CBS report

I. Expression across cell types

Insufficient scRNA-seq data for expression of CBS at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of CBS at tissue level.

III. Associated gene sets

GO_0010749Biological processregulation of nitric oxide mediated signal transduction
GO_0001974Biological processblood vessel remodeling
GO_0019346Biological processtranssulfuration
GO_0019344Biological processcysteine biosynthetic process
GO_0001958Biological processendochondral ossification
GO_0097746Biological processblood vessel diameter maintenance
GO_0019343Biological processcysteine biosynthetic process via cystathionine
GO_0043066Biological processnegative regulation of apoptotic process
GO_0006565Biological processL-serine catabolic process
GO_0042262Biological processDNA protection
GO_0070814Biological processhydrogen sulfide biosynthetic process
GO_0050667Biological processhomocysteine metabolic process
GO_0051593Biological processresponse to folic acid
GO_0043418Biological processhomocysteine catabolic process
GO_0021587Biological processcerebellum morphogenesis
GO_0019448Biological processL-cysteine catabolic process
GO_0006801Biological processsuperoxide metabolic process
GO_0060351Biological processcartilage development involved in endochondral bone morphogenesis
GO_0006535Biological processcysteine biosynthetic process from serine
GO_0071456Biological processcellular response to hypoxia
GO_0060135Biological processmaternal process involved in female pregnancy
GO_0006563Biological processL-serine metabolic process
GO_0005634Cellular componentnucleus
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0019899Molecular functionenzyme binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004122Molecular functioncystathionine beta-synthase activity
GO_0030170Molecular functionpyridoxal phosphate binding
GO_0070026Molecular functionnitric oxide binding
GO_1904047Molecular functionS-adenosyl-L-methionine binding
GO_0070025Molecular functioncarbon monoxide binding
GO_0042802Molecular functionidentical protein binding
GO_0031625Molecular functionubiquitin protein ligase binding
GO_0019825Molecular functionoxygen binding
GO_0050421Molecular functionnitrite reductase (NO-forming) activity
GO_0020037Molecular functionheme binding
GO_0072341Molecular functionmodified amino acid binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameCBS
Protein nameCystathionine beta-synthase
Cystathionine beta-synthase (EC 4.2.1.22) (Beta-thionase) (Serine sulfhydrase)
Cystathionine B synthase
Synonyms
DescriptionFUNCTION: Hydro-lyase catalyzing the first step of the transsulfuration pathway, where the hydroxyl group of L-serine is displaced by L-homocysteine in a beta-replacement reaction to form L-cystathionine, the precursor of L-cysteine. This catabolic route allows the elimination of L-methionine and the toxic metabolite L-homocysteine . Also involved in the production of hydrogen sulfide, a gasotransmitter with signaling and cytoprotective effects on neurons (By similarity). .

AccessionsENST00000451248.5
ENST00000430013.1
Q5CCK6
C9JMA6
ENST00000441030.5
ENST00000352178.9 [P35520-1]
H7C2W0
ENST00000458223.5
Q5CCK7
H7C2H4
ENST00000398158.5 [P35520-1]
H7C1W6
ENST00000398165.8 [P35520-1]
P35520
ENST00000359624.7 [P35520-1]