pathway
GO_0072593	Biological process	reactive oxygen species metabolic process
GO_0006955	Biological process	immune response
GO_0098586	Biological process	cellular response to virus
GO_0097193	Biological process	intrinsic apoptotic signaling pathway
GO_0043066	Biological process	negative regulation of apoptotic process
GO_0051902	Biological process	negative regulation of mitochondrial depolarization
GO_0001836	Biological process	release of cytochrome c from mitochondria
GO_0006915	Biological process	apoptotic process
GO_2001240	Biological process	negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
GO_0005886	Cellular component	plasma membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_0031966	Cellular component	mitochondrial membrane
GO_0005743	Cellular component	mitochondrial inner membrane
GO_0005515	Molecular function	protein binding

IV. Literature review

[source]

Gene name	IFI6
Protein name	Interferon alpha-inducible protein 6 (Interferon-induced protein 6-16) (Ifi-6-16) Interferon alpha-inducible protein 6
Synonyms	G1P3
Description	FUNCTION: Interferon-stimulated protein that plays an important role in innate immune response against a wide variety of viruses . Inhibits flavivirus replication by preventing the formation of virus-induced endoplasmic reticulum membrane invaginations, which are double-membrane vesicles that flaviviruses use for their replication . Has an antiviral activity towards hepatitis C virus/HCV by inhibiting the EGFR signaling pathway, whose activation is required for entry of the virus into cells . Within the nucleus, restricts hepatitis B virus/HBV promoter activity leading to substantial reduction of viral replication and gene expression . Plays a role in apoptosis, negatively regulating the intrinsinc apoptotic signaling pathway and TNFSF10-induced apoptosis . However, it has also been shown to have a pro-apoptotic activity . Modulates innate immune response mediated by RIGI by preventing its activation . .
Accessions	ENST00000679644.1 [P09912-1] A0A348GSI1 ENST00000362020.4 [P09912-2] ENST00000339145.8 [P09912-3] P09912 ENST00000361157.11 [P09912-1]

IFI6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review