LTF report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of LTF at tissue level.

III. Associated gene sets

GO_0032680Biological processregulation of tumor necrosis factor production
GO_0044793Biological processnegative regulation by host of viral process
GO_0045071Biological processnegative regulation of viral genome replication
GO_0060349Biological processbone morphogenesis
GO_2000308Biological processnegative regulation of tumor necrosis factor (ligand) superfamily member 11 production
GO_1900159Biological processpositive regulation of bone mineralization involved in bone maturation
GO_0033690Biological processpositive regulation of osteoblast proliferation
GO_2000117Biological processnegative regulation of cysteine-type endopeptidase activity
GO_0019731Biological processantibacterial humoral response
GO_0050829Biological processdefense response to Gram-negative bacterium
GO_2001205Biological processnegative regulation of osteoclast development
GO_0006826Biological processiron ion transport
GO_0032780Biological processnegative regulation of ATP-dependent activity
GO_0045669Biological processpositive regulation of osteoblast differentiation
GO_0006959Biological processhumoral immune response
GO_0051092Biological processpositive regulation of NF-kappaB transcription factor activity
GO_0031640Biological processkilling of cells of another organism
GO_0034145Biological processpositive regulation of toll-like receptor 4 signaling pathway
GO_0043066Biological processnegative regulation of apoptotic process
GO_0043123Biological processpositive regulation of canonical NF-kappaB signal transduction
GO_0048525Biological processnegative regulation of viral process
GO_1902732Biological processpositive regulation of chondrocyte proliferation
GO_0006508Biological processproteolysis
GO_0001817Biological processregulation of cytokine production
GO_0031665Biological processnegative regulation of lipopolysaccharide-mediated signaling pathway
GO_1900229Biological processnegative regulation of single-species biofilm formation in or on host organism
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0002227Biological processinnate immune response in mucosa
GO_0001503Biological processossification
GO_0071902Biological processpositive regulation of protein serine/threonine kinase activity
GO_0019732Biological processantifungal humoral response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005886Cellular componentplasma membrane
GO_0035580Cellular componentspecific granule lumen
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0070062Cellular componentextracellular exosome
GO_0032991Cellular componentprotein-containing complex
GO_0042581Cellular componentspecific granule
GO_0009986Cellular componentcell surface
GO_0097013Cellular componentphagocytic vesicle lumen
GO_1904724Cellular componenttertiary granule lumen
GO_0005737Cellular componentcytoplasm
GO_0030141Cellular componentsecretory granule
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0004869Molecular functioncysteine-type endopeptidase inhibitor activity
GO_0008201Molecular functionheparin binding
GO_0140912Molecular functionmembrane destabilizing activity
GO_0043539Molecular functionprotein serine/threonine kinase activator activity
GO_0005506Molecular functioniron ion binding
GO_0001530Molecular functionlipopolysaccharide binding
GO_0005515Molecular functionprotein binding
GO_0004252Molecular functionserine-type endopeptidase activity

IV. Literature review

[source]
Gene nameLTF
Protein nameLactotransferrin (Lactoferrin) (EC 3.4.21.-) (Growth-inhibiting protein 12) (Talalactoferrin) [Cleaved into: Lactoferricin-H (Lfcin-H); Kaliocin-1; Lactoferroxin-A; Lactoferroxin-B; Lactoferroxin-C]
Lactotransferrin
SynonymsGIG12
LF
DescriptionFUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .; FUNCTION: [Lactotransferrin]: Major iron-binding and multifunctional protein found in exocrine fluids such as breast milk and mucosal secretions . Has antimicrobial activity, which depends on the extracellular cation concentration . Antimicrobial properties include bacteriostasis, which is related to its ability to sequester free iron and thus inhibit microbial growth, as well as direct bactericidal properties leading to the release of lipopolysaccharides from the bacterial outer membrane . Can also prevent bacterial biofilm development in P.aeruginosa infection . Has weak antifungal activity against C.albicans . Has anabolic, differentiating and anti-apoptotic effects on osteoblasts and can also inhibit osteoclastogenesis, possibly playing a role in the regulation of bone growth . Promotes binding of species C adenoviruses to epithelial cells, promoting adenovirus infection . Can inhibit papillomavirus infections . Stimulates the TLR4 signaling pathway leading to NF-kappa-B activation and subsequent pro-inflammatory cytokine production while also interfering with the lipopolysaccharide (LPS)-stimulated TLR4 signaling . Inhibits neutrophil granulocyte migration to sites of apoptosis, when secreted by apoptotic cells . Stimulates VEGFA-mediated endothelial cell migration and proliferation . Binds heparin, chondroitin sulfate and possibly other glycosaminoglycans (GAGs) . Also binds specifically to pneumococcal surface protein A (PspA), the lipid A portion of bacterial lipopolysaccharide (LPS), lysozyme and DNA . .; FUNCTION: Lactoferricin binds to the bacterial surface and is crucial for the bactericidal functions. Has some antiviral activity against papillomavirus infection . N-terminal region shows strong antifungal activity against C.albicans . Contains two BBXB heparin-binding consensus sequences that appear to form the predominate functional GAG-binding site. .; FUNCTION: [Kaliocin-1]: Has antimicrobial activity and is able to permeabilize different ions through liposomal membranes. .; FUNCTION: [Lactoferroxin-A]: Has opioid antagonist activity . Shows preference for mu-receptor . .; FUNCTION: [Lactoferroxin-B]: Has opioid antagonist activity . Shows higher degrees of preference for kappa-receptors than for mu-receptors . .; FUNCTION: [Lactoferroxin-C]: Has opioid antagonist activity . Shows higher degrees of preference for kappa-receptors than for mu-receptors . .; FUNCTION: The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions . This function contributes to the antimicrobial activity . Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites . .; FUNCTION: [Isoform DeltaLf]: Transcription factor with antiproliferative properties and ability to induce cell cycle arrest . Binds to the DeltaLf response element found in the SKP1, BAX, DCPS, and SELENOH promoters . .

FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .

FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .

FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .

FUNCTION: Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. .

AccessionsENST00000443496.5
ENST00000417439.5
A0A161I202
ENST00000431944.1
E7EQB2
ENST00000231751.9 [P02788-1]
ENST00000426532.6 [P02788-2]
E7ER44
C9JCF5
B2MV14
A0A804HKN5
P02788
ENST00000498301.1