POU3F3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071918Biological processurea transmembrane transport
GO_0021869Biological processforebrain ventricular zone progenitor cell division
GO_0072233Biological processmetanephric thick ascending limb development
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0010628Biological processpositive regulation of gene expression
GO_0072227Biological processmetanephric macula densa development
GO_0072218Biological processmetanephric ascending thin limb development
GO_0043066Biological processnegative regulation of apoptotic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0072236Biological processmetanephric loop of Henle development
GO_0007417Biological processcentral nervous system development
GO_0072240Biological processmetanephric DCT cell differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0048878Biological processchemical homeostasis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0021799Biological processcerebral cortex radially oriented cell migration
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0005654Cellular componentnucleoplasm
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0042803Molecular functionprotein homodimerization activity
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0043565Molecular functionsequence-specific DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0071837Molecular functionHMG box domain binding

IV. Literature review

[source]
Gene namePOU3F3
Protein namePOU domain, class 3, transcription factor 3 (Brain-specific homeobox/POU domain protein 1) (Brain-1) (Brn-1) (Octamer-binding protein 8) (Oct-8) (Octamer-binding transcription factor 8) (OTF-8)
SynonymsOTF8
BRN1
DescriptionFUNCTION: Transcription factor that acts synergistically with SOX11 and SOX4. Plays a role in neuronal development . Is implicated in an enhancer activity at the embryonic met-mesencephalic junction; the enhancer element contains the octamer motif (5'-ATTTGCAT-3') (By similarity). .

AccessionsENST00000361360.4
ENST00000674056.1
P20264