SOCS2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SOCS2 at tissue level.

III. Associated gene sets

GO_0009966Biological processregulation of signal transduction
GO_0032355Biological processresponse to estradiol
GO_0016567Biological processprotein ubiquitination
GO_0001558Biological processregulation of cell growth
GO_0046426Biological processnegative regulation of receptor signaling pathway via JAK-STAT
GO_0060396Biological processgrowth hormone receptor signaling pathway
GO_0032870Biological processcellular response to hormone stimulus
GO_0046854Biological processphosphatidylinositol phosphate biosynthetic process
GO_0060749Biological processmammary gland alveolus development
GO_0040015Biological processnegative regulation of multicellular organism growth
GO_0035556Biological processintracellular signal transduction
GO_0043066Biological processnegative regulation of apoptotic process
GO_0007595Biological processlactation
GO_0045666Biological processpositive regulation of neuron differentiation
GO_0007259Biological processcell surface receptor signaling pathway via JAK-STAT
GO_0005942Cellular componentphosphatidylinositol 3-kinase complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005159Molecular functioninsulin-like growth factor receptor binding
GO_0046935Molecular function1-phosphatidylinositol-3-kinase regulator activity
GO_0005131Molecular functiongrowth hormone receptor binding
GO_0008269Molecular functionJAK pathway signal transduction adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSOCS2
Protein nameSuppressor of cytokine signaling 2 (SOCS-2) (Cytokine-inducible SH2 protein 2) (CIS-2) (STAT-induced STAT inhibitor 2) (SSI-2)
Suppressor of cytokine signaling 2
SynonymsSSI2
STATI2
CIS2
DescriptionFUNCTION: SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway. Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.

AccessionsB5BU82
ENST00000551883.1
ENST00000622746.4
ENST00000548091.5
ENST00000548537.1
ENST00000549206.5
S4R3W1
ENST00000536696.6
ENST00000549887.1
ENST00000549122.5
F8VU91
S4R3Z4
ENST00000549510.1
O14508
ENST00000551556.2
F8VRV3
ENST00000340600.6
F8VS53