I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 30% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| transit amplifying cell | 3 studies | 30% ± 6% |
Insufficient scRNA-seq data for expression of STIL at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 98% | 171.76 | 452 / 459 | 95% | 9.51 | 1059 / 1118 |
| ovary | 94% | 115.16 | 170 / 180 | 98% | 9.59 | 420 / 430 |
| stomach | 92% | 185.46 | 331 / 359 | 98% | 13.33 | 281 / 286 |
| lung | 96% | 186.04 | 553 / 578 | 94% | 8.52 | 1081 / 1155 |
| skin | 100% | 604.90 | 1803 / 1809 | 88% | 6.59 | 415 / 472 |
| uterus | 88% | 92.62 | 149 / 170 | 96% | 13.95 | 442 / 459 |
| bladder | 90% | 104.33 | 19 / 21 | 93% | 9.16 | 470 / 504 |
| intestine | 82% | 355.53 | 796 / 966 | 98% | 11.93 | 518 / 527 |
| prostate | 98% | 206.32 | 239 / 245 | 82% | 3.91 | 410 / 502 |
| esophagus | 75% | 241.77 | 1077 / 1445 | 100% | 17.16 | 183 / 183 |
| pancreas | 83% | 86.07 | 272 / 328 | 82% | 4.29 | 146 / 178 |
| brain | 94% | 124.67 | 2487 / 2642 | 47% | 2.75 | 331 / 705 |
| kidney | 91% | 142.08 | 81 / 89 | 33% | 1.15 | 300 / 901 |
| thymus | 98% | 125.58 | 641 / 653 | 21% | 1.34 | 127 / 605 |
| liver | 75% | 84.14 | 169 / 226 | 38% | 1.93 | 154 / 406 |
| adrenal gland | 93% | 123.06 | 239 / 258 | 14% | 0.62 | 32 / 230 |
| spleen | 100% | 371.37 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 17.33 | 45 / 45 |
| adipose | 96% | 140.78 | 1160 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 86% | 7.66 | 25 / 29 |
| blood vessel | 58% | 54.68 | 768 / 1335 | 0% | 0 | 0 / 0 |
| heart | 55% | 44.85 | 473 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 50% | 717.41 | 460 / 929 | 0% | 0 | 0 / 0 |
| muscle | 30% | 23.07 | 242 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 11% | 0.28 | 9 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007224 | Biological process | smoothened signaling pathway |
| GO_0046601 | Biological process | positive regulation of centriole replication |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0007368 | Biological process | determination of left/right symmetry |
| GO_0001947 | Biological process | heart looping |
| GO_0030900 | Biological process | forebrain development |
| GO_0007052 | Biological process | mitotic spindle organization |
| GO_0051298 | Biological process | centrosome duplication |
| GO_0071539 | Biological process | protein localization to centrosome |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_1905832 | Biological process | positive regulation of spindle assembly |
| GO_0046599 | Biological process | regulation of centriole replication |
| GO_1900087 | Biological process | positive regulation of G1/S transition of mitotic cell cycle |
| GO_0043066 | Biological process | negative regulation of apoptotic process |
| GO_0001843 | Biological process | neural tube closure |
| GO_0000578 | Biological process | embryonic axis specification |
| GO_0060236 | Biological process | regulation of mitotic spindle organization |
| GO_0021915 | Biological process | neural tube development |
| GO_0030903 | Biological process | notochord development |
| GO_0033504 | Biological process | floor plate development |
| GO_0005813 | Cellular component | centrosome |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005814 | Cellular component | centriole |
| GO_0005829 | Cellular component | cytosol |
| GO_0005938 | Cellular component | cell cortex |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0120099 | Cellular component | procentriole replication complex |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | STIL |
| Protein name | STIL protein SCL-interrupting locus protein (TAL-1-interrupting locus protein) STIL centriolar assembly protein SCL/TAL1 interrupting locus |
| Synonyms | RP1-18D14.8-006 RP1-18D14.8-002 SIL RP1-18D14.8-003 |
| Description | FUNCTION: Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1 . Plays an important role in the regulation of centriole duplication. Required for the onset of procentriole formation and proper mitotic progression. During procentriole formation, is essential for the correct loading of SASS6 and CENPJ to the base of the procentriole to initiate procentriole assembly . In complex with STIL acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility . . |
| Accessions | Q5T0D4 B1AL49 Q5T0C7 A0A804HJM8 Q15468 ENST00000337817.10 ENST00000396221.6 Q5T0D0 ENST00000683977.1 ENST00000682977.1 ENST00000371877.8 [Q15468-2] E9PSF2 H0Y702 ENST00000447475.7 B7ZLW5 ENST00000360380.7 [Q15468-1] ENST00000436811.2 A0A0A0MR87 Q7Z626 |
