SUPV3L1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0032508Biological processDNA duplex unwinding
GO_0000965Biological processmitochondrial RNA 3'-end processing
GO_0030307Biological processpositive regulation of cell growth
GO_2000827Biological processmitochondrial RNA surveillance
GO_0006401Biological processRNA catabolic process
GO_0000962Biological processpositive regulation of mitochondrial RNA catabolic process
GO_0007005Biological processmitochondrion organization
GO_0043066Biological processnegative regulation of apoptotic process
GO_0000958Biological processmitochondrial mRNA catabolic process
GO_0035946Biological processmitochondrial mRNA surveillance
GO_0000957Biological processmitochondrial RNA catabolic process
GO_0035945Biological processmitochondrial ncRNA surveillance
GO_0006310Biological processDNA recombination
GO_0045025Cellular componentmitochondrial degradosome
GO_0042645Cellular componentmitochondrial nucleoid
GO_0005739Cellular componentmitochondrion
GO_0005759Cellular componentmitochondrial matrix
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0004386Molecular functionhelicase activity
GO_0003724Molecular functionRNA helicase activity
GO_0034458Molecular function3'-5' RNA helicase activity
GO_0042802Molecular functionidentical protein binding
GO_0003678Molecular functionDNA helicase activity
GO_0005524Molecular functionATP binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity
GO_0003725Molecular functiondouble-stranded RNA binding

IV. Literature review

[source]
Gene nameSUPV3L1
Protein nameSuv3 like RNA helicase
ATP-dependent RNA helicase SUPV3L1, mitochondrial (EC 3.6.4.13) (Suppressor of var1 3-like protein 1) (SUV3-like protein 1)
SynonymsSUV3
DescriptionFUNCTION: Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules . ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA. .

AccessionsB1AR60
Q8IYB8
ENST00000422378.1
ENST00000359655.9