HDAC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1902455Biological processnegative regulation of stem cell population maintenance
GO_0060789Biological processhair follicle placode formation
GO_0071560Biological processcellular response to transforming growth factor beta stimulus
GO_0045347Biological processnegative regulation of MHC class II biosynthetic process
GO_0061000Biological processnegative regulation of dendritic spine development
GO_0042733Biological processembryonic digit morphogenesis
GO_1904645Biological processresponse to amyloid-beta
GO_0010944Biological processnegative regulation of transcription by competitive promoter binding
GO_0032732Biological processpositive regulation of interleukin-1 production
GO_2000757Biological processnegative regulation of peptidyl-lysine acetylation
GO_0043066Biological processnegative regulation of apoptotic process
GO_0035094Biological processresponse to nicotine
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0031000Biological processresponse to caffeine
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0042475Biological processodontogenesis of dentin-containing tooth
GO_0071300Biological processcellular response to retinoic acid
GO_1903351Biological processcellular response to dopamine
GO_0045862Biological processpositive regulation of proteolysis
GO_2000273Biological processpositive regulation of signaling receptor activity
GO_0003300Biological processcardiac muscle hypertrophy
GO_0009913Biological processepidermal cell differentiation
GO_0031507Biological processheterochromatin formation
GO_0042659Biological processregulation of cell fate specification
GO_0042220Biological processresponse to cocaine
GO_0032967Biological processpositive regulation of collagen biosynthetic process
GO_0030336Biological processnegative regulation of cell migration
GO_0061029Biological processeyelid development in camera-type eye
GO_0032760Biological processpositive regulation of tumor necrosis factor production
GO_0042531Biological processpositive regulation of tyrosine phosphorylation of STAT protein
GO_1902437Biological processpositive regulation of male mating behavior
GO_0043433Biological processnegative regulation of DNA-binding transcription factor activity
GO_0055093Biological processresponse to hyperoxia
GO_0010977Biological processnegative regulation of neuron projection development
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0048714Biological processpositive regulation of oligodendrocyte differentiation
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0001975Biological processresponse to amphetamine
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0030512Biological processnegative regulation of transforming growth factor beta receptor signaling pathway
GO_0034605Biological processcellular response to heat
GO_0048149Biological processbehavioral response to ethanol
GO_2000736Biological processregulation of stem cell differentiation
GO_0061198Biological processfungiform papilla formation
GO_0000122Biological processnegative regulation of transcription by RNA polymerase II
GO_0006338Biological processchromatin remodeling
GO_0032922Biological processcircadian regulation of gene expression
GO_1902459Biological processpositive regulation of stem cell population maintenance
GO_0036211Biological processprotein modification process
GO_0010718Biological processpositive regulation of epithelial to mesenchymal transition
GO_0016358Biological processdendrite development
GO_0032496Biological processresponse to lipopolysaccharide
GO_0035098Cellular componentESC/E(Z) complex
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0032991Cellular componentprotein-containing complex
GO_0070822Cellular componentSin3-type complex
GO_0000118Cellular componenthistone deacetylase complex
GO_0005737Cellular componentcytoplasm
GO_0000781Cellular componentchromosome, telomeric region
GO_0000785Cellular componentchromatin
GO_0016581Cellular componentNuRD complex
GO_0031492Molecular functionnucleosomal DNA binding
GO_1990841Molecular functionpromoter-specific chromatin binding
GO_0042393Molecular functionhistone binding
GO_0003682Molecular functionchromatin binding
GO_0061629Molecular functionRNA polymerase II-specific DNA-binding transcription factor binding
GO_0160010Molecular functionprotein de-2-hydroxyisobutyrylase activity
GO_0042826Molecular functionhistone deacetylase binding
GO_0019899Molecular functionenzyme binding
GO_0004407Molecular functionhistone deacetylase activity
GO_0031072Molecular functionheat shock protein binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding
GO_0033558Molecular functionprotein lysine deacetylase activity
GO_0160009Molecular functionhistone decrotonylase activity
GO_0051059Molecular functionNF-kappaB binding

IV. Literature review

[source]
Gene nameHDAC2
Protein nameHistone deacetylase 2 (HD2) (EC 3.5.1.98) (Protein deacylase HDAC2) (EC 3.5.1.-)
Histone deacetylase 2
Synonyms
DescriptionFUNCTION: Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR . Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin . Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 . Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity . May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A . In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively . .

AccessionsENST00000520895.5
E5RJ04
ENST00000425835.6
Q92769
E5RFP9
ENST00000524334.1
E5RK19
ENST00000523240.5
H3BM24
ENST00000523628.5
ENST00000518690.5
ENST00000519108.5 [Q92769-3]
E5RGV4
B5MGH3
E5RFI6
ENST00000519065.6 [Q92769-1]
E5RHE7
E5RH52
ENST00000368632.6 [Q92769-3]
ENST00000521163.5
ENST00000522371.5
A0A7R6V290
ENST00000521610.5
E5RG37