Name | Number of supported studies | Average coverage | |
---|---|---|---|
endothelial cell | 20 studies | 30% ± 13% | |
fibroblast | 18 studies | 29% ± 13% | |
pericyte | 13 studies | 32% ± 15% | |
smooth muscle cell | 13 studies | 29% ± 12% | |
basal cell | 11 studies | 32% ± 16% | |
connective tissue cell | 11 studies | 43% ± 19% | |
plasmacytoid dendritic cell | 10 studies | 25% ± 8% | |
conventional dendritic cell | 9 studies | 27% ± 11% | |
macrophage | 9 studies | 24% ± 6% | |
epithelial cell | 9 studies | 49% ± 19% | |
ciliated cell | 9 studies | 34% ± 13% | |
B cell | 8 studies | 24% ± 10% | |
myofibroblast cell | 8 studies | 41% ± 15% | |
natural killer cell | 8 studies | 25% ± 7% | |
neuron | 8 studies | 51% ± 27% | |
endothelial cell of lymphatic vessel | 8 studies | 25% ± 9% | |
abnormal cell | 7 studies | 31% ± 9% | |
CD8-positive, alpha-beta T cell | 7 studies | 26% ± 6% | |
secretory cell | 6 studies | 23% ± 13% | |
progenitor cell | 6 studies | 45% ± 16% | |
goblet cell | 6 studies | 25% ± 10% | |
interneuron | 6 studies | 36% ± 13% | |
CD4-positive, alpha-beta T cell | 6 studies | 27% ± 10% | |
oligodendrocyte precursor cell | 6 studies | 34% ± 12% | |
hematopoietic precursor cell | 5 studies | 39% ± 16% | |
monocyte | 5 studies | 18% ± 1% | |
endothelial cell of artery | 5 studies | 20% ± 6% | |
enteroendocrine cell | 5 studies | 39% ± 17% | |
mesothelial cell | 5 studies | 48% ± 18% | |
vein endothelial cell | 5 studies | 29% ± 11% | |
hematopoietic stem cell | 5 studies | 28% ± 11% | |
pro-B cell | 5 studies | 38% ± 9% | |
club cell | 5 studies | 26% ± 6% | |
precursor B cell | 5 studies | 32% ± 12% | |
endothelial cell of vascular tree | 5 studies | 18% ± 3% | |
GABAergic neuron | 5 studies | 38% ± 8% | |
glutamatergic neuron | 5 studies | 50% ± 7% | |
naive B cell | 5 studies | 18% ± 3% | |
transit amplifying cell | 5 studies | 22% ± 6% | |
oligodendrocyte | 5 studies | 30% ± 4% | |
precursor cell | 4 studies | 41% ± 25% | |
classical monocyte | 4 studies | 21% ± 5% | |
T cell | 4 studies | 38% ± 21% | |
intestinal crypt stem cell | 4 studies | 25% ± 3% | |
leukocyte | 4 studies | 21% ± 5% | |
erythroblast | 4 studies | 45% ± 23% | |
brush cell | 4 studies | 33% ± 20% | |
CD16-negative, CD56-bright natural killer cell, human | 4 studies | 18% ± 2% | |
dendritic cell | 4 studies | 35% ± 17% | |
type I pneumocyte | 4 studies | 29% ± 8% | |
regulatory T cell | 4 studies | 23% ± 7% | |
erythrocyte | 4 studies | 38% ± 21% | |
astrocyte | 4 studies | 26% ± 6% | |
plasmablast | 3 studies | 49% ± 4% | |
non-classical monocyte | 3 studies | 24% ± 3% | |
neural crest cell | 3 studies | 59% ± 20% | |
glial cell | 3 studies | 38% ± 25% | |
microglial cell | 3 studies | 24% ± 1% | |
common myeloid progenitor | 3 studies | 30% ± 20% | |
lymphocyte | 3 studies | 23% ± 5% | |
myeloid cell | 3 studies | 26% ± 8% | |
capillary endothelial cell | 3 studies | 34% ± 11% | |
immature B cell | 3 studies | 23% ± 7% | |
retina horizontal cell | 3 studies | 27% ± 16% | |
pancreatic ductal cell | 3 studies | 44% ± 20% | |
megakaryocyte-erythroid progenitor cell | 3 studies | 55% ± 21% | |
mast cell | 3 studies | 22% ± 3% | |
CD8-positive, alpha-beta memory T cell | 3 studies | 22% ± 6% | |
memory B cell | 3 studies | 20% ± 4% | |
CD4-positive, alpha-beta memory T cell | 3 studies | 19% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 3804.69 | 1445 / 1445 | 100% | 25.45 | 183 / 183 |
stomach | 100% | 3235.89 | 359 / 359 | 100% | 25.44 | 286 / 286 |
intestine | 100% | 4136.23 | 966 / 966 | 100% | 27.62 | 526 / 527 |
uterus | 100% | 4751.69 | 170 / 170 | 100% | 33.96 | 458 / 459 |
lung | 100% | 3612.47 | 577 / 578 | 100% | 26.32 | 1154 / 1155 |
brain | 100% | 3116.80 | 2635 / 2642 | 100% | 20.20 | 705 / 705 |
breast | 100% | 3907.74 | 459 / 459 | 100% | 30.16 | 1115 / 1118 |
bladder | 100% | 4154.19 | 21 / 21 | 100% | 29.31 | 502 / 504 |
ovary | 100% | 4871.33 | 180 / 180 | 99% | 24.47 | 427 / 430 |
thymus | 100% | 3467.30 | 653 / 653 | 99% | 18.67 | 598 / 605 |
prostate | 100% | 3435.66 | 245 / 245 | 99% | 22.04 | 496 / 502 |
pancreas | 99% | 2262.40 | 326 / 328 | 99% | 17.90 | 176 / 178 |
skin | 100% | 4972.71 | 1809 / 1809 | 95% | 20.70 | 450 / 472 |
adrenal gland | 100% | 4053.74 | 258 / 258 | 94% | 16.88 | 217 / 230 |
kidney | 100% | 2800.39 | 89 / 89 | 92% | 13.00 | 827 / 901 |
liver | 97% | 1250.12 | 219 / 226 | 65% | 7.20 | 265 / 406 |
adipose | 100% | 3744.31 | 1204 / 1204 | 0% | 0 | 0 / 0 |
blood vessel | 100% | 4145.80 | 1335 / 1335 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 100% | 15.83 | 29 / 29 |
muscle | 100% | 2840.66 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3500.22 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 28.74 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 6.13 | 1 / 1 |
heart | 97% | 2373.44 | 838 / 861 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 86% | 11.26 | 69 / 80 |
peripheral blood | 83% | 2473.58 | 774 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_1902455 | Biological process | negative regulation of stem cell population maintenance |
GO_0060789 | Biological process | hair follicle placode formation |
GO_0071560 | Biological process | cellular response to transforming growth factor beta stimulus |
GO_0045347 | Biological process | negative regulation of MHC class II biosynthetic process |
GO_0061000 | Biological process | negative regulation of dendritic spine development |
GO_0042733 | Biological process | embryonic digit morphogenesis |
GO_1904645 | Biological process | response to amyloid-beta |
GO_0010944 | Biological process | negative regulation of transcription by competitive promoter binding |
GO_0032732 | Biological process | positive regulation of interleukin-1 production |
GO_2000757 | Biological process | negative regulation of peptidyl-lysine acetylation |
GO_0043066 | Biological process | negative regulation of apoptotic process |
GO_0035094 | Biological process | response to nicotine |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0031000 | Biological process | response to caffeine |
GO_0070301 | Biological process | cellular response to hydrogen peroxide |
GO_0042475 | Biological process | odontogenesis of dentin-containing tooth |
GO_0071300 | Biological process | cellular response to retinoic acid |
GO_1903351 | Biological process | cellular response to dopamine |
GO_0045862 | Biological process | positive regulation of proteolysis |
GO_2000273 | Biological process | positive regulation of signaling receptor activity |
GO_0003300 | Biological process | cardiac muscle hypertrophy |
GO_0009913 | Biological process | epidermal cell differentiation |
GO_0031507 | Biological process | heterochromatin formation |
GO_0042659 | Biological process | regulation of cell fate specification |
GO_0042220 | Biological process | response to cocaine |
GO_0032967 | Biological process | positive regulation of collagen biosynthetic process |
GO_0030336 | Biological process | negative regulation of cell migration |
GO_0061029 | Biological process | eyelid development in camera-type eye |
GO_0032760 | Biological process | positive regulation of tumor necrosis factor production |
GO_0042531 | Biological process | positive regulation of tyrosine phosphorylation of STAT protein |
GO_1902437 | Biological process | positive regulation of male mating behavior |
GO_0043433 | Biological process | negative regulation of DNA-binding transcription factor activity |
GO_0055093 | Biological process | response to hyperoxia |
GO_0010977 | Biological process | negative regulation of neuron projection development |
GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
GO_0048714 | Biological process | positive regulation of oligodendrocyte differentiation |
GO_0008284 | Biological process | positive regulation of cell population proliferation |
GO_0001975 | Biological process | response to amphetamine |
GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
GO_0045944 | Biological process | positive regulation of transcription by RNA polymerase II |
GO_0030512 | Biological process | negative regulation of transforming growth factor beta receptor signaling pathway |
GO_0034605 | Biological process | cellular response to heat |
GO_0048149 | Biological process | behavioral response to ethanol |
GO_2000736 | Biological process | regulation of stem cell differentiation |
GO_0061198 | Biological process | fungiform papilla formation |
GO_0000122 | Biological process | negative regulation of transcription by RNA polymerase II |
GO_0006338 | Biological process | chromatin remodeling |
GO_0032922 | Biological process | circadian regulation of gene expression |
GO_1902459 | Biological process | positive regulation of stem cell population maintenance |
GO_0036211 | Biological process | protein modification process |
GO_0010718 | Biological process | positive regulation of epithelial to mesenchymal transition |
GO_0016358 | Biological process | dendrite development |
GO_0032496 | Biological process | response to lipopolysaccharide |
GO_0035098 | Cellular component | ESC/E(Z) complex |
GO_0005634 | Cellular component | nucleus |
GO_0005654 | Cellular component | nucleoplasm |
GO_0032991 | Cellular component | protein-containing complex |
GO_0070822 | Cellular component | Sin3-type complex |
GO_0000118 | Cellular component | histone deacetylase complex |
GO_0005737 | Cellular component | cytoplasm |
GO_0000781 | Cellular component | chromosome, telomeric region |
GO_0000785 | Cellular component | chromatin |
GO_0016581 | Cellular component | NuRD complex |
GO_0031492 | Molecular function | nucleosomal DNA binding |
GO_1990841 | Molecular function | promoter-specific chromatin binding |
GO_0042393 | Molecular function | histone binding |
GO_0003682 | Molecular function | chromatin binding |
GO_0061629 | Molecular function | RNA polymerase II-specific DNA-binding transcription factor binding |
GO_0160010 | Molecular function | protein de-2-hydroxyisobutyrylase activity |
GO_0042826 | Molecular function | histone deacetylase binding |
GO_0019899 | Molecular function | enzyme binding |
GO_0004407 | Molecular function | histone deacetylase activity |
GO_0031072 | Molecular function | heat shock protein binding |
GO_0003723 | Molecular function | RNA binding |
GO_0005515 | Molecular function | protein binding |
GO_0033558 | Molecular function | protein lysine deacetylase activity |
GO_0160009 | Molecular function | histone decrotonylase activity |
GO_0051059 | Molecular function | NF-kappaB binding |
Gene name | HDAC2 |
Protein name | Histone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-) Histone deacetylase 2 |
Synonyms | |
Description | FUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR . Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity . May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A . In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively . . |
Accessions | ENST00000520895.5 E5RJ04 ENST00000425835.6 Q92769 E5RFP9 ENST00000524334.1 E5RK19 ENST00000523240.5 H3BM24 ENST00000523628.5 ENST00000518690.5 ENST00000519108.5 [Q92769-3] E5RGV4 B5MGH3 E5RFI6 ENST00000519065.6 [Q92769-1] E5RHE7 E5RH52 ENST00000368632.6 [Q92769-3] ENST00000521163.5 ENST00000522371.5 A0A7R6V290 ENST00000521610.5 E5RG37 |