PRKCI report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018105Biological processpeptidyl-serine phosphorylation
GO_0062197Biological processcellular response to chemical stress
GO_0046326Biological processpositive regulation of glucose import
GO_0032869Biological processcellular response to insulin stimulus
GO_0010976Biological processpositive regulation of neuron projection development
GO_0060252Biological processpositive regulation of glial cell proliferation
GO_0061024Biological processmembrane organization
GO_0007010Biological processcytoskeleton organization
GO_0006612Biological processprotein targeting to membrane
GO_0070555Biological processresponse to interleukin-1
GO_0099072Biological processregulation of postsynaptic membrane neurotransmitter receptor levels
GO_0045216Biological processcell-cell junction organization
GO_0035089Biological processestablishment of apical/basal cell polarity
GO_0042462Biological processeye photoreceptor cell development
GO_0046903Biological processsecretion
GO_0045197Biological processestablishment or maintenance of epithelial cell apical/basal polarity
GO_1903078Biological processpositive regulation of protein localization to plasma membrane
GO_0016192Biological processvesicle-mediated transport
GO_0048194Biological processGolgi vesicle budding
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007015Biological processactin filament organization
GO_0034351Biological processnegative regulation of glial cell apoptotic process
GO_0045747Biological processpositive regulation of Notch signaling pathway
GO_0006468Biological processprotein phosphorylation
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_2000353Biological processpositive regulation of endothelial cell apoptotic process
GO_0016477Biological processcell migration
GO_0005903Cellular componentbrush border
GO_0016324Cellular componentapical plasma membrane
GO_0098978Cellular componentglutamatergic synapse
GO_0070160Cellular componenttight junction
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0031252Cellular componentcell leading edge
GO_0045171Cellular componentintercellular bridge
GO_0043220Cellular componentSchmidt-Lanterman incisure
GO_0000139Cellular componentGolgi membrane
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0120157Cellular componentPAR polarity complex
GO_0005923Cellular componentbicellular tight junction
GO_0005768Cellular componentendosome
GO_0005634Cellular componentnucleus
GO_0106310Molecular functionprotein serine kinase activity
GO_0005543Molecular functionphospholipid binding
GO_0004674Molecular functionprotein serine/threonine kinase activity
GO_0004672Molecular functionprotein kinase activity
GO_0046872Molecular functionmetal ion binding
GO_0005524Molecular functionATP binding
GO_0004697Molecular functiondiacylglycerol-dependent serine/threonine kinase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene namePRKCI
Protein nameProtein kinase C iota type (EC 2.7.11.13) (Atypical protein kinase C-lambda/iota) (PRKC-lambda/iota) (aPKC-lambda/iota) (nPKC-iota)
Protein kinase C iota type (EC 2.7.11.13) (nPKC-iota)
SynonymsDXS1179E
DescriptionFUNCTION: Calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway. Is necessary for BCR-ABL oncogene-mediated resistance to apoptotic drug in leukemia cells, protecting leukemia cells against drug-induced apoptosis. In cultured neurons, prevents amyloid beta protein-induced apoptosis by interrupting cell death process at a very early step. In glioblastoma cells, may function downstream of phosphatidylinositol 3-kinase (PI(3)K) and PDPK1 in the promotion of cell survival by phosphorylating and inhibiting the pro-apoptotic factor BAD. Can form a protein complex in non-small cell lung cancer (NSCLC) cells with PARD6A and ECT2 and regulate ECT2 oncogenic activity by phosphorylation, which in turn promotes transformed growth and invasion. In response to nerve growth factor (NGF), acts downstream of SRC to phosphorylate and activate IRAK1, allowing the subsequent activation of NF-kappa-B and neuronal cell survival. Functions in the organization of the apical domain in epithelial cells by phosphorylating EZR. This step is crucial for activation and normal distribution of EZR at the early stages of intestinal epithelial cell differentiation. Forms a protein complex with LLGL1 and PARD6B independently of PARD3 to regulate epithelial cell polarity. Plays a role in microtubule dynamics in the early secretory pathway through interaction with RAB2A and GAPDH and recruitment to vesicular tubular clusters (VTCs). In human coronary artery endothelial cells (HCAEC), is activated by saturated fatty acids and mediates lipid-induced apoptosis. Involved in early synaptic long term potentiation phase in CA1 hippocampal cells and short term memory formation (By similarity). .

AccessionsP41743
B5BUK7
ENST00000295797.5