Name | Number of supported studies | Average coverage | |
---|---|---|---|
progenitor cell of mammary luminal epithelium | 3 studies | 41% ± 26% |
Insufficient scRNA-seq data for expression of LTF at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
breast | 87% | 22971.49 | 400 / 459 | 66% | 879.92 | 736 / 1118 |
pancreas | 97% | 1347.61 | 319 / 328 | 46% | 75.73 | 81 / 178 |
lung | 91% | 3404.53 | 528 / 578 | 50% | 118.09 | 583 / 1155 |
prostate | 73% | 11118.33 | 179 / 245 | 68% | 716.97 | 341 / 502 |
kidney | 89% | 12399.10 | 79 / 89 | 22% | 137.92 | 197 / 901 |
thymus | 98% | 1421.20 | 641 / 653 | 7% | 10.62 | 43 / 605 |
spleen | 100% | 8537.41 | 241 / 241 | 0% | 0 | 0 / 0 |
stomach | 76% | 16662.62 | 274 / 359 | 17% | 33.17 | 50 / 286 |
peripheral blood | 81% | 45648.39 | 751 / 929 | 0% | 0 | 0 / 0 |
adipose | 51% | 507.79 | 612 / 1204 | 0% | 0 | 0 / 0 |
esophagus | 20% | 1122.76 | 295 / 1445 | 20% | 30.22 | 36 / 183 |
brain | 10% | 101.48 | 277 / 2642 | 24% | 181.93 | 168 / 705 |
skin | 26% | 514.45 | 476 / 1809 | 3% | 6.11 | 13 / 472 |
heart | 28% | 181.80 | 240 / 861 | 0% | 0 | 0 / 0 |
uterus | 8% | 425.76 | 14 / 170 | 17% | 173.48 | 80 / 459 |
tonsil | 0% | 0 | 0 / 0 | 24% | 31.66 | 11 / 45 |
intestine | 12% | 222.90 | 112 / 966 | 8% | 13.36 | 44 / 527 |
liver | 13% | 127.07 | 30 / 226 | 3% | 2.64 | 11 / 406 |
ovary | 3% | 12.93 | 5 / 180 | 11% | 34.52 | 47 / 430 |
bladder | 0% | 0 | 0 / 21 | 10% | 39.18 | 51 / 504 |
adrenal gland | 6% | 45.84 | 15 / 258 | 0% | 0.16 | 1 / 230 |
blood vessel | 6% | 46.57 | 77 / 1335 | 0% | 0 | 0 / 0 |
muscle | 4% | 41.80 | 33 / 803 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 1% | 1.12 | 1 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
GO_0032680 | Biological process | regulation of tumor necrosis factor production |
GO_0044793 | Biological process | negative regulation by host of viral process |
GO_0045071 | Biological process | negative regulation of viral genome replication |
GO_0060349 | Biological process | bone morphogenesis |
GO_2000308 | Biological process | negative regulation of tumor necrosis factor (ligand) superfamily member 11 production |
GO_1900159 | Biological process | positive regulation of bone mineralization involved in bone maturation |
GO_0033690 | Biological process | positive regulation of osteoblast proliferation |
GO_2000117 | Biological process | negative regulation of cysteine-type endopeptidase activity |
GO_0019731 | Biological process | antibacterial humoral response |
GO_0050829 | Biological process | defense response to Gram-negative bacterium |
GO_2001205 | Biological process | negative regulation of osteoclast development |
GO_0006826 | Biological process | iron ion transport |
GO_0032780 | Biological process | negative regulation of ATP-dependent activity |
GO_0045669 | Biological process | positive regulation of osteoblast differentiation |
GO_0006959 | Biological process | humoral immune response |
GO_0051092 | Biological process | positive regulation of NF-kappaB transcription factor activity |
GO_0031640 | Biological process | killing of cells of another organism |
GO_0034145 | Biological process | positive regulation of toll-like receptor 4 signaling pathway |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0043123 | Biological process | positive regulation of canonical NF-kappaB signal transduction |
GO_0048525 | Biological process | negative regulation of viral process |
GO_1902732 | Biological process | positive regulation of chondrocyte proliferation |
GO_0006508 | Biological process | proteolysis |
GO_0001817 | Biological process | regulation of cytokine production |
GO_0031665 | Biological process | negative regulation of lipopolysaccharide-mediated signaling pathway |
GO_1900229 | Biological process | negative regulation of single-species biofilm formation in or on host organism |
GO_0061844 | Biological process | antimicrobial humoral immune response mediated by antimicrobial peptide |
GO_0002227 | Biological process | innate immune response in mucosa |
GO_0001503 | Biological process | ossification |
GO_0071902 | Biological process | positive regulation of protein serine/threonine kinase activity |
GO_0019732 | Biological process | antifungal humoral response |
GO_0005615 | Cellular component | extracellular space |
GO_0005576 | Cellular component | extracellular region |
GO_0005886 | Cellular component | plasma membrane |
GO_0035580 | Cellular component | specific granule lumen |
GO_0055037 | Cellular component | recycling endosome |
GO_0005769 | Cellular component | early endosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0032991 | Cellular component | protein-containing complex |
GO_0042581 | Cellular component | specific granule |
GO_0009986 | Cellular component | cell surface |
GO_0097013 | Cellular component | phagocytic vesicle lumen |
GO_1904724 | Cellular component | tertiary granule lumen |
GO_0005737 | Cellular component | cytoplasm |
GO_0030141 | Cellular component | secretory granule |
GO_0005634 | Cellular component | nucleus |
GO_0003677 | Molecular function | DNA binding |
GO_0004869 | Molecular function | cysteine-type endopeptidase inhibitor activity |
GO_0008201 | Molecular function | heparin binding |
GO_0140912 | Molecular function | membrane destabilizing activity |
GO_0043539 | Molecular function | protein serine/threonine kinase activator activity |
GO_0005506 | Molecular function | iron ion binding |
GO_0001530 | Molecular function | lipopolysaccharide binding |
GO_0005515 | Molecular function | protein binding |
GO_0004252 | Molecular function | serine-type endopeptidase activity |
Gene name | LTF |
Protein name | Lactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C] Lactotransferrin |
Synonyms | GIG12 LF |
Description | FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .; FUNCTION: [Lactotransferrin]: Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions . Has antimicrobial activity, which depends on the extracellular cation concentration . Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane . Can also prevent bacterial biofilm development in P.aeruginosa infection . Has weak antifungal activity against C.albicans . Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth . Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection . Can inhibit papillomavirus infections . Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling . Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells . Stimulates VEGFA-mediated endothelial cell migration and proliferation . Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs) . Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA . .; FUNCTION: Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection . N-terminal region shows strong antifungal activity against C.albicans . Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. .; FUNCTION: [Kaliocin-1]: Has antimicrobial activity and is able to permeabilize different ions through liposomal membranes. .; FUNCTION: [Lactoferroxin-A]: Has opioid antagonist activity . Shows preference for mu-receptor . .; FUNCTION: [Lactoferroxin-B]: Has opioid antagonist activity . Shows higher degrees of preference for kappa-receptors than for mu-receptors . .; FUNCTION: [Lactoferroxin-C]: Has opioid antagonist activity . Shows higher degrees of preference for kappa-receptors than for mu-receptors . .; FUNCTION: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions . This function contributes to the antimicrobial activity . Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites . .; FUNCTION: [Isoform DeltaLf]: Transcription factor with antiproliferative properties and ability to induce cell cycle arrest . Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters . . FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. . FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. . FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. . FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. . |
Accessions | ENST00000443496.5 ENST00000417439.5 A0A161I202 ENST00000431944.1 E7EQB2 ENST00000231751.9 [P02788-1] ENST00000426532.6 [P02788-2] E7ER44 C9JCF5 B2MV14 A0A804HKN5 P02788 ENST00000498301.1 |